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HGF hepatocyte growth factor [ Gallus gallus (chicken) ]

Gene ID: 395941, updated on 5-Sep-2025
Symbol
HGFprovided by CGNC
Full Name
hepatocyte growth factorprovided by CGNC
Primary source
CGNC:49562
See related
Ensembl:ENSGALG00010010439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
HGF/SF
Orthologs
human mouse all
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See HGF in Genome Data Viewer
Location:
chromosome: 1
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (10859559..10922316)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (10989211..11052223)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene uncharacterized LOC112532984 Neighboring gene uncharacterized LOC112532986 Neighboring gene uncharacterized LOC107057089 Neighboring gene uncharacterized LOC112532771 Neighboring gene uncharacterized LOC121109473 Neighboring gene uncharacterized LOC121109475

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulation. Streit A, et al. Development, 1995 Mar. PMID 7720585
  2. VEGF-A/HGF induce Prox-1 expression in the chick embryo chorioallantoic membrane lymphatic vasculature. Cimpean AM, et al. Clin Exp Med, 2010 Sep. PMID 20033752
  3. Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions during early chick development. Théry C, et al. Dev Genet, 1995. PMID 7554499
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
hepatocyte growth factor
Names
HGF alpha-chain
hepatocyte growth factor (hepapoietin A; scatter factor)
hepatocyte growth factor /scatter factor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030370.5 → NP_001025541.3  hepatocyte growth factor precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/TrEMBL
    A0A8V0Y9C1, Q90866, Q90978
    Related
    ENSGALP00010014196.1, ENSGALT00010024987.1
    Conserved Domains (4) summary
    smart00020
    Location:492 → 716
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:206 → 285
    KR; Kringle domain
    cd00108
    Location:384 → 467
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd01099
    Location:35 → 118
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10859559..10922316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046911517.1 → XP_046767473.1  hepatocyte growth factor isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y734

  2. XM_015300944.4 → XP_015156430.2  hepatocyte growth factor isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y734
    Related
    ENSGALP00010014190.1, ENSGALT00010024976.1
    Conserved Domains (4) summary
    smart00020
    Location:448 → 672
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:162 → 241
    KR; Kringle domain
    cd00108
    Location:340 → 423
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd01099
    Location:1 → 74
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...

  3. XM_015300900.4 → XP_015156386.2  hepatocyte growth factor isoform X1

    UniProtKB/TrEMBL
    Q90866, Q90978
    Conserved Domains (4) summary
    smart00020
    Location:487 → 711
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:201 → 280
    KR; Kringle domain
    cd00108
    Location:379 → 462
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd01099
    Location:35 → 118
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...

  4. XM_040656097.2 → XP_040512031.1  hepatocyte growth factor isoform X4

    UniProtKB/TrEMBL
    Q90866, Q90978
    Conserved Domains (4) summary
    smart00130
    Location:206 → 285
    KR; Kringle domain
    cd00108
    Location:384 → 467
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd01099
    Location:35 → 118
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
    cl21584
    Location:492 → 620
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. XR_001470741.4 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10989211..11052223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906744.1 → XP_046762700.1  hepatocyte growth factor isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y734

  2. XM_046906745.1 → XP_046762701.1  hepatocyte growth factor isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y734

  3. XM_046906743.1 → XP_046762699.1  hepatocyte growth factor isoform X1

    UniProtKB/TrEMBL
    Q90866, Q90978

RNA

  1. XR_006932642.1 RNA Sequence

  2. XR_006932643.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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