AGTR1 angiotensin II receptor type 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: AGTR1provided by CGNC
Full Name: angiotensin II receptor type 1provided by CGNC
Primary source: CGNC:49635
See related: Ensembl:ENSGALG00010017056
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	9	NC_052540.1 (12066216..12087850)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	9	NC_052581.1 (11869006..11890640)

Chromosome 9 - NC_052540.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In contrast to the authors' previous genome wide association study and microsatellite data, they find no association of the SNP genotypes or haplotypes in the region between 11.8 and 13.6 Mbp on chromosome 9, suggesting that the AGTR1 and UTS2D genes might have limited association with the disease phenotype.
Title: Further investigation of a quantitative trait locus for ascites on chromosome 9 in broiler chicken lines.
investigation of gene expression and role of Ang II receptor during embryonic development: expression in CAM and heart of embryo; limited effect of Ang II receptor antagonist on blood pressure of embryo
Title: Maturation of the angiotensin II cardiovascular response in the embryonic White Leghorn chicken (Gallus gallus).

Submit: New GeneRIF Correction

General gene information

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Homology

Orthologs from Annotation Pipeline: 396 organisms have orthologs with human gene AGTR1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables angiotensin type I receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables angiotensin type I receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables angiotensin type II receptor activity	IEA Inferred from Electronic Annotation more info
enables bradykinin receptor binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of CoA-transferase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage derived foam cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in viral entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: type-1 angiotensin II receptor

Names: AT1; AT1 receptor; angiotensin II type-1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205157.4 → NP_990488.1 type-1 angiotensin II receptor

See identical proteins and their annotated locations for NP_990488.1

Status: VALIDATED

Source sequence(s)

JAENSK010000240

UniProtKB/Swiss-Prot

P79785

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

12066216..12087850

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015291377.4 → XP_015146863.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785

Related

ENSGALP00010024104.1, ENSGALT00010041183.1

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_015291376.4 → XP_015146862.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785

Related

ENSGALP00010024113.1, ENSGALT00010041195.1

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_040705476.2 → XP_040561410.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_025153316.3 → XP_025009084.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_040705477.2 → XP_040561411.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_015291375.4 → XP_015146861.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785

Related

ENSGALP00010024111.1, ENSGALT00010041192.1

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_015291379.4 → XP_015146865.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_040705475.2 → XP_040561409.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785

Related

ENSGALP00010024110.1, ENSGALT00010041191.1

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

11869006..11890640

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046923617.1 → XP_046779573.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785
XM_046923614.1 → XP_046779570.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785
XM_046923618.1 → XP_046779574.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785
XM_046923616.1 → XP_046779572.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785
XM_046923621.1 → XP_046779577.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785
XM_046923615.1 → XP_046779571.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785
XM_046923619.1 → XP_046779575.1 type-1 angiotensin II receptor isoform X1

UniProtKB/Swiss-Prot

P79785