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Sox21a Sox21a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39567, updated on 6-Jul-2026
Official Symbol
Sox21aprovided by FlyBase
Official Full Name
Sox21aprovided by FlyBase
Primary source
FLYBASE:FBgn0036411
Locus tag
Dmel_CG7345
See related
AllianceGenome:FB:FBgn0036411
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7345; Dmel\CG7345; Sox B2-3; Sox21; sox21a; SoxB2.3; SOXB2.3
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in midgut development; negative regulation of cell differentiation; and stem cell proliferation. Located in nucleus. Is expressed in several structures, including enterocyte of posterior adult midgut epithelium; foregut primordium; hindgut proper primordium; somatic precursor cell; and ventral midline of embryo. Used to study intestinal cancer. Orthologous to human SOX14 (SRY-box transcription factor 14) and SOX7 (SRY-box transcription factor 7). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See Sox21a in Genome Data Viewer
Location:
70D2-70D2; 3-42 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14103481..14108118, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14096581..14101218, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Fat body protein 1 Neighboring gene Sox21b Neighboring gene long non-coding RNA:CR45887

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Regulation of intestinal stem cell activity by a mitotic cell cycle regulator Polo in Drosophila. Zhang Y, et al. G3 (Bethesda), 2023 Jun 1. PMID 37154439, Free PMC Article
  2. A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis. Chen J, et al. Elife, 2016 May 17. PMID 27187149, Free PMC Article
  3. Conserved genomic organisation of Group B Sox genes in insects. McKimmie C, et al. BMC Genet, 2005 May 19. PMID 15943880, Free PMC Article
  4. Aging-related peroxisomal dysregulation disrupts intestinal stem cell differentiation through alterations of very long-chain fatty acid oxidation. Guo X, et al. PLoS Biol, 2025 Dec. PMID 41417787, Free PMC Article
  5. A Sox Transcription Factor Is a Critical Regulator of Adult Stem Cell Proliferation in the Drosophila Intestine. Meng FW, et al. Cell Rep, 2015 Nov 3. PMID 26565904

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We further demonstrate that JAK/STAT signaling, Sox21a and GATAe form a functional relay to orchestrate EB differentiation. Thus, our study provides new insights into the complex and sequential events that are required for rapid differentiation following stem cell division during tissue replenishment.
    Title: A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila.
  2. Sox21a is specifically required for adult intestinal stem cell proliferation.
    Title: A Sox Transcription Factor Is a Critical Regulator of Adult Stem Cell Proliferation in the Drosophila Intestine.
  3. This study reports that loss of the SOX transcription factor, Sox21a, blocks the differentiation programme of enteroblast (EB), the intestinal stem cell progeny in the adult Drosophila midgut with subsequent tumor formation.
    Title: Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in midgut development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Sox21a
Names
CG7345-PA
CG7345-PB
Sox21a-PA
Sox21a-PB

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14103481..14108118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140437.2 → NP_648694.1  Sox21a, isoform A

    See identical proteins and their annotated locations for NP_648694.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V719, Q9VUD1
    Related
    FBpp0075490
    Conserved Domains (1) summary
    cd01388
    Location:120 → 191
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

  2. NM_001274898.1 → NP_001261827.1  Sox21a, isoform B

    See identical proteins and their annotated locations for NP_001261827.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFG6
    Conserved Domains (1) summary
    cd01388
    Location:120 → 191
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFG6 M9PFG6
Q9VUD1 Q9VUD1

Gene LinkOut

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