CD3E CD3e molecule [Gallus gallus (chicken)] - Gene

Summary

Symbol: CD3Eprovided by CGNC
Full Name: CD3e moleculeprovided by CGNC
Primary source: CGNC:5597
See related: Ensembl:ENSGALG00010023715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	24	NC_052555.1 (5503915..5511817)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	24	NC_052596.1 (5464206..5472104)

Chromosome 24 - NC_052555.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMR structure of the chicken CD3epsilondelta/gamma heterodimer revealed a unique dimer interface that results in a heterodimer with considerable deviation from the human and murine CD3epsilondelta and CD3epsilongamma; chicken CD3epsilondelta/gamma heterodimer also contains a unique molecular surface, with the majority of surface-exposed, nonconserved residues being clustered to a single face of the heterodimer.
Title: Structure of the chicken CD3εδ/γ heterodimer and its assembly with the αβT cell receptor.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive thymic T cell selection	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of alpha-beta T cell receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: T-cell surface glycoprotein CD3 epsilon chain

Names: CD3 epsilon; CD3E antigen, epsilon polypeptide; CD3e molecule, epsilon (CD3-TCR complex); TiT3 complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001397708.1 → NP_001384637.1 T-cell surface glycoprotein CD3 epsilon chain precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) has eight exons.

Source sequence(s)

AM068697, AM069228, BI391601, BU241154, CD736211, DT655806, JAENSK010000341

UniProtKB/TrEMBL

A0A8V0ZXL5, B3VMQ8

Conserved Domains (1) summary

smart00077
Location:153 → 173

ITAM; Immunoreceptor tyrosine-based activation motif
NM_001397711.1 → NP_001384640.1 T-cell surface glycoprotein CD3 epsilon chain precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) has nine exons.

Source sequence(s)

AM068697, AM069228, BI391601, BU241154, CD736211, CD761226, JAENSK010000341

UniProtKB/TrEMBL

A0A8V0ZXL5, B3VMQ8

Related

ENSGALP00010035081.1, ENSGALT00010057807.1

Conserved Domains (1) summary

smart00077
Location:153 → 173

ITAM; Immunoreceptor tyrosine-based activation motif
NM_206904.2 → NP_996787.2 T-cell surface glycoprotein CD3 epsilon chain precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) has six exons.

Source sequence(s)

AM068697, AM069228, BI391601, BU241154, CD736211

UniProtKB/TrEMBL

A0A8V0ZXL5, B3VMQ8

Conserved Domains (1) summary

smart00077
Location:153 → 173

ITAM; Immunoreceptor tyrosine-based activation motif