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NTRK3 neurotrophic receptor tyrosine kinase 3 [ Gallus gallus (chicken) ]

Gene ID: 396081, updated on 3-Dec-2024
Symbol
NTRK3provided by CGNC
Full Name
neurotrophic receptor tyrosine kinase 3provided by CGNC
Primary source
CGNC:49641
See related
Ensembl:ENSGALG00010020319
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TRKC
Orthologs
human mouse all
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See NTRK3 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
20
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (13239469..13433531)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (13117566..13311562)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S11 Neighboring gene mitochondrial ribosomal protein L46 Neighboring gene de-etiolated homolog 1 (Arabidopsis) Neighboring gene uncharacterized LOC107054207 Neighboring gene uncharacterized LOC107054206 Neighboring gene uncharacterized LOC112533196 Neighboring gene ATP/GTP binding protein like 1 Neighboring gene kelch like family member 25 Neighboring gene A-kinase anchoring protein 13

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Molecular cloning and expression of a novel truncated form of chicken trkC. Okazawa H, et al. FEBS Lett, 1993 Aug 23. PMID 8394830
  2. Molecular cloning and cellular localization of trkC in the chicken embryo. Williams R, et al. Brain Res Dev Brain Res, 1993 Oct 15. PMID 8261614
  3. Isoforms of the avian TrkC receptor: a novel kinase insertion dissociates transformation and process outgrowth from survival. Garner AS, et al. Neuron, 1994 Aug. PMID 8060621
  4. Neurotrophin-3 and TrkC are expressed in the outflow tract of the developing chicken heart. Bernd P, et al. Dev Dyn, 2004 Aug. PMID 15254910
  5. Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth. Ménard M, et al. PLoS Biol, 2018 May. PMID 29750782, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TrkC tumor suppressor activity requires Hey1 and p53.
    Title: Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.
  2. Neurotrophin-3 and TrkC are expressed in the outflow tract of the developing chicken heart
    Title: Neurotrophin-3 and TrkC are expressed in the outflow tract of the developing chicken heart.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neurotrophin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neurotrophin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
NT-3 growth factor receptor
Names
neurotrophic tyrosine kinase, receptor, type 3
trk-C
trkC tyrosine kinase
tyrosine kinase C receptor, TrkC receptor, high-affinity neurotrophin receptor
NP_990500.2
XP_015147467.2
XP_015147470.2
XP_046754868.1
XP_046780474.1
XP_046780475.1
XP_046780476.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205169.2 → NP_990500.2  NT-3 growth factor receptor precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000245
    UniProtKB/TrEMBL
    A0A8V0ZE65, A0A8V0ZK84
    Related
    ENSGALP00010029006.1, ENSGALT00010049057.1
    Conserved Domains (7) summary
    smart00082
    Location:160 → 189
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:218 → 301
    IG; Immunoglobulin
    COG4886
    Location:35 → 176
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd05094
    Location:534 → 845
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    cd00096
    Location:332 → 336
    Ig; Ig strand C [structural motif]
    cl11960
    Location:327 → 386
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    13239469..13433531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046898912.1 → XP_046754868.1  NT-3 growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZK84

  2. XM_015291981.4 → XP_015147467.2  NT-3 growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZCS3, A0A8V0ZK84
    Related
    ENSGALP00010029005.1, ENSGALT00010049056.1
    Conserved Domains (4) summary
    smart00082
    Location:160 → 189
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:218 → 301
    IG; Immunoglobulin
    cd05094
    Location:534 → 820
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]

  3. XM_015291984.4 → XP_015147470.2  NT-3 growth factor receptor isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZDR9
    Related
    ENSGALP00010028997.1, ENSGALT00010049048.1
    Conserved Domains (6) summary
    smart00082
    Location:160 → 189
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:218 → 301
    IG; Immunoglobulin
    COG4886
    Location:64 → 176
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    cd00096
    Location:332 → 337
    Ig; Ig strand C [structural motif]
    cl11960
    Location:327 → 386
    Ig; Immunoglobulin domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    13117566..13311562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046924518.1 → XP_046780474.1  NT-3 growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZK84

  2. XM_046924519.1 → XP_046780475.1  NT-3 growth factor receptor isoform X2

    UniProtKB/Swiss-Prot
    Q91011, Q91044, Q92022
    UniProtKB/TrEMBL
    A0A8V0ZK84

  3. XM_046924520.1 → XP_046780476.1  NT-3 growth factor receptor isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZDR9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91044.2 GenPept UniProtKB/Swiss-Prot:Q91044

Gene LinkOut

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