INS insulin [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: INSprovided by CGNC
Official Full Name: insulinprovided by CGNC
Primary source: CGNC:4941
See related: Ensembl:ENSGALG00010024574
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (13352571..13357237)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (13321039..13325693)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that insulin signaling in skeletal muscle can be regulated by dietary factors (here, dietary content of omega-3 fatty acids).
Title: Modulation of the insulin anabolic signalling cascade in growing chickens by n-3 PUFA.
The present findings suggest the involvement of insulin in neuronal/glial coupling in the cerebellum.
Title: Insulin-dependent regulation of GLAST/EAAT1 in Bergmann glial cells.
Polymorphisms within the INS gene are associated with 55-week body weight.
Title: Polymorphisms in vitamin D receptor, osteopontin, insulin-like growth factor 1 and insulin, and their associations with bone, egg and growth traits in a layer--broiler cross in chickens.

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General gene information

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Markers

INSsts1 (e-PCR), detects polymorphism
- UniSTS:279906

INSsts2 (e-PCR), detects polymorphism
- UniSTS:279907

INSsts3 (e-PCR), detects polymorphism
- UniSTS:279908

UniSTS:267003 (e-PCR)
- UniSTS:267003

Ins1 (e-PCR), detects polymorphism
- UniSTS:267003

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin

Names: insulin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205222.3 → NP_990553.1 insulin preproinsulin precursor

See identical proteins and their annotated locations for NP_990553.1

Status: VALIDATED

Source sequence(s)

BX278627, JAENSK010000214, X58993

UniProtKB/Swiss-Prot

P01332, P67970, Q53YX4

UniProtKB/TrEMBL

A0A8V1A0I3

Related

ENSGALP00010036702.1, ENSGALT00010059942.1

Conserved Domains (1) summary

cd04367
Location:26 → 107

IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...