TP53 tumor protein p53 [Gallus gallus (chicken)] - Gene

Summary

Symbol: TP53provided by CGNC
Full Name: tumor protein p53provided by CGNC
Primary source: CGNC:49696
See related: Ensembl:ENSGALG00010000434
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	Unplaced Scaffold	NW_024096016.1 (5925..24899)

NW_024096016.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NW_024096016 Unplaced Scaffold Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alcohol-mediated calcium signals dysregulate pro-survival Snai2/PUMA/Bcl2 networks to promote p53-mediated apoptosis in avian neural crest progenitors.
Title: Alcohol-mediated calcium signals dysregulate pro-survival Snai2/PUMA/Bcl2 networks to promote p53-mediated apoptosis in avian neural crest progenitors.
SESN1 regulate p53 by a feedback mechanism which is indispensable for myoblast proliferation and apoptosis.
Title: MiR-16-5p targets SESN1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation.
TrkC tumor suppressor activity requires Hey1 and p53.
Title: Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.
Protein p53 occurs at key stages of development: in the esophagus during the remodeling of esophageal glands, in the proventriculus during the differentiation of the epithelium of the mucosa and in the gizzard during the formation of tubular glands.
Title: Analysis of the expression of p53 during the morphogenesis of the gastroesophageal mucosa of Gallus gallus domesticus (Linnaeus, 1758).
p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes.
Title: p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes.
Nitric oxide-induced cell death operates through p53-independent pathways, including a mitochondrial apoptotic pathway in chick embryo cardiomyocytes.
Title: The role of p53 in nitric oxide-induced cardiomyocyte cell death.
Nine genes previously unknown to be involved in regulating p53 activity were identified. Ectopic expression of these basic helix-loop-helix transcription factors activated p53 and induced apoptosis.
Title: Identification of p53 regulators by genome-wide functional analysis.
Results suggest that extensive deletions are efficient mechanisms of TP53 inactivation, occurring as early events during the immortalization of v-src-transformed chicken cells.
Title: Deletions in the DNA-binding domain of the TP53 gene in v-src-transformed chicken cells.
results suggest that the short form of p53 could play a role in the initiation of apoptosis induced by the chemotherapeutic compound, and that the regulation of its expression may be important for the maintenance of transformation status.
Title: The presence of a short form of p53 in chicken lymphoblastoid cell lines during apoptosis.
An initial down-regulation of p53 allowed the SC-2 cells to bypass senescence. The inactivation of p53, and consequently p21WAF1, likely contributed to the SC-2 cells becoming a fully immortal cell line.
Title: Contributions of differential p53 expression in the spontaneous immortalization of a chicken embryo fibroblast cell line.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cellular tumor antigen p53

Names: tumor suppressor p53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205264.1 → NP_990595.1 cellular tumor antigen p53

See identical proteins and their annotated locations for NP_990595.1

Status: PROVISIONAL

Source sequence(s)

X13057

UniProtKB/Swiss-Prot

P10360

Related

ENSGALP00010000467.1, ENSGALT00010000901.1

Conserved Domains (2) summary

pfam07710
Location:300 → 335

P53_tetramer; P53 tetramerization motif

cl14608
Location:80 → 275

P53; P53 DNA-binding domain