PRLR prolactin receptor [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: PRLRprovided by CGNC
Official Full Name: prolactin receptorprovided by CGNC
Primary source: CGNC:2513
See related: Ensembl:ENSGALG00010014796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: PRL-R; PRLRb
Orthologs: all
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Genomic context

Location:: chromosome: Z

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	Z	NC_052572.1 (11159196..11350251, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	Z	NC_059536.1 (11159196..11350251, complement)

Chromosome Z - NC_052572.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dPRLR causes differences in immune responses between early and late feathering chickens after ALV-J infection.
Title: dPRLR causes differences in immune responses between early and late feathering chickens after ALV-J infection.
Study presents the causal mutation for feathering rate in turkey that causes a partial C-terminal loss of the prolactin receptor, and this truncated PRLR protein is strikingly similar to the protein encoded by the slow feathering K allele in chicken.
Title: Early and late feathering in turkey and chicken: same gene but different mutations.
A comprehensive survey for the presence or absence of ev21 and incomplete duplication (ID) of prolactin receptor (PRLR) and sperm flagellar protein 2 (SPEF2) genes across 1,994 birds from 52 chicken breeds, three commercial hybrid groups, and the Red Jungle Fowl revealed that almost all LF breeds have both ev21 and ID.
Title: Endogenous viral gene ev21 is not responsible for the expression of late feathering in chickens.
Prlr expression in the skin did not show significant difference between early- (EF) and late-feathering (LF) phenotype chicks, while Spef2 expression displayed a significant difference between EF and LF chicks, suggesting that Spef2 may be a good candidate gene for chicken feathering. Moreover, dPrlr/dSpef2, the fusion gene, was also a good candidate gene as it was expressed only in LF chicks.
Title: Identification of candidate genes for chicken early- and late-feathering.
PRLR gene was found to have a complex gene structure; PRLR Type I transcripts with exon 1G were detected to be predominantly expressed in adult kidney and small intestine; fndings suggest that like cPRL, cPRL-L is also a functional ligand of cPRLR
Title: Molecular characterization of prolactin receptor (cPRLR) gene in chickens: gene structure, tissue expression, promoter analysis, and its interaction with chicken prolactin (cPRL) and prolactin-like protein (cPRL-L).
PRLR gene polymorphisms are associated with egg production traits in chickens.
Title: Genetic effect of the prolactin receptor gene on egg production traits in chickens.
Tandem duplication in the K allele resulted in partial duplication of PRLR and SPEF2.
Title: Partial duplication of the PRLR and SPEF2 genes at the late feathering locus in chicken.
Prolactin receptor was shown to be expressed in the bursa follicles, thymus lobules, and splenic pulp at all stages of development examined.
Title: Expression patterns of the prolactin receptor gene in chicken lymphoid tissues during embryogenesis and posthatch period.
both species had very similar patterns of PRL release and expression of PRLR mRNA, and no major differences were observed between turkey or chicken embryos
Title: Ontogenesis of the expression of prolactin receptor messenger ribonucleic acid during late embryogenesis in turkeys and chickens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of signaling receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: prolactin receptor

Names: cPRLR; dPRLR-dSPEF2 fusion; equates to base 1078-1204 of D13154; prolactin receptor b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001397566.1 → NP_001384495.1 prolactin receptor precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000087

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001397567.1 → NP_001384496.1 prolactin receptor precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000087

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
NM_204854.2 → NP_990185.2 prolactin receptor precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000087

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Related

ENSGALP00010020675.1, ENSGALT00010035607.1

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

11159196..11350251 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046905231.1 → XP_046761187.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_040655394.2 → XP_040511328.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655397.2 → XP_040511331.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655399.2 → XP_040511333.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_046905229.1 → XP_046761185.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_040655403.2 → XP_040511337.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_046905230.1 → XP_046761186.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_046905223.1 → XP_046761179.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_040655408.2 → XP_040511342.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655396.2 → XP_040511330.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_046905221.1 → XP_046761177.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_040655390.2 → XP_040511324.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655407.2 → XP_040511341.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_015277236.4 → XP_015132722.2 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655406.2 → XP_040511340.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_046905224.1 → XP_046761180.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_046905233.1 → XP_046761189.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

D6MLG9, S5DMU6
XM_046905234.1 → XP_046761190.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

D6MLG9, S5DMU6
XM_046905219.1 → XP_046761175.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_046905218.1 → XP_046761174.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_046905222.1 → XP_046761178.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_046905220.1 → XP_046761176.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_040655392.2 → XP_040511326.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655395.2 → XP_040511329.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655398.2 → XP_040511332.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_046905226.1 → XP_046761182.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_046905225.1 → XP_046761181.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_046905227.1 → XP_046761183.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_025144661.3 → XP_025000429.2 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_046905228.1 → XP_046761184.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_040655391.2 → XP_040511325.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655393.2 → XP_040511327.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_046905216.1 → XP_046761172.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_040655405.2 → XP_040511339.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655410.2 → XP_040511344.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655404.2 → XP_040511338.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_046905232.1 → XP_046761188.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6
XM_040655413.2 → XP_040511347.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655411.2 → XP_040511345.1 prolactin receptor isoform X1

UniProtKB/TrEMBL

A0A8V0YID9, S5DMU6

Conserved Domains (1) summary

cd00063
Location:127 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_040655414.1 → XP_040511348.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

D6MLG9, S5DMU6

Conserved Domains (3) summary

cd00063
Location:187 → 282

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:348 → 485

GHBP; Growth hormone receptor binding

cl21522
Location:84 → 180

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

11159196..11350251 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)