INFG interferon gamma [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: INFGprovided by CGNC
Official Full Name: interferon gammaprovided by CGNC
Primary source: CGNC:7521
See related: AnimalQTLdb:13440; Ensembl:ENSGALG00010011933
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: IFNG
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (35180845..35185013, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (35528373..35532541, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of IFN-gamma did not seem to fully abrogate vaccine-induced protection against Marek's disease in chickens.
Title: Effects of interferon-γ knockdown on vaccine-induced immunity against Marek's disease in chickens.
The effect of class B CpG ODN administered by subcutaneous or intraocular injection on cytokine expression in chickens is reported.
Title: The effects of subcutaneous and intraocular administration of class B ODN CpG in chicken on the expression of TLR21, IFN-γ and IL-1β.
Vitiligo in Smyth line chickens appears to be a Th1-polarized autoimmune disease, whereby IFN-gamma expression is strongly associated with parallel increases in IL-10 and IL-21, particularly during the early and active stages of vitiligo.
Title: IFN-γ, IL-21, and IL-10 co-expression in evolving autoimmune vitiligo lesions of Smyth line chickens.
zearalenone affects IL-2, IL-6, and IFN-gamma mRNA levels in the splenic lymphocytes of chickens
Title: Effects of zearalenone on IL-2, IL-6, and IFN-γ mRNA levels in the splenic lymphocytes of chickens.
Data show that IL-10, IFN-gamma and TNF-alpha contents in the cecal tonsil were significantly decreased in the 30, 45 and 60 mg/kg groups, while IL-6 content in the cecal tonsil was only decreased in 60 mg/kg at 14 and 28 days of age.
Title: Changes of IgA+ cells and cytokines in the cecal tonsil of broilers fed on diets supplemented with vanadium.
that in vitro stimulation with IBV resulted in ChIFN-gamma production in splenocytes of both infected birds and uninfected birds
Title: Infectious Bronchitis Virus induces acute interferon-gamma production through polyclonal stimulation of chicken leukocytes.
IFNG had lower diversity and coding sequence conservation, consistent with its function as an inflammatory cytokine; in contrast, the pleiotropic cytokine IL1B had higher diversity and showed signals of balancing selection moderated by recombination.
Title: Contrasting evolution of diversity at two disease-associated chicken genes.
The dose-response effects of supplemental dietary chormium on interferon-gamma expression in response to Newcastle disease virus vaccine in broiler chickens is reported.
Title: Effects of supplemental chromium on interferon-gamma (IFN-gamma) mRNA expression in response to Newcastle disease vaccine in broiler chicken.
The pivotal role of chicken interferon-gamma in the pathogenesis and immunosuppression of infectious bursal disease virus infection in in vivo, ex vivo and in vitro experiments are reported.
Title: Pivotal role of ChIFNgamma in the pathogenesis and immunosuppression of infectious bursal disease.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables type II interferon receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: interferon gamma

Names: IFN-gamma; Interferon-gamma level; interferon-gama

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205149.2 → NP_990480.1 interferon gamma precursor

See identical proteins and their annotated locations for NP_990480.1

Status: VALIDATED

Source sequence(s)

JAENSK010000012

UniProtKB/Swiss-Prot

D3GGX1, P49708, Q53YS2

UniProtKB/TrEMBL

C6KJC5, C8CLK2, Q06E05, Q1KMD4, Q66T03

Related

ENSGALP00010016393.1, ENSGALT00010028555.1

Conserved Domains (1) summary

pfam00714
Location:33 → 155

IFN-gamma; Interferon gamma

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

35180845..35185013 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

35528373..35532541 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)