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SH2D6 SH2 domain containing 6 [ Gallus gallus (chicken) ]

Gene ID: 395733, updated on 3-Dec-2024
Symbol
SH2D6provided by CGNC
Full Name
SH2 domain containing 6provided by CGNC
Primary source
CGNC:5261
See related
Ensembl:ENSGALG00010021725
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
BASH; BLNK
Orthologs
human mouse all
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See SH2D6 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
29
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (21885597..21981713, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (21776654..21872782, complement)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100859611 Neighboring gene zinc finger protein 518A Neighboring gene cyclin J Neighboring gene DNA nucleotidylexotransferase Neighboring gene heparan sulfate glucosamine 3-O-sulfotransferase 1-like Neighboring gene uncharacterized LOC121113371 Neighboring gene VENT homeobox Neighboring gene microRNA 202

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius. Goitsuka R, et al. J Immunol, 1998 Dec 1. PMID 9834055
  2. BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. Chiu CW, et al. EMBO J, 2002 Dec 2. PMID 12456653, Free PMC Article
  3. BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells. Ishiai M, et al. Immunity, 1999 Jan. PMID 10023776
  4. Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins. Gupta N, et al. Cancer Res, 2008 Feb 1. PMID 18245482, Free PMC Article
  5. Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. Grabbe A, et al. Blood, 2006 Dec 1. PMID 16912232

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In hydrogen peroxide-stimulated DT40 cells, BLNK is phosphorylated by Syk and not by Btk.
    Title: Bruton's tyrosine kinase is essential for hydrogen peroxide-induced calcium signaling.
  2. Microarray analysis of SCA-2 induced bursal cells showed BLNK to be among the under-expressed genes and this was validated with qRT-PCR.
    Title: Cloning and functional characterization of chicken stem cell antigen 2.
  3. BLNK recruits active H-Ras to the BCR complex, which is essential for sustained surface expression of BCR in the form of the cap and for the signal leading to functional ERK activation
    Title: BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation.
  4. short SLP-65 isoform promotes BCR-induced B-cell apoptosis
    Title: Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
B-cell linker protein
Names
B cell linker protein BLNK
B-cell adapter SH2 domain-containing protein
SLP-65
cytoplasmic adapter protein
src homology 2 domain-containing leukocyte protein of 65 kDa

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204908.2 → NP_990239.1  B-cell linker protein

    See identical proteins and their annotated locations for NP_990239.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000232
    UniProtKB/Swiss-Prot
    Q9YGC1
    UniProtKB/TrEMBL
    A0A8V0ZK13
    Conserved Domains (1) summary
    cd09929
    Location:430 → 550
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    21885597..21981713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046942733.1 → XP_046798689.1  B-cell linker protein isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZSI0

  2. XM_046942732.1 → XP_046798688.1  B-cell linker protein isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZLS5, A0A8V0ZSI0
    Related
    ENSGALP00010031760.1, ENSGALT00010052854.1

  3. XM_046942731.1 → XP_046798687.1  B-cell linker protein isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZEN1, A0A8V0ZSI0
    Related
    ENSGALP00010031751.1, ENSGALT00010052845.1

  4. XM_025151487.3 → XP_025007255.1  B-cell linker protein isoform X13

    UniProtKB/TrEMBL
    A0A8V0ZEJ3
    Conserved Domains (2) summary
    cd09929
    Location:436 → 556
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    cl26464
    Location:154 → 425
    Atrophin-1; Atrophin-1 family

  5. XM_040702274.2 → XP_040558208.1  B-cell linker protein isoform X8

    UniProtKB/TrEMBL
    A0A8V0ZEJ3
    Conserved Domains (2) summary
    cd09929
    Location:464 → 584
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    PHA03247
    Location:100 → 446
    PHA03247; large tegument protein UL36; Provisional

  6. XM_015288573.4 → XP_015144059.1  B-cell linker protein isoform X11

    UniProtKB/TrEMBL
    A0A8V0ZEJ3
    Related
    ENSGALP00010031716.1, ENSGALT00010052811.1
    Conserved Domains (1) summary
    cd09929
    Location:455 → 575
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

  7. XM_040702273.2 → XP_040558207.1  B-cell linker protein isoform X6

    UniProtKB/TrEMBL
    A0A8V0ZEJ3
    Conserved Domains (2) summary
    cd09929
    Location:483 → 603
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    PHA03247
    Location:119 → 465
    PHA03247; large tegument protein UL36; Provisional

  8. XM_015288572.4 → XP_015144058.1  B-cell linker protein isoform X10

    UniProtKB/TrEMBL
    A0A8V0ZEM2
    Related
    ENSGALP00010031741.1, ENSGALT00010052835.1
    Conserved Domains (3) summary
    smart00454
    Location:12 → 73
    SAM; Sterile alpha motif
    cd09929
    Location:457 → 577
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    cl15755
    Location:10 → 75
    SAM_superfamily; SAM (Sterile alpha motif )

  9. XM_040702272.2 → XP_040558206.1  B-cell linker protein isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZEM2
    Conserved Domains (3) summary
    cd09929
    Location:485 → 605
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    PHA03247
    Location:121 → 467
    PHA03247; large tegument protein UL36; Provisional
    cl15755
    Location:10 → 75
    SAM_superfamily; SAM (Sterile alpha motif )

  10. XM_015288571.4 → XP_015144057.1  B-cell linker protein isoform X7

    UniProtKB/TrEMBL
    A0A8V0ZEL3
    Related
    ENSGALP00010031731.1, ENSGALT00010052825.1
    Conserved Domains (3) summary
    smart00454
    Location:12 → 73
    SAM; Sterile alpha motif
    cd09929
    Location:476 → 596
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    cl15755
    Location:10 → 75
    SAM_superfamily; SAM (Sterile alpha motif )

  11. XM_040702271.2 → XP_040558205.1  B-cell linker protein isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZEL3
    Conserved Domains (3) summary
    cd09929
    Location:504 → 624
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    PHA03247
    Location:140 → 486
    PHA03247; large tegument protein UL36; Provisional
    cl15755
    Location:10 → 75
    SAM_superfamily; SAM (Sterile alpha motif )

  12. XM_015288574.4 → XP_015144060.1  B-cell linker protein isoform X14

    UniProtKB/TrEMBL
    A0A8V0ZK13
    Conserved Domains (1) summary
    cd09929
    Location:411 → 531
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

  13. XM_040702276.2 → XP_040558210.1  B-cell linker protein isoform X12

    UniProtKB/TrEMBL
    A0A8V0ZK13
    Conserved Domains (2) summary
    cd09929
    Location:439 → 559
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    PHA03247
    Location:75 → 421
    PHA03247; large tegument protein UL36; Provisional

  14. XM_040702275.2 → XP_040558209.1  B-cell linker protein isoform X9

    UniProtKB/TrEMBL
    A0A8V0ZK13, F1NFD7
    Related
    ENSGALP00010031703.1, ENSGALT00010052797.1
    Conserved Domains (2) summary
    cd09929
    Location:458 → 578
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    PHA03247
    Location:94 → 440
    PHA03247; large tegument protein UL36; Provisional

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    21776654..21872782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919910.1 → XP_046775866.1  B-cell linker protein isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZSI0

  2. XM_046919908.1 → XP_046775864.1  B-cell linker protein isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZLS5, A0A8V0ZSI0

  3. XM_046919907.1 → XP_046775863.1  B-cell linker protein isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZEN1, A0A8V0ZSI0

  4. XM_046919919.1 → XP_046775875.1  B-cell linker protein isoform X13

    UniProtKB/TrEMBL
    A0A8V0ZEJ3

  5. XM_046919914.1 → XP_046775870.1  B-cell linker protein isoform X8

    UniProtKB/TrEMBL
    A0A8V0ZEJ3

  6. XM_046919917.1 → XP_046775873.1  B-cell linker protein isoform X11

    UniProtKB/TrEMBL
    A0A8V0ZEJ3

  7. XM_046919912.1 → XP_046775868.1  B-cell linker protein isoform X6

    UniProtKB/TrEMBL
    A0A8V0ZEJ3

  8. XM_046919916.1 → XP_046775872.1  B-cell linker protein isoform X10

    UniProtKB/TrEMBL
    A0A8V0ZEM2

  9. XM_046919911.1 → XP_046775867.1  B-cell linker protein isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZEM2

  10. XM_046919913.1 → XP_046775869.1  B-cell linker protein isoform X7

    UniProtKB/TrEMBL
    A0A8V0ZEL3

  11. XM_046919909.1 → XP_046775865.1  B-cell linker protein isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZEL3

  12. XM_046919920.1 → XP_046775876.1  B-cell linker protein isoform X14

    UniProtKB/TrEMBL
    A0A8V0ZK13

  13. XM_046919918.1 → XP_046775874.1  B-cell linker protein isoform X12

    UniProtKB/TrEMBL
    A0A8V0ZK13

  14. XM_046919915.1 → XP_046775871.1  B-cell linker protein isoform X9

    UniProtKB/TrEMBL
    A0A8V0ZK13, F1NFD7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9YGC1.1 GenPept UniProtKB/Swiss-Prot:Q9YGC1

Gene LinkOut

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