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BDNF brain derived neurotrophic factor [ Gallus gallus (chicken) ]

Gene ID: 396186, updated on 7-Dec-2024
Symbol
BDNFprovided by CGNC
Full Name
brain derived neurotrophic factorprovided by CGNC
Primary source
CGNC:9230
See related
Ensembl:ENSGALG00010020046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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See BDNF in Genome Data Viewer
Location:
chromosome: 5
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (3939046..3993002, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (3904558..3958514, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing G protein-coupled receptor 4 Neighboring gene lin-7 homolog C, crumbs cell polarity complex component Neighboring gene uncharacterized LOC101751437 Neighboring gene microRNA 1760

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Prenatal Sensory Stimulation Induces BDNF Gene Expression in the Brain and Potentiates the Development of Species-Specific Predisposition in Newborn Chicks. Tiunova AA, et al. Bull Exp Biol Med, 2018 Dec. PMID 30488213
  2. Spontaneous retinal activity modulates BDNF trafficking in the developing chick visual system. Chytrova G, et al. Mol Cell Neurosci, 2004 Apr. PMID 15080885
  3. Brain-derived neurotrophic factor response in vulnerable and resilient genetic lines in the chick anxiety-depression model. Loria MJ, et al. Behav Brain Res, 2013 May 15. PMID 23396147
  4. Brain-derived neurotrophic factor is critically involved in thermal-experience-dependent developmental plasticity. Katz A, et al. J Neurosci, 2006 Apr 12. PMID 16611805, Free PMC Article
  5. Motoneuron programmed cell death in response to proBDNF. Taylor AR, et al. Dev Neurobiol, 2012 May. PMID 21834083, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prenatal sensory stimulation induces BDNF gene expression in the brain and potentiates the development of natural pattern recognition in newborn chicks.
    Title: Prenatal Sensory Stimulation Induces BDNF Gene Expression in the Brain and Potentiates the Development of Species-Specific Predisposition in Newborn Chicks.
  2. BDNF released by preganglionic axons acts chemotactically on TrkB-positive sympathetic neurons, to pattern the developing peripheral nervous system.
    Title: TrkB/BDNF signalling patterns the sympathetic nervous system.
  3. The stress resilient Production Reds showed stable BDNF levels across the isolation test period whereas the vulnerable Black Australorps showed an increase in hippocampal BDNF levels
    Title: Brain-derived neurotrophic factor response in vulnerable and resilient genetic lines in the chick anxiety-depression model.
  4. Muscle cells produce and secrete proBDNF, which through its interaction with p75NTR and sortilin promotes a caspase-dependent death of motor neurons in culture.
    Title: Motoneuron programmed cell death in response to proBDNF.
  5. These results suggest that BDNF promotes the induction of imprinting through TrkB exclusively during the critical period.
    Title: Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks.
  6. Activation of BDNF/TrkB signaling in the intermediate medial hyperpallium apicale is not involved in memory acquisition in filial imprinting in newly hatched chicks.
    Title: Activation of brain-derived neurotrophic factor/tropomyosin-related kinase B signaling accompanying filial imprinting in domestic chicks (Gallus gallus domesticus).
  7. Levels of NGF, BDNF and NT-3 were all up regulated from E7 to E14 in the spinal cord of embryonic chicken during development.
    Title: [The expression level of NGF, BDNF and NT-3 in spinal cord of growing embryonic chicken].
  8. An increase in BDNF was observed in both auditory stimulated groups. The increased levels of BDNF may help in regulating synaptic plasticity.
    Title: Prenatal auditory stimulation alters the levels of CREB mRNA, p-CREB and BDNF expression in chick hippocampus.
  9. mRNA expression level of cBDNF1 may be related to the DNA methylation status with a potential role of variant cBDNF1 in Marek disease tumor resistance and susceptibility
    Title: Alternative splicing variants and DNA methylation status of BDNF in inbred chicken lines.
  10. Interactions between BDNF and the T(3) thyroid hormone and/or corticosterone may constitute a homeostatic mechanism that links hypothalamic energy regulation controlling body composition.
    Title: Effects of BDNF, T3, and corticosterone on expression of the hypothalamic obesity gene network in vivo and in vitro.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nerve growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nerve development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nerve growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of collateral sprouting IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
neurotrophic factor BDNF precursor form; brain-derived neurotrophic factor
Names
neurotrophic factor
pre-pro-brain-derived
proBDNF

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031616.2 → NP_001026787.1  neurotrophic factor BDNF precursor form isoform 2 precursor

    See identical proteins and their annotated locations for NP_001026787.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/Swiss-Prot
    P25429, Q45N27
    UniProtKB/TrEMBL
    K4MNE5, K4MQC6
    Related
    ENSGALP00010028563.1, ENSGALT00010048449.1
    Conserved Domains (1) summary
    smart00140
    Location:132 → 239
    NGF; Nerve growth factor (NGF or beta-NGF)

  2. NM_001398061.1 → NP_001384990.1  neurotrophic factor BDNF precursor form isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/TrEMBL
    K4MQC6
    Conserved Domains (1) summary
    smart00140
    Location:140 → 247
    NGF; Nerve growth factor (NGF or beta-NGF)

  3. NM_001398062.1 → NP_001384991.1  neurotrophic factor BDNF precursor form isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/TrEMBL
    K4MQC6
    Conserved Domains (1) summary
    smart00140
    Location:140 → 247
    NGF; Nerve growth factor (NGF or beta-NGF)

  4. NM_001398067.1 → NP_001384996.1  neurotrophic factor BDNF precursor form isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/Swiss-Prot
    P25429, Q45N27
    UniProtKB/TrEMBL
    K4MNE5, K4MQC6
    Related
    ENSGALP00010028574.1, ENSGALT00010048462.1
    Conserved Domains (1) summary
    smart00140
    Location:132 → 239
    NGF; Nerve growth factor (NGF or beta-NGF)

  5. NM_001398068.1 → NP_001384997.1  neurotrophic factor BDNF precursor form isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/Swiss-Prot
    P25429, Q45N27
    UniProtKB/TrEMBL
    K4MNE5, K4MQC6
    Related
    ENSGALP00010028556.1, ENSGALT00010048435.1
    Conserved Domains (1) summary
    smart00140
    Location:132 → 239
    NGF; Nerve growth factor (NGF or beta-NGF)

  6. NM_001398069.1 → NP_001384998.1  neurotrophic factor BDNF precursor form isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    UniProtKB/Swiss-Prot
    P25429, Q45N27
    UniProtKB/TrEMBL
    K4MNE5, K4MQC6
    Related
    ENSGALP00010028581.1, ENSGALT00010048472.1
    Conserved Domains (1) summary
    smart00140
    Location:132 → 239
    NGF; Nerve growth factor (NGF or beta-NGF)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3939046..3993002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015286153.4 → XP_015141639.1  brain-derived neurotrophic factor isoform X2

    UniProtKB/Swiss-Prot
    P25429, Q45N27
    UniProtKB/TrEMBL
    K4MNE5, K4MQC6
    Related
    ENSGALP00010028559.1, ENSGALT00010048443.1
    Conserved Domains (1) summary
    smart00140
    Location:132 → 239
    NGF; Nerve growth factor (NGF or beta-NGF)

  2. XM_015286148.4 → XP_015141634.1  brain-derived neurotrophic factor isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZCY1, K4MQC6
    Related
    ENSGALP00010028558.1, ENSGALT00010048440.1
    Conserved Domains (1) summary
    smart00140
    Location:149 → 256
    NGF; Nerve growth factor (NGF or beta-NGF)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    3904558..3958514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917897.1 → XP_046773853.1  brain-derived neurotrophic factor isoform X2

    UniProtKB/Swiss-Prot
    P25429, Q45N27
    UniProtKB/TrEMBL
    K4MNE5, K4MQC6

  2. XM_046917896.1 → XP_046773852.1  brain-derived neurotrophic factor isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZCY1, K4MQC6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25429.2 GenPept UniProtKB/Swiss-Prot:P25429

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