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BMPR1A bone morphogenetic protein receptor type 1A [ Gallus gallus (chicken) ]

Gene ID: 396308, updated on 3-Dec-2024
Official Symbol
BMPR1Aprovided by CGNC
Official Full Name
bone morphogenetic protein receptor type 1Aprovided by CGNC
Primary source
CGNC:1421
See related
Ensembl:ENSGALG00010010465
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ALK-3; BRK-1; BMPR-1
Orthologs
human mouse all
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See BMPR1A in Genome Data Viewer
Location:
chromosome: 6
Exon count:
15
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (3204001..3283880)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (3075840..3155930)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene WAPL cohesin release factor Neighboring gene LIM domain binding 3 Neighboring gene uncharacterized LOC107053617 Neighboring gene multimerin 2 Neighboring gene synuclein gamma Neighboring gene adipogenesis regulatory factor

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The finding that retinal gene expression for BMP2, 4, 7 and their receptors are not affected by short-term optical defocus contrasts with previous observations of sign-dependent expression changes for the same genes in the RPE.
    Title: Differential gene expression of BMP2 and BMP receptors in chick retina & choroid induced by imposed optical defocus.
  2. This paper highlights that targeting the BMP and TGFbeta type I and type II receptors causes a downregulation of XIAP, TAK1, and Id1 leading to cell death of lung cancer cells.
    Title: Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death.
  3. BMP signaling via Bmpr1a and Bmpr1b, is sufficient to modify nuclear organization in the chick diencephalon
    Title: Altered BMP signaling disrupts chick diencephalic development.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta receptor activity, type I IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dorsal/ventral pattern formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
bone morphogenetic protein receptor type-1A
Names
BMP receptor 1
bone morphogenetic protein receptor, type IA
bone morphogenic protein receptor 1
protein kinase
NP_990688.2
XP_015143446.1
XP_015143447.1
XP_046775895.1
XP_046775896.1
XP_046775897.1
XP_046775898.1
XP_046798721.1
XP_046798722.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205357.2 → NP_990688.2  bone morphogenetic protein receptor type-1A precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000227
    UniProtKB/TrEMBL
    F1P3H0, Q90754
    Related
    ENSGALP00010014219.1, ENSGALT00010025016.1
    Conserved Domains (3) summary
    cd14220
    Location:239 → 525
    STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
    pfam01064
    Location:63 → 134
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:206 → 233
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3204001..3283880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015287960.4 → XP_015143446.1  bone morphogenetic protein receptor type-1A isoform X1

    UniProtKB/TrEMBL
    F1P3H0, Q90754
    Conserved Domains (3) summary
    cd14220
    Location:239 → 525
    STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
    pfam01064
    Location:63 → 134
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:206 → 233
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

  2. XM_015287961.4 → XP_015143447.1  bone morphogenetic protein receptor type-1A isoform X1

    UniProtKB/TrEMBL
    F1P3H0, Q90754
    Conserved Domains (3) summary
    cd14220
    Location:239 → 525
    STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
    pfam01064
    Location:63 → 134
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:206 → 233
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

  3. XM_046942765.1 → XP_046798721.1  bone morphogenetic protein receptor type-1A isoform X1

    UniProtKB/TrEMBL
    F1P3H0, Q90754

  4. XM_046942766.1 → XP_046798722.1  bone morphogenetic protein receptor type-1A isoform X1

    UniProtKB/TrEMBL
    F1P3H0, Q90754

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    3075840..3155930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919939.1 → XP_046775895.1  bone morphogenetic protein receptor type-1A isoform X1

    UniProtKB/TrEMBL
    F1P3H0, Q90754

  2. XM_046919941.1 → XP_046775897.1  bone morphogenetic protein receptor type-1A isoform X1

    UniProtKB/TrEMBL
    F1P3H0, Q90754

  3. XM_046919940.1 → XP_046775896.1  bone morphogenetic protein receptor type-1A isoform X1

    UniProtKB/TrEMBL
    F1P3H0, Q90754

  4. XM_046919942.1 → XP_046775898.1  bone morphogenetic protein receptor type-1A isoform X1

    UniProtKB/TrEMBL
    F1P3H0, Q90754
Nucleotide Protein Strain
Heading Accession and Version

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