Sox21b [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sox21bprovided by FlyBase
Primary source: FLYBASE:FBgn0042630
Locus tag: Dmel_CG32139
See related: AllianceGenome:FB:FBgn0042630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13483; CG32139; CG6419; Dmel\CG32139; Sox B2-2; Sox21B; SoxB2.2; SOXB2.2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and positive regulation of transcription by RNA polymerase II. Is expressed in several structures, including atrium; ectodermal derivative; epidermal cell; imaginal disc; and presumptive embryonic/larval system. Orthologous to several human genes including SOX21 (SRY-box transcription factor 21). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 70D2-70D2; 3-42 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14112405..14131324, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14105505..14124424, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species.
Title: Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2052 (e-PCR)
- UniSTS:21657

Dm1776 (e-PCR)
- UniSTS:76704

Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Sox21b

Names: CG32139-PA; CG32139-PB; CG32139-PC; Sox21b-PA; Sox21b-PB; Sox21b-PC; sox-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

14112405..14131324 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140438.3 → NP_648695.1 Sox21b, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648695.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95U47, Q9VUD3

Related

FBpp0075489

Conserved Domains (1) summary

cd01388
Location:247 → 318

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001274899.1 → NP_001261828.1 Sox21b, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261828.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95U47, Q9VUD3

Conserved Domains (1) summary

cd01388
Location:247 → 318

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001274900.1 → NP_001261829.1 Sox21b, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261829.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCG2

Conserved Domains (1) summary

cd01388
Location:247 → 318

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...