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MMP16 matrix metallopeptidase 16 [ Gallus gallus (chicken) ]

Gene ID: 396116, updated on 13-Apr-2026
Symbol
MMP16provided by CGNC
Full Name
matrix metallopeptidase 16provided by CGNC
Primary source
CGNC:49658
See related
Ensembl:ENSGALG00010012390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
MT3-MMP
Orthologs
all
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Try the new Transcripts and proteins table
See MMP16 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (123254491..123430269, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (123447538..123623560, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110000 Neighboring gene uncharacterized LOC121110002 Neighboring gene uncharacterized LOC121110001 Neighboring gene uncharacterized LOC121110007 Neighboring gene receptor interacting serine/threonine kinase 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A new role of the membrane-type matrix metalloproteinase 16 (MMP16/MT3-MMP) in neural crest cell migration. Roth L, et al. Int J Dev Biol, 2017. PMID 28621422
  2. Cloning and developmental expression of a membrane-type matrix metalloproteinase from chicken. Yang M, et al. J Biol Chem, 1996 Oct 11. PMID 8810327
  3. Collagen fibril growth during chicken tendon development: matrix metalloproteinase-2 and its activation. Jung JC, et al. Cell Tissue Res, 2009 Apr. PMID 19221802, Free PMC Article
  4. Roles of MMP/TIMP in regulating matrix swelling and cell migration during chick corneal development. Huh MI, et al. J Cell Biochem, 2007 Aug 1. PMID 17295208
  5. EST analysis of mRNAs expressed during embryogenesis in Gallus gallus. Jorge EC, et al. Int J Dev Biol, 2004 Jun. PMID 15300514

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MMP16 is a new effector participating in epithelial-to-mesenchymal-transition and in the migration of neural crest cells
    Title: A new role of the membrane-type matrix metalloproteinase 16 (MMP16/MT3-MMP) in neural crest cell migration.
  2. MMP-2/MT3-MMP are involved in the initiation and progression of fibril growth, matrix assembly, and tendon development.
    Title: Collagen fibril growth during chicken tendon development: matrix metalloproteinase-2 and its activation.
  3. These findings collectively show for the first time that multiple MMPs, ADAMs, and TIMPs appear to functionally interact during corneal development.
    Title: Roles of MMP/TIMP in regulating matrix swelling and cell migration during chick corneal development.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in skeletal system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
matrix metalloproteinase-16
Names
matrix metallopeptidase 16 (membrane-inserted)
matrix metalloproteinase 16 (membrane-inserted)
membrane type-matrix metalloproteinase
NP_990528.2
XP_025002826.1
XP_046766382.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205197.3 → NP_990528.2  matrix metalloproteinase-16

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000044
    UniProtKB/TrEMBL
    A0A1D5PZ77, A0A8V0YEB1
    Related
    ENSGALP00010017270.1, ENSGALT00010029680.1
    Conserved Domains (5) summary
    cd00094
    Location:342 → 534
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:126 → 291
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:126 → 291
    Peptidase_M10; Matrixin
    pfam01471
    Location:42 → 96
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:539 → 609
    DUF3377; Domain of unknown function (DUF3377)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    123254491..123430269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025147058.3 → XP_025002826.1  matrix metalloproteinase-16 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YEB1
    Conserved Domains (4) summary
    cd00094
    Location:342 → 493
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:126 → 291
    Peptidase_M10; Matrixin
    pfam01471
    Location:42 → 96
    PG_binding_1; Putative peptidoglycan binding domain
    cl26464
    Location:273 → 353
    Atrophin-1; Atrophin-1 family

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    123447538..123623560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910426.1 → XP_046766382.1  matrix metalloproteinase-16 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YEB1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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