U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AKT1 AKT serine/threonine kinase 1 [ Gallus gallus (chicken) ]

Gene ID: 395928, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Symbol
AKT1provided by CGNC
Full Name
AKT serine/threonine kinase 1provided by CGNC
Primary source
CGNC:49557
See related
Ensembl:ENSGALG00010017364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See AKT1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
17
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (51102404..51173536, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (51080927..51152066, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene adenylosuccinate synthase 1 Neighboring gene SIVA1 apoptosis inducing factor Neighboring gene uncharacterized LOC121110847 Neighboring gene microRNA 1771 Neighboring gene zinc finger and BTB domain containing 42 Neighboring gene uncharacterized LOC121110849

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. AKT signaling mediates IGF-I survival actions on otic neural progenitors. Aburto MR, et al. PLoS One, 2012. PMID 22292041, Free PMC Article
  2. The PI3K/Akt pathway is involved in early infection of some exogenous avian leukosis viruses. Feng SZ, et al. J Gen Virol, 2011 Jul. PMID 21450945
  3. Copper or/and arsenic induces autophagy by oxidative stress-related PI3K/AKT/mTOR pathways and cascaded mitochondrial fission in chicken skeletal muscle. Wang Y, et al. J Inorg Biochem, 2018 Nov. PMID 30096535
  4. Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses. Kang Y, et al. Oncotarget, 2017 Apr 4. PMID 28423596, Free PMC Article
  5. Gene expression pattern of glucose transporters in the skeletal muscles of newly hatched chicks. Shimamoto S, et al. Biosci Biotechnol Biochem, 2016 Jul. PMID 27008100

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-144-3p targets STC1 to activate PI3K/AKT pathway to induce cell apoptosis and cell cycle arrest in selenium deficiency broilers.
    Title: MiR-144-3p targets STC1 to activate PI3K/AKT pathway to induce cell apoptosis and cell cycle arrest in selenium deficiency broilers.
  2. miR-146b-3p is essential for the proliferation, differentiation, and apoptosis of chicken myoblast. Elevated expression of miR-146b-3p can dramatically suppress proliferation and differentiation and facilitate apoptosis of chicken myoblast. Study identified two target genes of miR-146b-3p, AKT1 and MDFIC, and found that miR-146b-3p can inhibit the PI3K/AKT pathway.
    Title: The Inhibition on MDFIC and PI3K/AKT Pathway Caused by miR-146b-3p Triggers Suppression of Myoblast Proliferation and Differentiation and Promotion of Apoptosis.
  3. results showed that after Cu or/and As insult and accumulation, inhibited PI3K/AKT/mTOR pathway activated autophagy and disturbed mitochondrial dynamic, forming a positive feedback with redox disorder.
    Title: Copper or/and arsenic induces autophagy by oxidative stress-related PI3K/AKT/mTOR pathways and cascaded mitochondrial fission in chicken skeletal muscle.
  4. Data suggest that by suppressing premature apoptosis upon Newcastle disease virus (NDV) infection, the PI3K/Akt pathway enhances the anti-apoptotic response.
    Title: Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses.
  5. Phosphorylated AKT level was high in the skeletal muscles, suggesting a relationship between AKT and GLUT1 expression.
    Title: Gene expression pattern of glucose transporters in the skeletal muscles of newly hatched chicks.
  6. Proliferative otic neuroblasts are dependent on the activation of the PI3K-AKT pathway by IGF-I for survival during the otic neuronal progenitor phase of early inner ear development.
    Title: AKT signaling mediates IGF-I survival actions on otic neural progenitors.
  7. The PI3K/Akt pathway is involved in early infection avian leukosis viruses.
    Title: The PI3K/Akt pathway is involved in early infection of some exogenous avian leukosis viruses.
  8. These findings suggest that integrity of the actin cytoskeleton is a crucial requirement for PI3K/Akt and p38 MAPK in chondrocyte redifferentiation.
    Title: Integrity of the cortical actin ring is required for activation of the PI3K/Akt and p38 MAPK signaling pathways in redifferentiation of chondrocytes on chitosan.
  9. Short time exposure to hypoxia increases DNA synthesis in primary cultured chicken hepatocytes through cooperation of Ca2+/PKC, p38 MAPK, p44/42 MAPKs, and PI3K/Akt pathways.
    Title: A potential mechanism for short time exposure to hypoxia-induced DNA synthesis in primary cultured chicken hepatocytes: Correlation between Ca(2+)/PKC/MAPKs and PI3K/Akt/mTOR.
  10. Data suggest that the FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin.
    Title: FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470).
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
RAC-alpha serine/threonine-protein kinase
Names
serine/threonine protein kinase
v-akt murine thymoma viral oncogene homolog 1
NP_001383316.1
NP_001383317.1
NP_990386.2
XP_046773821.1
XP_046773822.1
XP_046797415.1
XP_046797416.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396387.1 → NP_001383316.1  RAC-alpha serine/threonine-protein kinase

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    A0A3Q2U4X3, O57513
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124 → 479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

  2. NM_001396388.1 → NP_001383317.1  RAC-alpha serine/threonine-protein kinase

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    A0A3Q2U4X3, O57513
    Related
    ENSGALP00010024511.1, ENSGALT00010041901.1
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124 → 479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

  3. NM_205055.2 → NP_990386.2  RAC-alpha serine/threonine-protein kinase

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    A0A3Q2U4X3, O57513
    Related
    ENSGALP00010024517.1, ENSGALT00010041909.1
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124 → 479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    51102404..51173536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046941459.1 → XP_046797415.1  RAC-alpha serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A3Q2U4X3
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124 → 479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

  2. XM_046941460.1 → XP_046797416.1  RAC-alpha serine/threonine-protein kinase isoform X2

    Related
    ENSGALP00010024506.1, ENSGALT00010041894.1
    Conserved Domains (2) summary
    cd05594
    Location:62 → 417
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
    cl17171
    Location:1 → 49
    PH-like; Pleckstrin homology-like domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    51080927..51152066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917865.1 → XP_046773821.1  RAC-alpha serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A3Q2U4X3
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124 → 479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

  2. XM_046917866.1 → XP_046773822.1  RAC-alpha serine/threonine-protein kinase isoform X2

    Conserved Domains (2) summary
    cd05594
    Location:62 → 417
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
    cl17171
    Location:1 → 49
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous