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HSP90AB1 heat shock protein 90 alpha family class B member 1 [ Gallus gallus (chicken) ]

Gene ID: 396188, updated on 5-Sep-2025
Official Symbol
HSP90AB1provided by CGNC
Official Full Name
heat shock protein 90 alpha family class B member 1provided by CGNC
Primary source
CGNC:49691
See related
Ensembl:ENSGALG00010019591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
HSPCB; Hsp90beta
Orthologs
human mouse all
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See HSP90AB1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (29961033..29966993, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (29888517..29894478, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor epsilon Neighboring gene solute carrier family 35 member B2 Neighboring gene microRNA mir-12259 Neighboring gene solute carrier family 29 member 1 Neighboring gene spectrin beta chain, brain 4-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The association of SNPs in Hsp90β gene 5' flanking region with thermo tolerance traits and tissue mRNA expression in two chicken breeds. Chen ZY, et al. Mol Biol Rep, 2013 Sep. PMID 23793829
  2. Depletion of hsp90beta induces multiple defects in B cell receptor signaling. Shinozaki F, et al. J Biol Chem, 2006 Jun 16. PMID 16617057
  3. Cloning of chicken hsp90 beta: the only vertebrate hsp90 insensitive to heat shock. Meng X, et al. Biochem Biophys Res Commun, 1993 Jan 29. PMID 7916597
  4. Role of Hsp90 in CpG ODN mediated immunostimulation in avian macrophages. Bhat A, et al. Mol Immunol, 2010 Mar. PMID 20096933
  5. The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes. Johnson J, et al. J Steroid Biochem Mol Biol, 1996 Jan. PMID 8603045

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNP of C.-141G>A in the 5' flanking region of the Hsp90beta gene in chicken had some effect on thermo tolerance traits, which may be a potential molecular marker of thermo tolerance.
    Title: The association of SNPs in Hsp90β gene 5' flanking region with thermo tolerance traits and tissue mRNA expression in two chicken breeds.
  2. Hsp90alpha but not Hsp90beta binds with the CpG oligodeoxynucleotides (ODN 2007) and may play a major role in CpG ODN(2007) induced immunoactivation in avian macrophage cells.
    Title: Role of Hsp90 in CpG ODN mediated immunostimulation in avian macrophages.
  3. hsp90beta has a role in B cell receptor signaling
    Title: Depletion of hsp90beta induces multiple defects in B cell receptor signaling.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to heat IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
heat shock cognate protein HSP 90-beta
Names
heat shock 90kDa protein 1, beta
heat shock protein 90 beta
heat shock protein 90 kDa
heat shock protein 90kDa alpha (cytosolic), class B member 1
hsp90 beta
NP_001384246.1

Length

  • 724

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397317.1 → NP_001384246.1  heat shock cognate protein HSP 90-beta

    Status: VALIDATED

    Source sequence(s)
    BU131234, CD764346, CF251814, CO506474, DR417746, HAEK01047440, HAEK01125965, HAEK01190173, JAENSK010000063, X70101
    UniProtKB/Swiss-Prot
    Q04619
    Conserved Domains (1) summary
    PTZ00272
    Location:13 → 724
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    29961033..29966993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015283624.4 → XP_015139110.2  heat shock cognate protein HSP 90-beta isoform X1

    UniProtKB/Swiss-Prot
    Q04619
    Related
    ENSGALP00010028006.1, ENSGALT00010047254.1
    Conserved Domains (1) summary
    PTZ00272
    Location:13 → 724
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

RNA

  1. XR_005858071.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    29888517..29894478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046913209.1 → XP_046769165.1  heat shock cognate protein HSP 90-beta isoform X1

    UniProtKB/Swiss-Prot
    Q04619

RNA

  1. XR_006933912.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_206959.1: Suppressed sequence

    Description
    NM_206959.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04619.1 GenPept UniProtKB/Swiss-Prot:Q04619

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials