HRAS HRas proto-oncogene, GTPase [Gallus gallus (chicken)] - Gene

Summary

Symbol: HRASprovided by CGNC
Full Name: HRas proto-oncogene, GTPaseprovided by CGNC
Primary source: CGNC:5197
See related: Ensembl:ENSGALG00010025590
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: H-RAS; HRAS1; p21ras; H-Ras-1; c-H-ras
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (15587152..15641067)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (15561453..15615386)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data describe the mechanisms of oncogenesis induced in chickens by the myeloblastosis-associated virus 2 retrovirus; analyses identified HRAS, EGFR, MET, and RON as insertionally mutagenized driver genes and characterized the mechanisms of their tumorigenic activation
Title: HRAS, EGFR, MET, and RON Genes Are Recurrently Activated by Provirus Insertion in Liver Tumors Induced by the Retrovirus Myeloblastosis-Associated Virus 2.
BLNK recruits active H-Ras to the BCR complex, which is essential for sustained surface expression of BCR in the form of the cap and for the signal leading to functional ERK activation
Title: BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation.

Submit: New GeneRIF Correction

General gene information

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Homology

Homologs of the HRAS gene: The HRAS gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 341 organisms have orthologs with human gene HRAS
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein-membrane adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in T-helper 1 type immune response	IEA Inferred from Electronic Annotation more info
involved_in adipose tissue development	IEA Inferred from Electronic Annotation more info
involved_in cellular response to gamma radiation	IEA Inferred from Electronic Annotation more info
involved_in defense response to protozoan	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in oncogene-induced cell senescence	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phospholipase C activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ruffle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of wound healing	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GTPase complex	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: GTPase HRas

Names: Harvey rat sarcoma viral oncogene homolog; transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; v-Ha-ras Harvey rat sarcoma viral oncogene-like protein

NP_001383675.1

EC 3.6.5.2

NP_001383676.1

EC 3.6.5.2

NP_001383677.1

EC 3.6.5.2

NP_990623.1

EC 3.6.5.2

XP_046773855.1

EC 3.6.5.2

XP_046773856.1

EC 3.6.5.2

XP_046773857.1

EC 3.6.5.2

XP_046773858.1

EC 3.6.5.2

XP_046773859.1

EC 3.6.5.2

XP_046797430.1

EC 3.6.5.2

XP_046797431.1

EC 3.6.5.2

XP_046797432.1

EC 3.6.5.2

XP_046797433.1

EC 3.6.5.2

XP_046797434.1

EC 3.6.5.2

XP_046797435.1

EC 3.6.5.2

XP_046797436.1

EC 3.6.5.2

XP_046797437.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396746.1 → NP_001383675.1 GTPase HRas

Status: VALIDATED

Source sequence(s)

JAENSK010000214

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1

Conserved Domains (1) summary

cd04138
Location:3 → 164

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
NM_001396747.1 → NP_001383676.1 GTPase HRas

Status: VALIDATED

Source sequence(s)

JAENSK010000214

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1

Conserved Domains (1) summary

cd04138
Location:3 → 164

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
NM_001396748.1 → NP_001383677.1 GTPase HRas

Status: VALIDATED

Source sequence(s)

JAENSK010000214

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1

Conserved Domains (1) summary

cd04138
Location:3 → 164

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
NM_205292.2 → NP_990623.1 GTPase HRas

See identical proteins and their annotated locations for NP_990623.1

Status: VALIDATED

Source sequence(s)

JAENSK010000214

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1

Conserved Domains (1) summary

cd04138
Location:3 → 164

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

15587152..15641067

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046941474.1 → XP_046797430.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1
XM_046941476.1 → XP_046797432.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1
XM_046941477.1 → XP_046797433.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1
XM_046941479.1 → XP_046797435.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1
XM_046941480.1 → XP_046797436.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1
XM_046941478.1 → XP_046797434.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1
XM_046941481.1 → XP_046797437.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1
XM_046941475.1 → XP_046797431.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1

Related

ENSGALP00010038607.1, ENSGALT00010062441.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

15561453..15615386

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046917901.1 → XP_046773857.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1
XM_046917899.1 → XP_046773855.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1
XM_046917900.1 → XP_046773856.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1
XM_046917902.1 → XP_046773858.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1
XM_046917903.1 → XP_046773859.1 GTPase HRas isoform X1

UniProtKB/Swiss-Prot

P08642

UniProtKB/TrEMBL

F5ANT1