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PAX7 paired box 7 [ Gallus gallus (chicken) ]

Gene ID: 395942, updated on 5-Sep-2025
Official Symbol
PAX7provided by CGNC
Official Full Name
paired box 7provided by CGNC
Primary source
CGNC:49563
See related
Ensembl:ENSGALG00010020440
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PAX-7
Orthologs
human mouse all
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See PAX7 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 21 NC_052552.1 (4439660..4528806)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 21 NC_052593.1 (4472842..4561983)

Chromosome 21 - NC_052552.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112530148 Neighboring gene microfibrillar associated protein 2 Neighboring gene ATPase 13A2 Neighboring gene uncharacterized LOC121107387 Neighboring gene uncharacterized LOC107054911 Neighboring gene aldehyde dehydrogenase 4 family member A1 Neighboring gene intermediate filament family orphan 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A novel 31-bp indel in the paired box 7 (PAX7) gene is associated with chicken performance traits. Zhang S, et al. Br Poult Sci, 2014 Feb. PMID 24251689
  2. Identification and expression profile of a novel alternative splicing of Pax7 in chick skeletal muscle. Mao C, et al. Poult Sci, 2008 Sep. PMID 18753463
  3. Pax7 reveals a greater frequency and concentration of satellite cells at the ends of growing skeletal muscle fibers. Allouh MZ, et al. J Histochem Cytochem, 2008 Jan. PMID 17938281, Free PMC Article
  4. Specification of the neural crest occurs during gastrulation and requires Pax7. Basch ML, et al. Nature, 2006 May 11. PMID 16688176
  5. A multiphasic role for Pax7 in tectal development. Thomas M, et al. Exp Brain Res, 2006 Feb. PMID 16429269

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pax7 interacts with Pax3 to regulate morphogenesis and cell differentiation in the developing spinal cord.
    Title: Pax3 and Pax7 interact reciprocally and regulate the expression of cadherin-7 through inducing neuron differentiation in the developing chicken spinal cord.
  2. A 31-bp indel in intron 3 of the PAX7 gene was associated with chicken growth, carcass and meat quality traits where the 31-bp deletion had a negative effect on chicken growth and carcass traits and positive effect on meat quality traits.
    Title: A novel 31-bp indel in the paired box 7 (PAX7) gene is associated with chicken performance traits.
  3. PAX3 and PAX7 mRNA abundance increases with age were less pronounced in caged system chickens than in pen and free-range chickens from day 56 to 84; free-range chickens showed more pronounced increase in gene expression with age than did pen chickens.
    Title: Housing system influences abundance of Pax3 and Pax7 in postnatal chicken skeletal muscles.
  4. cMyb is identified as a novel regulator of Pax7 in early neural crest development.
    Title: Pax7 is regulated by cMyb during early neural crest development through a novel enhancer.
  5. The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression.
    Title: Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development.
  6. Myf5 was detected strictly within Pax7(+) cells and decreased during S phase while MyoD presence persisted in cycling cells
    Title: A distinct profile of myogenic regulatory factor detection within Pax7+ cells at S phase supports a unique role of Myf5 during posthatch chicken myogenesis.
  7. The expression of alternative splicing forms of PAX7 during growth and development of chicks is reported.
    Title: Identification and expression profile of a novel alternative splicing of Pax7 in chick skeletal muscle.
  8. Studies show the existence of distinct subpopulations of cells in the somite and developing limb that are defined by the relative expression levels of Pax7, and that Pax3 and Pax7 negatively regulate each other's expression in the dermomyotome.
    Title: Identification and characterization of subpopulations of Pax3 and Pax7 expressing cells in developing chick somites and limb buds.
  9. Pax7 is initially expressed in the majority of proliferative neuroepithelial cells and later in a subset of neurons of the sgfs laminae.
    Title: A multiphasic role for Pax7 in tectal development.
  10. SCs were localized by their Pax7 expression.
    Title: Pax7 reveals a greater frequency and concentration of satellite cells at the ends of growing skeletal muscle fibers.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
paired box protein Pax-7
Names
paired box gene 7

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205065.1 → NP_990396.1  paired box protein Pax-7

    See identical proteins and their annotated locations for NP_990396.1

    Status: PROVISIONAL

    Source sequence(s)
    D87838
    UniProtKB/TrEMBL
    A0A8V0ZED3, O42349
    Related
    ENSGALP00010029213.1, ENSGALT00010049430.1
    Conserved Domains (3) summary
    smart00351
    Location:34 → 159
    PAX; Paired Box domain
    pfam00046
    Location:218 → 271
    Homeobox; Homeobox domain
    pfam12360
    Location:352 → 382
    Pax7; Paired box protein 7

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4439660..4528806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015296830.4 → XP_015152316.1  paired box protein Pax-7 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZKR8
    Related
    ENSGALP00010029219.1, ENSGALT00010049441.1
    Conserved Domains (3) summary
    cd00131
    Location:34 → 163
    PAX; Paired Box domain
    pfam00046
    Location:220 → 273
    Homeobox; Homeobox domain
    pfam12360
    Location:354 → 384
    Pax7; Paired box protein 7

  2. XM_015296832.4 → XP_015152318.1  paired box protein Pax-7 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZKR8, A5GZA7, F1NYC8
    Conserved Domains (3) summary
    cd00131
    Location:34 → 161
    PAX; Paired Box domain
    pfam00046
    Location:218 → 271
    Homeobox; Homeobox domain
    pfam12360
    Location:352 → 382
    Pax7; Paired box protein 7

  3. XM_015296831.4 → XP_015152317.1  paired box protein Pax-7 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZKR8
    Conserved Domains (3) summary
    cd00131
    Location:34 → 162
    PAX; Paired Box domain
    pfam00046
    Location:219 → 272
    Homeobox; Homeobox domain
    pfam12360
    Location:353 → 383
    Pax7; Paired box protein 7

  4. XM_025142486.3 → XP_024998254.1  paired box protein Pax-7 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZKR8
    Conserved Domains (3) summary
    cd00131
    Location:34 → 160
    PAX; Paired Box domain
    pfam12360
    Location:351 → 381
    Pax7; Paired box protein 7
    pfam00046
    Location:217 → 270
    Homeobox; Homeobox domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4472842..4561983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046931151.1 → XP_046787107.1  paired box protein Pax-7 isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZED3

  2. XM_046931153.1 → XP_046787109.1  paired box protein Pax-7 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZKR8

  3. XM_046931155.1 → XP_046787111.1  paired box protein Pax-7 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZKR8, A5GZA7, F1NYC8

  4. XM_046931154.1 → XP_046787110.1  paired box protein Pax-7 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZKR8

  5. XM_046931152.1 → XP_046787108.1  paired box protein Pax-7 isoform X6

    UniProtKB/TrEMBL
    A0A8V0ZED3

  6. XM_046931156.1 → XP_046787112.1  paired box protein Pax-7 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZKR8
Nucleotide Protein Strain
Heading Accession and Version

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