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PITX2 paired like homeodomain 2 [ Gallus gallus (chicken) ]

Gene ID: 395862, updated on 2-Oct-2018

Summary

Symbol
PITX2provided by CGNC
Full Name
paired like homeodomain 2provided by CGNC
Primary source
CGNC:66216
See related
Ensembl:ENSGALG00000042492
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
Ptx2
Orthologs

Genomic context

See PITX2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
6
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 4 NC_006091.5 (57785032..57798939)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 4 NC_006091.4 (58166941..58171052)

Chromosome 4 - NC_006091.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112532377 Neighboring gene uncharacterized LOC112532357 Neighboring gene translation initiation factor IF-2-like Neighboring gene glutamyl aminopeptidase Neighboring gene uncharacterized LOC107051706 Neighboring gene ELOVL fatty acid elongase 6

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
determination of left/right symmetry IEP
Inferred from Expression Pattern
more info
PubMed 
embryonic limb morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
embryonic organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart morphogenesis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of dermatome development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of myoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of myotome development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
response to retinoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pituitary homeobox 2
Names
cPITX2
homeobox protein PITX2
paired-like homeodomain transcription factor 2
transcription factor Pitx2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205010.1NP_990341.1  pituitary homeobox 2

    See identical proteins and their annotated locations for NP_990341.1

    Status: PROVISIONAL

    Source sequence(s)
    AF076640
    UniProtKB/Swiss-Prot
    O93385
    Related
    ENSGALP00000046615.1, ENSGALT00000075211.1
    Conserved Domains (3) summary
    pfam00046
    Location:105157
    Homeobox; Homeobox domain
    pfam03826
    Location:291308
    OAR; OAR domain
    pfam06632
    Location:72132
    XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006091.5 Reference GRCg6a Primary Assembly

    Range
    57785032..57798939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025149516.1XP_025005284.1  pituitary homeobox 2 isoform X1

    Conserved Domains (2) summary
    pfam00046
    Location:4395
    Homeobox; Homeobox domain
    pfam03826
    Location:229246
    OAR; OAR domain
  2. XM_025149515.1XP_025005283.1  pituitary homeobox 2 isoform X1

    Conserved Domains (2) summary
    pfam00046
    Location:4395
    Homeobox; Homeobox domain
    pfam03826
    Location:229246
    OAR; OAR domain
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