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ACTN4 actinin, alpha 4 [ Gallus gallus (chicken) ]

Gene ID: 396024, updated on 5-Sep-2025
Official Symbol
ACTN4provided by CGNC
Official Full Name
actinin, alpha 4provided by CGNC
Primary source
CGNC:49612
See related
Ensembl:ENSGALG00010009277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Annotation information
Annotation category: suggests misassembly
Orthologs
human mouse all
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See ACTN4 in Genome Data Viewer
Location:
chromosome: 38
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 38 NC_052569.1 (69182..86492, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 38 NC_052610.1 (116333..134457, complement)

Chromosome 38 - NC_052569.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein L-like Neighboring gene enoyl-CoA hydratase 1 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1-like Neighboring gene eukaryotic translation initiation factor 3 subunit K

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Molecular cloning of low-Ca(2+)-sensitive-type non-muscle alpha-actinin. Imamura M, et al. Eur J Biochem, 1994 Jul 15. PMID 8055908
  2. A novel nonmuscle alpha-actinin. Purification and characterization of chicken lung alpha-actinin. Imamura M, et al. J Biol Chem, 1992 Dec 25. PMID 1334489
  3. Interaction of the enteropathogenic Escherichia coli protein, translocated intimin receptor (Tir), with focal adhesion proteins. Freeman NL, et al. Cell Motil Cytoskeleton, 2000 Dec. PMID 11093251
  4. An expressed sequence tag analysis of the chicken reproductive tract transcriptome. Froman DP, et al. Poult Sci, 2006 Aug. PMID 16903475
  5. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle cell development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
alpha-actinin-4
Names
F-actin cross-linking protein
alpha-actinin
non-muscle alpha-actinin 4
NP_001382966.1

Length

  • 904

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396037.1 → NP_001382966.1  alpha-actinin-4

    Status: VALIDATED

    Source sequence(s)
    BU234602, BU294239, D26597, DR429720, DT658944
    UniProtKB/Swiss-Prot
    Q90734
    UniProtKB/TrEMBL
    A0A8V0Y5A6
    Related
    ENSGALP00010012700.1, ENSGALT00010022136.1
    Conserved Domains (3) summary
    PTZ00184
    Location:752 → 861
    PTZ00184; calmodulin; Provisional
    COG5069
    Location:41 → 405
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:407 → 633
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052569.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    69182..86492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052610.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    116333..134457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934374.1 → XP_046790330.1  alpha-actinin-4 isoform X6

    UniProtKB/TrEMBL
    A0A8V0Y5A6

  2. XM_046934372.1 → XP_046790328.1  alpha-actinin-4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y5A6

  3. XM_046934371.1 → XP_046790327.1  alpha-actinin-4 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y5A6

  4. XM_046934370.1 → XP_046790326.1  alpha-actinin-4 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y5A6

  5. XM_046934373.1 → XP_046790329.1  alpha-actinin-4 isoform X5

    UniProtKB/TrEMBL
    A0A8V0Y5A6

  6. XM_046934369.1 → XP_046790325.1  alpha-actinin-4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y5A6

  7. XM_046934375.1 → XP_046790331.1  alpha-actinin-4 isoform X7

    UniProtKB/TrEMBL
    A0A8V0Y5A6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_205126.1: Suppressed sequence

    Description
    NM_205126.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90734.1 GenPept UniProtKB/Swiss-Prot:Q90734

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials