U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HSPA8 heat shock protein family A (Hsp70) member 8 [ Gallus gallus (chicken) ]

Gene ID: 395853, updated on 5-Sep-2025
Official Symbol
HSPA8provided by CGNC
Official Full Name
heat shock protein family A (Hsp70) member 8provided by CGNC
Primary source
CGNC:49511
See related
Ensembl:ENSGALG00010025592
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
HSC70
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See HSPA8 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
9
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 24 NC_052555.1 (3128643..3133770)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 24 NC_052596.1 (3088104..3093250)

Chromosome 24 - NC_052555.1Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel beta subunit 3 Neighboring gene GRAM domain containing 1B Neighboring gene CXADR like membrane protein Neighboring gene uncharacterized LOC124417388 Neighboring gene small nucleolar RNA SNORD14 Neighboring gene small nucleolar RNA SNORD14 Neighboring gene small nucleolar RNA SNORD14 Neighboring gene brain specific homeobox Neighboring gene junctional cadherin complex regulator

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. HSC70 is required for infectious bursal disease virus (IBDV) infection in DF-1 cells. Chen C, et al. Virol J, 2020 May 6. PMID 32375812, Free PMC Article
  2. Gallus Heat shock cognate protein 70, a novel binding partner of Apoptin. Chen K, et al. Virol J, 2011 Jun 27. PMID 21707973, Free PMC Article
  3. Modulation of the chaperone heat shock cognate 70 by embryonic (pro)insulin correlates with prevention of apoptosis. de la Rosa EJ, et al. Proc Natl Acad Sci U S A, 1998 Aug 18. PMID 9707581, Free PMC Article
  4. Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70. Smith DF, et al. Mol Cell Biol, 1993 Feb. PMID 8423808, Free PMC Article
  5. Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Galan JA, et al. J Am Soc Mass Spectrom, 2011 Feb. PMID 21472591, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HSC70 is required for infectious bursal disease virus (IBDV) infection in DF-1 cells.
    Title: HSC70 is required for infectious bursal disease virus (IBDV) infection in DF-1 cells.
  2. These data demonstrate that Hsc70 is responsible for the down-regulation of Apoptin induced RelA/p65 gene expression.
    Title: Gallus Heat shock cognate protein 70, a novel binding partner of Apoptin.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables misfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein refolding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
heat shock cognate 71 kDa protein
Names
heat shock 70kDa protein 8
heat shock cognate 70
NP_990334.2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205003.3 → NP_990334.2  heat shock cognate 71 kDa protein

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000341
    UniProtKB/Swiss-Prot
    O73885
    Related
    ENSGALP00010038630.1, ENSGALT00010062470.1
    Conserved Domains (1) summary
    PTZ00009
    Location:1 → 613
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3128643..3133770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052596.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    3088104..3093250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O73885.1 GenPept UniProtKB/Swiss-Prot:O73885

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials