RELA RELA proto-oncogene, NF-kB subunit [Gallus gallus (chicken)] - Gene

Summary

Symbol: RELAprovided by CGNC
Full Name: RELA proto-oncogene, NF-kB subunitprovided by CGNC
Primary source: CGNC:49615
See related: Ensembl:ENSGALG00000039409
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 33

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
104	current	GRCg6a (GCF_000002315.5)	33	NC_008465.4 (6490052..6498329, complement)
103	previous assembly	Gallus_gallus-5.0 (GCF_000002315.4)	Unplaced Scaffold	NT_464141.1 (65521..73783)
102	previous assembly	Gallus_gallus-4.0 (GCF_000002315.3)	Unplaced Scaffold	NW_003779054.1 (164..1087, complement)

Chromosome 33 - NC_008465.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Homology

Homologs of the RELA gene: The RELA gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 198 organisms have orthologs with human gene RELA
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	ISS Inferred from Sequence or Structural Similarity more info
DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
I-kappaB kinase/NF-kappaB signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
MyD88-dependent toll-like receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
NIK/NF-kappaB signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
cellular response to stress	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
innate immune response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of I-kappaB kinase/NF-kappaB signaling	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to cytokine	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
NF-kappaB complex	IEA Inferred from Electronic Annotation more info
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transcription factor p65

Names: NF-kB p65 subunit; nuclear factor NF-kappa-B p65 subunit; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel reticuloendotheliosis viral oncogene homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205129.1 → NP_990460.1 transcription factor p65

See identical proteins and their annotated locations for NP_990460.1

Status: PROVISIONAL

Source sequence(s)

D13721

UniProtKB/Swiss-Prot

P98152

Related

ENSGALP00000047666.2, ENSGALT00000062215.2

Conserved Domains (2) summary

cd07885
Location:25 → 192

RHD-n_RelA; N-terminal sub-domain of the Rel homology domain (RHD) of RelA

pfam16179
Location:200 → 296

RHD_dimer; Rel homology dimerization domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

NC_008465.4 Reference GRCg6a Primary Assembly

Range

6490052..6498329 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_025145278.1 → XP_025001046.1 transcription factor p65 isoform X1

Conserved Domains (2) summary

cd07885
Location:26 → 193

RHD-n_RelA; N-terminal sub-domain of the Rel homology domain (RHD) of RelA

pfam16179
Location:201 → 297

RHD_dimer; Rel homology dimerisation domain