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GJA8 gap junction protein alpha 8 [ Gallus gallus (chicken) ]

Gene ID: 395846, updated on 20-Jun-2018

Summary

Symbol
GJA8provided by CGNC
Full Name
gap junction protein alpha 8provided by CGNC
Primary source
CGNC:11546
See related
Ensembl:ENSGALG00000015488
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
Cx50; Cx45.6; connexin-45.6
Orthologs

Genomic context

See GJA8 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 1 NC_006088.5 (93850707..93899333)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 1 NC_006088.4 (92445646..92494209)

Chromosome 1 - NC_006088.5Genomic Context describing neighboring genes Neighboring gene acid phosphatase 6, lysophosphatidic Neighboring gene uncharacterized LOC107055079 Neighboring gene gap junction protein alpha 5 Neighboring gene G protein-coupled receptor 89B Neighboring gene PDZ domain containing 1 Neighboring gene cell surface glycoprotein CD200 receptor 1-A-like

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell communication IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
connexin complex IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gap junction alpha-8 protein
Names
connexin 45.6
connexin 50

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204997.1NP_990328.1  gap junction alpha-8 protein

    See identical proteins and their annotated locations for NP_990328.1

    Status: PROVISIONAL

    Source sequence(s)
    L24799
    UniProtKB/Swiss-Prot
    P36381
    Related
    ENSGALP00000036053.1, ENSGALT00000024977.3
    Conserved Domains (5) summary
    smart00037
    Location:4476
    CNX; Connexin homologues
    smart01089
    Location:163229
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:3230
    Connexin; Connexin
    pfam03509
    Location:262325
    Connexin50; Gap junction alpha-8 protein (Cx50)
    pfam16791
    Location:379400
    Connexin40_C; Connexin 40 C-terminal domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006088.5 Reference GRCg6a Primary Assembly

    Range
    93850707..93899333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015295800.2XP_015151286.1  gap junction alpha-8 protein isoform X1

    UniProtKB/TrEMBL
    F1NRH7
    Conserved Domains (5) summary
    smart00037
    Location:4476
    CNX; Connexin homologues
    smart01089
    Location:163229
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:3230
    Connexin; Connexin
    pfam03509
    Location:262325
    Connexin50; Gap junction alpha-8 protein (Cx50)
    pfam16791
    Location:379400
    Connexin40_C; Connexin 40 C-terminal domain
  2. XM_015295814.2XP_015151300.1  gap junction alpha-8 protein isoform X1

    UniProtKB/TrEMBL
    F1NRH7
    Conserved Domains (5) summary
    smart00037
    Location:4476
    CNX; Connexin homologues
    smart01089
    Location:163229
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:3230
    Connexin; Connexin
    pfam03509
    Location:262325
    Connexin50; Gap junction alpha-8 protein (Cx50)
    pfam16791
    Location:379400
    Connexin40_C; Connexin 40 C-terminal domain
  3. XM_015295808.2XP_015151294.1  gap junction alpha-8 protein isoform X1

    UniProtKB/TrEMBL
    F1NRH7
    Conserved Domains (5) summary
    smart00037
    Location:4476
    CNX; Connexin homologues
    smart01089
    Location:163229
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:3230
    Connexin; Connexin
    pfam03509
    Location:262325
    Connexin50; Gap junction alpha-8 protein (Cx50)
    pfam16791
    Location:379400
    Connexin40_C; Connexin 40 C-terminal domain
  4. XM_015295822.2XP_015151308.1  gap junction alpha-8 protein isoform X1

    UniProtKB/TrEMBL
    F1NRH7
    Conserved Domains (5) summary
    smart00037
    Location:4476
    CNX; Connexin homologues
    smart01089
    Location:163229
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:3230
    Connexin; Connexin
    pfam03509
    Location:262325
    Connexin50; Gap junction alpha-8 protein (Cx50)
    pfam16791
    Location:379400
    Connexin40_C; Connexin 40 C-terminal domain
  5. XM_015295825.2XP_015151311.1  gap junction alpha-8 protein isoform X1

    UniProtKB/TrEMBL
    F1NRH7
    Conserved Domains (5) summary
    smart00037
    Location:4476
    CNX; Connexin homologues
    smart01089
    Location:163229
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:3230
    Connexin; Connexin
    pfam03509
    Location:262325
    Connexin50; Gap junction alpha-8 protein (Cx50)
    pfam16791
    Location:379400
    Connexin40_C; Connexin 40 C-terminal domain
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