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SEMA3A semaphorin 3A [ Gallus gallus (chicken) ]

Gene ID: 395825, updated on 13-Apr-2026
Symbol
SEMA3Aprovided by CGNC
Full Name
semaphorin 3Aprovided by CGNC
Primary source
CGNC:4946
See related
Ensembl:ENSGALG00010005470
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
COLL-1; semaphorin-3A
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SEMA3A in Genome Data Viewer
Location:
chromosome: 1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (9286630..9576166)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (9405741..9694848)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121107435 Neighboring gene semaphorin 3D Neighboring gene uncharacterized LOC112532981 Neighboring gene semaphorin 3E Neighboring gene piccolo presynaptic cytomatrix protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Axon guidance in the developing ocular motor system and Duane retraction syndrome depends on Semaphorin signaling via alpha2-chimaerin. Ferrario JE, et al. Proc Natl Acad Sci U S A, 2012 Sep 4. PMID 22912401, Free PMC Article
  2. Semaphorin3A facilitates axonal transport through a local calcium signaling and tetrodotoxin-sensitive voltage-gated sodium channels. Yamane M, et al. Biochem Biophys Res Commun, 2012 Jun 1. PMID 22575508
  3. Lens-derived Semaphorin3A regulates sensory innervation of the cornea. Lwigale PY, et al. Dev Biol, 2007 Jun 15. PMID 17499699
  4. Intrathecally administered Sema3A protein attenuates neuropathic pain behavior in rats with chronic constriction injury of the sciatic nerve. Hayashi M, et al. Neurosci Res, 2011 Jan. PMID 20888378
  5. Developmental guidance of embryonic corneal innervation: roles of Semaphorin3A and Slit2. Kubilus JK, et al. Dev Biol, 2010 Aug 1. PMID 20471970, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest that by interacting with PlexA4, TrkA plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 localization and patterning.
    Title: TrkA mediates retrograde semaphorin 3A signaling through plexin A4 to regulate dendritic branching.
  2. Results indicate that GSK3beta and Axin-1 are involved in Sema3A-induced bidirectional axonal transport
    Title: Semaphorin3A-induced axonal transport mediated through phosphorylation of Axin-1 by GSK3β.
  3. NRP1-mediated Sema3A signals provide repulsive signals for MAP2-positive neurons to segregate tectal layers, which is important in order to coordinate laminar organization of the optic tectum.
    Title: NRP1-mediated Sema3A signals coordinate laminar formation in the developing chick optic tectum.
  4. Axon guidance in the developing ocular motor system and Duane retraction syndrome depends on Semaphorin signaling via alpha2-chimaerin.
    Title: Axon guidance in the developing ocular motor system and Duane retraction syndrome depends on Semaphorin signaling via alpha2-chimaerin.
  5. these results identify a novel mechanism of Sema3A-induced axonal transport, and further suggest that Sema3A-induced local calcium signaling in growth cone is propagated to cell body in a TTX-sensitive manner.
    Title: Semaphorin3A facilitates axonal transport through a local calcium signaling and tetrodotoxin-sensitive voltage-gated sodium channels.
  6. Syx1B is involved in the regulation of macropinocytosis in semaphorin (Sema)3A-induced growth cone collapse.
    Title: Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapse.
  7. Recombinant Sema3A protein attenuated mechanical allodynia and heat hyperalgesia in chronic constriction injury (CCI) rats, whereas heat-inactivated Sema3A had no effect.
    Title: Intrathecally administered Sema3A protein attenuates neuropathic pain behavior in rats with chronic constriction injury of the sciatic nerve.
  8. Semaphorin3A and Slit2 have roles in developmental guidance of embryonic corneal innervation
    Title: Developmental guidance of embryonic corneal innervation: roles of Semaphorin3A and Slit2.
  9. Sema3A overexpression induced defasciculation and exuberant growth of motor axon projections into these normally non-permissive territories.
    Title: Semaphorin and neuropilin co-expression in motoneurons sets axon sensitivity to environmental semaphorin sources during motor axon pathfinding.
  10. Results suggest a molecular mechanism whereby ingrowth of retinal axons into the tectum can be regulated by semaphorin 3E/BDNF modulation without disturbing tectal axon growth out of the tectum mediated by Sema3A.
    Title: Differential impact of semaphorin 3E and 3A on CNS axons.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chemorepellent activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neuropilin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables semaphorin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
semaphorin-3A
Names
collapsin
collapsin-1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204977.1 → NP_990308.2  semaphorin-3A precursor

    Status: PROVISIONAL

    Source sequence(s)
    U02528
    UniProtKB/TrEMBL
    F1NVZ5
    Related
    ENSGALP00010007619.1, ENSGALT00010013057.1
    Conserved Domains (4) summary
    cd05871
    Location:617 → 707
    Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin
    cd11249
    Location:62 → 554
    Sema_3A; The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A)
    smart00410
    Location:622 → 688
    IG_like; Immunoglobulin like
    smart00423
    Location:552 → 588
    PSI; domain found in Plexins, Semaphorins and Integrins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    9286630..9576166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015295177.4 → XP_015150663.1  semaphorin-3A isoform X1

    UniProtKB/Swiss-Prot
    Q90607
    Conserved Domains (3) summary
    cd11249
    Location:26 → 518
    Sema_3A; The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A)
    smart00423
    Location:516 → 552
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd05871
    Location:580 → 671
    Ig_Sema3; Immunoglobulin (Ig)-like domain of class III semaphorin Sema3

  2. XM_040654804.2 → XP_040510738.1  semaphorin-3A isoform X1

    UniProtKB/Swiss-Prot
    Q90607
    Related
    ENSGALP00010007617.1, ENSGALT00010013055.1
    Conserved Domains (3) summary
    cd11249
    Location:26 → 518
    Sema_3A; The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A)
    smart00423
    Location:516 → 552
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd05871
    Location:580 → 671
    Ig_Sema3; Immunoglobulin (Ig)-like domain of class III semaphorin Sema3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    9405741..9694848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906730.1 → XP_046762686.1  semaphorin-3A isoform X1

    UniProtKB/Swiss-Prot
    Q90607

  2. XM_046906729.1 → XP_046762685.1  semaphorin-3A isoform X1

    UniProtKB/Swiss-Prot
    Q90607
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90607.1 GenPept UniProtKB/Swiss-Prot:Q90607

Gene LinkOut

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