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SCN2A sodium voltage-gated channel alpha subunit 2 [ Gallus gallus (chicken) ]

Gene ID: 395945, updated on 13-Apr-2026
Symbol
SCN2Aprovided by CGNC
Full Name
sodium voltage-gated channel alpha subunit 2provided by CGNC
Primary source
CGNC:49566
See related
Ensembl:ENSGALG00010025597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SCN2A in Genome Data Viewer
Location:
chromosome: 7
Exon count:
29
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (19439332..19512749, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (19354821..19428241, complement)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 3 Neighboring gene cysteine and serine rich nuclear protein 3 Neighboring gene uncharacterized LOC107053842 Neighboring gene sodium voltage-gated channel alpha subunit 3 Neighboring gene solute carrier family 38 member 11

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of genes differentially expressed by nerve growth factor- and neurotrophin-3-dependent sensory neurons. Friedel RH, et al. Proc Natl Acad Sci U S A, 1997 Nov 11. PMID 9356508, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane depolarization during action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
sodium channel protein type 2 subunit alpha
Names
sodium channel, voltage-gated, type II, alpha subunit
voltage-gated sodium channel II

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293281.2 → NP_001280210.1  sodium channel protein type 2 subunit alpha

    See identical proteins and their annotated locations for NP_001280210.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    A0A8V1A605, E1BQT2
    Related
    ENSGALP00010038634.1, ENSGALT00010062476.1
    Conserved Domains (5) summary
    cd13433
    Location:1475 → 1527
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1226 → 1483
    Ion_trans; Ion transport protein
    pfam06512
    Location:998 → 1204
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:515 → 630
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1799 → 1854
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    19439332..19512749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004942787.4 → XP_004942844.1  sodium channel protein type 2 subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_004942844.1

    UniProtKB/TrEMBL
    A0A8V1A5Z8, A0A8V1A605
    Conserved Domains (5) summary
    cd13433
    Location:1486 → 1538
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1237 → 1494
    Ion_trans; Ion transport protein
    pfam06512
    Location:1009 → 1215
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:515 → 630
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1810 → 1865
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_046943461.1 → XP_046799417.1  sodium channel protein type 2 subunit alpha isoform X6

    UniProtKB/TrEMBL
    A0A8V1A605

  3. XM_046943458.1 → XP_046799414.1  sodium channel protein type 2 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8V1A605, E1BQT2

  4. XM_046943460.1 → XP_046799416.1  sodium channel protein type 2 subunit alpha isoform X5

    UniProtKB/TrEMBL
    A0A8V1A605

  5. XM_040703343.2 → XP_040559277.1  sodium channel protein type 2 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V1A605
    Conserved Domains (6) summary
    smart00015
    Location:1916 → 1938
    IQ; Calmodulin-binding motif
    cd13433
    Location:1486 → 1538
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1219 → 1494
    Ion_trans; Ion transport protein
    pfam06512
    Location:1009 → 1215
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:515 → 721
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1810 → 1857
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_046943462.1 → XP_046799418.1  sodium channel protein type 2 subunit alpha isoform X7

    UniProtKB/TrEMBL
    A0A8V1A605
    Related
    ENSGALP00010038633.1, ENSGALT00010062473.1

  7. XM_046943459.1 → XP_046799415.1  sodium channel protein type 2 subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8V1A605

  8. XM_046943457.1 → XP_046799413.1  sodium channel protein type 2 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8V1A5Z8, A0A8V1A605
    Related
    ENSGALP00010038628.1, ENSGALT00010062468.1

  9. XM_040703344.2 → XP_040559278.1  sodium channel protein type 2 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V1A605
    Conserved Domains (6) summary
    smart00015
    Location:1916 → 1938
    IQ; Calmodulin-binding motif
    cd13433
    Location:1486 → 1538
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1219 → 1494
    Ion_trans; Ion transport protein
    pfam06512
    Location:1009 → 1215
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:515 → 721
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1810 → 1857
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    19354821..19428241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046921081.1 → XP_046777037.1  sodium channel protein type 2 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8V1A5Z8, A0A8V1A605

  2. XM_046921086.1 → XP_046777042.1  sodium channel protein type 2 subunit alpha isoform X6

    UniProtKB/TrEMBL
    A0A8V1A605

  3. XM_046921083.1 → XP_046777039.1  sodium channel protein type 2 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8V1A605, E1BQT2

  4. XM_046921085.1 → XP_046777041.1  sodium channel protein type 2 subunit alpha isoform X5

    UniProtKB/TrEMBL
    A0A8V1A605

  5. XM_046921079.1 → XP_046777035.1  sodium channel protein type 2 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V1A605

  6. XM_046921087.1 → XP_046777043.1  sodium channel protein type 2 subunit alpha isoform X7

    UniProtKB/TrEMBL
    A0A8V1A605

  7. XM_046921084.1 → XP_046777040.1  sodium channel protein type 2 subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8V1A605

  8. XM_046921080.1 → XP_046777036.1  sodium channel protein type 2 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8V1A5Z8, A0A8V1A605

  9. XM_046921082.1 → XP_046777038.1  sodium channel protein type 2 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V1A605
Nucleotide Protein Strain
Heading Accession and Version

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