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RELA RELA proto-oncogene, NF-kB subunit [ Gallus gallus (chicken) ]

Gene ID: 396027, updated on 13-Dec-2020

Summary

Symbol
RELAprovided by CGNC
Full Name
RELA proto-oncogene, NF-kB subunitprovided by CGNC
Primary source
CGNC:49615
See related
Ensembl:ENSGALG00000039409
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
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Genomic context

See RELA in Genome Data Viewer
Location:
chromosome: 33
Exon count:
11
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 33 NC_008465.4 (6490052..6498329, complement)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) Unplaced Scaffold NT_464141.1 (65521..73783)
102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) Unplaced Scaffold NW_003779054.1 (164..1087, complement)

Chromosome 33 - NC_008465.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107050176 Neighboring gene uncharacterized LOC107050177 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 3 Neighboring gene lysine acetyltransferase 5 Neighboring gene transmembrane protein 223 Neighboring gene nuclear RNA export factor 1

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MyD88-dependent toll-like receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
NIK/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
NF-kappaB complex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transcription factor p65
Names
NF-kB p65 subunit
nuclear factor NF-kappa-B p65 subunit
v-rel avian reticuloendotheliosis viral oncogene homolog A
v-rel reticuloendotheliosis viral oncogene homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205129.1NP_990460.1  transcription factor p65

    See identical proteins and their annotated locations for NP_990460.1

    Status: PROVISIONAL

    Source sequence(s)
    D13721
    UniProtKB/Swiss-Prot
    P98152
    Related
    ENSGALP00000047666.2, ENSGALT00000062215.2
    Conserved Domains (2) summary
    cd07885
    Location:25192
    RHD-n_RelA; N-terminal sub-domain of the Rel homology domain (RHD) of RelA
    pfam16179
    Location:200296
    RHD_dimer; Rel homology dimerization domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_008465.4 Reference GRCg6a Primary Assembly

    Range
    6490052..6498329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025145278.1XP_025001046.1  transcription factor p65 isoform X1

    Conserved Domains (2) summary
    cd07885
    Location:26193
    RHD-n_RelA; N-terminal sub-domain of the Rel homology domain (RHD) of RelA
    pfam16179
    Location:201297
    RHD_dimer; Rel homology dimerisation domain
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