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CRYAB crystallin alpha B [ Gallus gallus (chicken) ]

Gene ID: 396089, updated on 13-Apr-2026
Official Symbol
CRYABprovided by CGNC
Official Full Name
crystallin alpha Bprovided by CGNC
Primary source
CGNC:6010
See related
Ensembl:ENSGALG00010025192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
alpha(B)-crystallin
Orthologs
all
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See CRYAB in Genome Data Viewer
Location:
chromosome: 24
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 24 NC_052555.1 (6268918..6273113)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 24 NC_052596.1 (6229633..6233827)

Chromosome 24 - NC_052555.1Genomic Context describing neighboring genes Neighboring gene C11orf52 homolog Neighboring gene heat shock protein family B (small) member 2 Neighboring gene C11orf1 homolog Neighboring gene ferredoxin-fold anticodon binding domain containing 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Aspirin upregulates αB-Crystallin to protect the myocardium against heat stress in broiler chickens. Tang S, et al. Sci Rep, 2016 Nov 18. PMID 27857180, Free PMC Article
  2. Expression of αB-crystallin in the peripapillary glial cells of the developing chick retina. Kim JY, et al. Neurochem Res, 2011 Jan. PMID 20872245
  3. Changes in retinal alphaB-crystallin (cryab) RNA transcript levels during periods of altered ocular growth in chickens. Ashby RS, et al. Exp Eye Res, 2010 Feb. PMID 19878675
  4. Alternative transcriptional initiation and alternative use of polyadenylation signals in the alphaB-crystallin gene expressed in different chicken tissues. Macip S, et al. Gene, 1997 Mar 18. PMID 9099889
  5. Chicken heat shock protein HSPB1 increases and interacts with αB-crystallin in aged skeletal muscle. Ueda S, et al. Biosci Biotechnol Biochem, 2015. PMID 26139560

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELISAs indicated aspirin (ASA) induced CryAB in vivo to protect against heat stress-induced myocardial damage, but ASA did not induce CryAB in primary chicken myocardial cells.
    Title: Aspirin upregulates αB-Crystallin to protect the myocardium against heat stress in broiler chickens.
  2. These results suggest that HSPB1 protein forms complexes with alphaB-crystallin in aged chicken muscle and suppose to become the candidate of age-related bio-marker for verifying the age of chicken meat.
    Title: Chicken heat shock protein HSPB1 increases and interacts with αB-crystallin in aged skeletal muscle.
  3. Data demonstrate that peripapillary glial cells express alphaB-crystallin, which is not expressed in Muller cells, during retinal development.
    Title: Expression of αB-crystallin in the peripapillary glial cells of the developing chick retina.
  4. No significant changes in retinal cryab RNA transcript expression were seen in response to plus lenses compared to either contralateral control values
    Title: Changes in retinal alphaB-crystallin (cryab) RNA transcript levels during periods of altered ocular growth in chickens.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural constituent of eye lens IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein refolding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
alpha-crystallin B chain
Names
HspB5 protein
alpha B-crystallin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205176.2 → NP_990507.2  alpha-crystallin B chain

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000341
    UniProtKB/Swiss-Prot
    Q05713, Q90657
    UniProtKB/TrEMBL
    A0A3Q2TTM1
    Related
    ENSGALP00010037973.1, ENSGALT00010061460.1
    Conserved Domains (2) summary
    pfam00525
    Location:1 → 52
    Crystallin; Alpha crystallin A chain, N terminal
    cl00175
    Location:66 → 149
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    6268918..6273113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046903738.1 → XP_046759694.1  alpha-crystallin B chain isoform X1

    UniProtKB/TrEMBL
    A0A8V1A6F3

  2. XM_046903739.1 → XP_046759695.1  alpha-crystallin B chain isoform X1

    UniProtKB/TrEMBL
    A0A8V1A6F3
    Related
    ENSGALP00010037980.1, ENSGALT00010061482.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052596.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    6229633..6233827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046932302.1 → XP_046788258.1  alpha-crystallin B chain isoform X1

    UniProtKB/TrEMBL
    A0A8V1A6F3

  2. XM_046932303.1 → XP_046788259.1  alpha-crystallin B chain isoform X1

    UniProtKB/TrEMBL
    A0A8V1A6F3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05713.2 GenPept UniProtKB/Swiss-Prot:Q05713

Gene LinkOut

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