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VDR vitamin D (1,25- dihydroxyvitamin D3) receptor [ Gallus gallus (chicken) ]

Gene ID: 395988, updated on 19-Sep-2023

Summary

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Symbol
VDRprovided by CGNC
Full Name
vitamin D (1,25- dihydroxyvitamin D3) receptorprovided by CGNC
Primary source
CGNC:10190
See related
Ensembl:ENSGALG00010024416
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See VDR in Genome Data Viewer
Location:
chromosome: 34
Exon count:
16
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 34 NC_052565.1 (1098821..1128668, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 34 NC_052606.1 (1042532..1072353, complement)

Chromosome 34 - NC_052565.1Genomic Context describing neighboring genes Neighboring gene aladin WD repeat nucleoporin Neighboring gene C12orf10 homolog Neighboring gene transmembrane protein 106C Neighboring gene collagen type II alpha 1 chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association of a marker in the vitamin D receptor gene with Marek's disease resistance in poultry. Praslickova D, et al. Poult Sci, 2008 Jun. PMID 18492999
  2. Distribution of vitamin D3 receptor in the epididymal region of roosters (Gallus domesticus) is cell and segment specific. Dornas RA, et al. Gen Comp Endocrinol, 2007 Feb. PMID 17156784
  3. Cloning and origin of the two forms of chicken vitamin D receptor. Lu Z, et al. Arch Biochem Biophys, 1997 Mar 1. PMID 9056239
  4. Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. McDonnell DP, et al. Science, 1987 Mar 6. PMID 3029866
  5. TRPC3-like protein and vitamin D receptor mediate 1alpha,25(OH)2D3-induced SOC influx in muscle cells. Santillán G, et al. Int J Biochem Cell Biol, 2004 Oct. PMID 15203106

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The knockdown of chicken PIWIL1 and PIWIL2 decreased the expression of piRNA-linked gene VDR in the primordial germ cells.
    Title: Small non-coding RNA profiling and the role of piRNA pathway genes in the protection of chicken primordial germ cells.
  2. Analysus of 3 uncorrelated genetic markers (single nucleotide polymorphisms) in the vitamin D receptor gene for association with Marek's disease resistance.
    Title: Association of a marker in the vitamin D receptor gene with Marek's disease resistance in poultry.
  3. Differential VDR expression in the epididymal region segments reveals that several extratesticular ducts may be targets for vitamin D3 action; vitamin D3 may have a regional-specific function, such as calcium transport.
    Title: Distribution of vitamin D3 receptor in the epididymal region of roosters (Gallus domesticus) is cell and segment specific.
  4. endogenous TRPC3-like proteins and the VDR participate in the modulation of CCE by 1alpha,25(OH)2D3 in muscle cells, which could be mediated by an interaction between these proteins
    Title: TRPC3-like protein and vitamin D receptor mediate 1alpha,25(OH)2D3-induced SOC influx in muscle cells.
  5. Polymorphisms within the VDR gene are associated with bone mineral content of the humerus at 35 weeks of age.
    Title: Polymorphisms in vitamin D receptor, osteopontin, insulin-like growth factor 1 and insulin, and their associations with bone, egg and growth traits in a layer--broiler cross in chickens.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables vitamin D response element binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
vitamin D3 receptor
Names
1,25-dihydroxyvitamin D3 receptor
nuclear receptor subfamily 1 group I member 1
vitamin D receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205098.2 → NP_990429.2  vitamin D3 receptor

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000489
    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A8V0ZSB9
    Related
    ENSGALP00010036378.1, ENSGALT00010059574.1
    Conserved Domains (2) summary
    cd06933
    Location:147 → 450
    NR_LBD_VDR; The ligand binding domain of vitamin D receptors, a member of the nuclear receptor superfamily
    cd06955
    Location:39 → 145
    NR_DBD_VDR; DNA-binding domain of vitamin D receptors (VDR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052565.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1098821..1128668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015272604.4 → XP_015128090.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A1D5PI18, A0A8V0ZSB9
    Related
    ENSGALP00010036375.1, ENSGALT00010059571.1
    Conserved Domains (2) summary
    cd06933
    Location:147 → 450
    NR_LBD_VDR; The ligand binding domain of vitamin D receptors, a member of the nuclear receptor superfamily
    cd06955
    Location:39 → 145
    NR_DBD_VDR; DNA-binding domain of vitamin D receptors (VDR) is composed of two C4-type zinc fingers

  2. XM_046904956.1 → XP_046760912.1  vitamin D3 receptor isoform X2

    UniProtKB/Swiss-Prot
    O42392

  3. XM_046904950.1 → XP_046760906.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A8V0ZSB9

  4. XM_046904948.1 → XP_046760904.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A8V0ZSB9

  5. XM_046904954.1 → XP_046760910.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A8V0ZSB9

  6. XM_046904953.1 → XP_046760909.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A8V0ZSB9

  7. XM_046904952.1 → XP_046760908.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A8V0ZSB9

  8. XM_046904951.1 → XP_046760907.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A8V0ZSB9

  9. XM_046904949.1 → XP_046760905.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A8V0ZSB9

  10. XM_046904955.1 → XP_046760911.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A8V0ZSB9

  11. XM_015272605.4 → XP_015128091.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A1D5PI18, A0A8V0ZSB9
    Conserved Domains (2) summary
    cd06933
    Location:147 → 450
    NR_LBD_VDR; The ligand binding domain of vitamin D receptors, a member of the nuclear receptor superfamily
    cd06955
    Location:39 → 145
    NR_DBD_VDR; DNA-binding domain of vitamin D receptors (VDR) is composed of two C4-type zinc fingers

  12. XM_015272607.4 → XP_015128093.1  vitamin D3 receptor isoform X3

    UniProtKB/Swiss-Prot
    O42392
    UniProtKB/TrEMBL
    A0A1D5NUY7
    Conserved Domains (2) summary
    cd06933
    Location:79 → 382
    NR_LBD_VDR; The ligand binding domain of vitamin D receptors, a member of the nuclear receptor superfamily
    cl02596
    Location:5 → 77
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052606.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1042532..1072353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934181.1 → XP_046790137.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392

  2. XM_046934192.1 → XP_046790148.1  vitamin D3 receptor isoform X2

    UniProtKB/Swiss-Prot
    O42392

  3. XM_046934184.1 → XP_046790140.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392

  4. XM_046934182.1 → XP_046790138.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392

  5. XM_046934189.1 → XP_046790145.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392

  6. XM_046934187.1 → XP_046790143.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392

  7. XM_046934186.1 → XP_046790142.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392

  8. XM_046934185.1 → XP_046790141.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392

  9. XM_046934183.1 → XP_046790139.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392

  10. XM_046934190.1 → XP_046790146.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392

  11. XM_046934191.1 → XP_046790147.1  vitamin D3 receptor isoform X1

    UniProtKB/Swiss-Prot
    O42392

  12. XM_046934193.1 → XP_046790149.1  vitamin D3 receptor isoform X3

    UniProtKB/Swiss-Prot
    O42392
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O42392.1 GenPept UniProtKB/Swiss-Prot:O42392

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