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DCX-EMAP Doublecortin-domain-containing echinoderm-microtubule-associated protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39617, updated on 18-Sep-2024

Summary

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Official Symbol
DCX-EMAPprovided by FlyBase
Official Full Name
Doublecortin-domain-containing echinoderm-microtubule-associated proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0259099
Locus tag
Dmel_CG42247
See related
AllianceGenome:FB:FBgn0259099
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-71Aa; CG13466; CG13467; CG42247; Dmel\CG42247; dmEMAP
Old locus tag
Dmel_CG13466; Dmel_CG13467
Summary
Enables microtubule binding activity. Involved in adult locomotory behavior; melanotic encapsulation of foreign target; and sensory perception of sound. Located in sensory dendrite. Is expressed in head segment; presumptive embryonic/larval system; sensory nervous system primordium; and ventral sensory complex primordium. Human ortholog(s) of this gene implicated in subcortical band heterotopia. Orthologous to several human genes including EML1 (EMAP like 1) and EML4 (EMAP like 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See DCX-EMAP in Genome Data Viewer
Location:
71A2-71A2; 3-42 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14903805..14942907)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14896905..14936007)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45398 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Brother of Bearded A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NOMPC, a member of the TRP channel family, localizes to the tubular body and distal cilium of Drosophila campaniform and chordotonal receptor cells. Liang X, et al. Cytoskeleton (Hoboken), 2011 Jan. PMID 21069788, Free PMC Article
  2. A doublecortin containing microtubule-associated protein is implicated in mechanotransduction in Drosophila sensory cilia. Bechstedt S, et al. Nat Commun, 2010 Apr 12. PMID 20975667, Free PMC Article
  3. Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila. Bardin AJ, et al. Dev Cell, 2006 Feb. PMID 16459303
  4. A Forward Genetic Approach to Mapping a P-Element Second Site Mutation Identifies DCP2 as a Novel Tumor Suppressor in Drosophila melanogaster. Mishra R, et al. G3 (Bethesda), 2020 Aug 5. PMID 32591349, Free PMC Article
  5. Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes. Lai EC, et al. Development, 2000 Jan. PMID 10603347

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DCX-EMAP is a core organizer for the ultrastructure of Drosophila mechanosensory organelles.
    Title: DCX-EMAP is a core organizer for the ultrastructure of Drosophila mechanosensory organelles.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule stabilizing activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in melanotic encapsulation of foreign target IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sensory dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sensory dendrite IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Doublecortin-domain-containing echinoderm-microtubule-associated protein
Names
CG42247-PC
CG42247-PD
CG42247-PF
CG42247-PG
DCX-EMAP-PC
DCX-EMAP-PD
DCX-EMAP-PF
DCX-EMAP-PG
Doublecortin-domain-containing echinoderm-microtubule-associated protein ortholog
doublecortin
doublecortin-domain-containing echinoderm-microtubule-associated protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14903805..14942907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274921.1 → NP_001261850.1  Doublecortin-domain-containing echinoderm-microtubule-associated protein, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261850.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF94
    Conserved Domains (6) summary
    smart00537
    Location:166 → 253
    DCX; Domain in the Doublecortin (DCX) gene product
    COG2319
    Location:500 → 965
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:446 → 514
    HELP; HELP motif
    sd00039
    Location:673 → 712
    7WD40; WD40 repeat [structural motif]
    cl00155
    Location:300 → 375
    UBQ; Ubiquitin-like proteins
    cl02567
    Location:521 → 911
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_140471.3 → NP_648728.2  Doublecortin-domain-containing echinoderm-microtubule-associated protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648728.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4IJ53, Q8IGY9, Q9NII4, Q9VUI2, Q9VUI3
    Conserved Domains (6) summary
    smart00537
    Location:166 → 253
    DCX; Domain in the Doublecortin (DCX) gene product
    COG2319
    Location:500 → 965
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:446 → 514
    HELP; HELP motif
    sd00039
    Location:673 → 712
    7WD40; WD40 repeat [structural motif]
    cl00155
    Location:300 → 375
    UBQ; Ubiquitin-like proteins
    cl02567
    Location:521 → 911
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_140472.2 → NP_648729.1  Doublecortin-domain-containing echinoderm-microtubule-associated protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648729.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VUI3
    Conserved Domains (4) summary
    COG2319
    Location:243 → 708
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:416 → 455
    7WD40; WD40 repeat [structural motif]
    cd17070
    Location:43 → 115
    DCX2_RP_like; Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein
    pfam03451
    Location:189 → 257
    HELP; HELP motif

  4. NM_001274922.1 → NP_001261851.1  Doublecortin-domain-containing echinoderm-microtubule-associated protein, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261851.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFN2
    Conserved Domains (4) summary
    COG2319
    Location:275 → 740
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:448 → 487
    7WD40; WD40 repeat [structural motif]
    cd17070
    Location:75 → 147
    DCX2_RP_like; Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein
    pfam03451
    Location:221 → 289
    HELP; HELP motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PF94 M9PF94
M9PFN2 M9PFN2
Q9VUI3.3 Q9VUI3

Gene LinkOut

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