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LGALS2 galectin 2 [ Homo sapiens (human) ]

Gene ID: 3957, updated on 12-Jan-2019

Summary

Official Symbol
LGALS2provided by HGNC
Official Full Name
galectin 2provided by HGNC
Primary source
HGNC:HGNC:6562
See related
Ensembl:ENSG00000100079 MIM:150571
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HL14
Summary
The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]
Expression
Biased expression in gall bladder (RPKM 133.8), small intestine (RPKM 81.3) and 7 other tissues See more
Orthologs

Genomic context

See LGALS2 in Genome Data Viewer
Location:
22q13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (37570246..37580017, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (37966253..37976024, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene CDC42 effector protein 1 Neighboring gene HNF1 motif-containing MPRA enhancer 93 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 1 Neighboring gene uncharacterized LOC101927051 Neighboring gene SH3 domain binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Myocardial infarction 1
MedGen: C1832662 OMIM: 608446 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC75071

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
galactoside binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
galectin-2
Names
S-Lac lectin 2
beta-galactoside-binding lectin L-14-II
gal-2
lactose-binding lectin 2
lectin, galactoside-binding, soluble, 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012096.1 RefSeqGene

    Range
    5001..14772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006498.3NP_006489.1  galectin-2

    See identical proteins and their annotated locations for NP_006489.1

    Status: REVIEWED

    Source sequence(s)
    AL022315, BC059782, CD701729
    Consensus CDS
    CCDS13950.1
    UniProtKB/Swiss-Prot
    P05162
    Related
    ENSP00000215886.4, ENST00000215886.5
    Conserved Domains (1) summary
    cd00070
    Location:11129
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    37570246..37580017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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