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NOTCH1 notch 1 [ Gallus gallus (chicken) ]

Gene ID: 395655, updated on 3-Dec-2024

Summary

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Symbol
NOTCH1provided by CGNC
Full Name
notch 1provided by CGNC
Primary source
CGNC:49424
See related
Ensembl:ENSGALG00010028107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See NOTCH1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
36
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (8415416..8451054)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (7826632..7862049)

Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene EGF like domain multiple 7 Neighboring gene microRNA 126 Neighboring gene SEC16 homolog A, endoplasmic reticulum export factor Neighboring gene inositol polyphosphate-5-phosphatase E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Notch signaling plays a key role in cardiac cell differentiation. Chau MD, et al. Mech Dev, 2006 Aug. PMID 16843648, Free PMC Article
  2. Instability of Notch1 and Delta1 mRNAs and reduced Notch activity in vertebrate neuroepithelial cells undergoing S-phase. Cisneros E, et al. Mol Cell Neurosci, 2008 Apr. PMID 18289870
  3. Expression of active Notch1 in avian coronary development. Yang K, et al. Dev Dyn, 2009 Jan. PMID 19097050, Free PMC Article
  4. Notch mediates Wnt and BMP signals in the early separation of smooth muscle progenitors and blood/endothelial common progenitors. Shin M, et al. Development, 2009 Feb. PMID 19168675
  5. Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation. Daudet N, et al. Development, 2005 Feb. PMID 15634704

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.
    Title: Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.
  2. Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination.
    Title: Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination.
  3. Cytoplasmic NOTCH and membrane-derived beta-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis.
    Title: Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis.
  4. These results identify a novel mechanism acting downstream of muscle contraction, where YAP activates JAG2 expression in muscle fibers, which in turn regulates the pool of fetal muscle progenitors via NOTCH in a non-cell-autonomous manner.
    Title: Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis.
  5. These data identify Notch signalling as a novel modulator of Shh signalling that acts mechanistically via regulation of ciliary localisation of key components of its transduction machinery.
    Title: A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo.
  6. These results identified the apical endfoot as the central site of active Notch signaling to securely prohibit inappropriate differentiation of neural progenitors.
    Title: Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.
  7. Mib1 is a major component of the signal-sending cells required to provide Notch ligand activity for specifying neurons and glia in the spinal cord
    Title: The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.
  8. report that a novel evolutionarily conserved cis-element in the second intron of the Notch1 locus plays an important role in regulating gene expression in interneuron progenitors
    Title: A cis-element in the Notch1 locus is involved in the regulation of gene expression in interneuron progenitors.
  9. Notch Signaling Is Not Required for Growth of Intersomitic Vessels in the Chick Embryo.
    Title: Hedgehog regulates angiogenesis of intersegmental vessels through the VEGF signaling pathway.
  10. A novel Notch reporter with multiple destabilisation elements provides a faithful read-out of endogenous Notch activity.
    Title: A novel reporter of notch signalling indicates regulated and random Notch activation during vertebrate neurogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurogenic locus notch homolog protein 1
Names
Notch homolog 1, translocation-associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397796.1 → NP_001384725.1  neurogenic locus notch homolog protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000308
    UniProtKB/TrEMBL
    A0A3Q2ULK6, A0A8V1AHH1
    Related
    ENSGALP00010041850.1, ENSGALT00010068107.1
    Conserved Domains (11) summary
    smart00004
    Location:1485 → 1521
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:1931 → 2121
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:945 → 981
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1880 → 1925
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1532 → 1561
    Notch; LNR domain
    pfam03154
    Location:2086 → 2543
    Atrophin-1; Atrophin-1 family
    pfam06816
    Location:1567 → 1621
    NOD; NOTCH protein
    pfam07684
    Location:1672 → 1727
    NODP; NOTCH protein
    pfam11936
    Location:2476 → 2536
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1932 → 2025
    Ank_2; Ankyrin repeats (3 copies)
    cd21702
    Location:1719 → 1798
    JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins

  2. NM_001397797.1 → NP_001384726.1  neurogenic locus notch homolog protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000308
    UniProtKB/TrEMBL
    A0A8V1AHH1
    Conserved Domains (11) summary
    smart00004
    Location:1439 → 1475
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:1885 → 2075
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:945 → 981
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1834 → 1879
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1486 → 1515
    Notch; LNR domain
    pfam03154
    Location:2040 → 2497
    Atrophin-1; Atrophin-1 family
    pfam06816
    Location:1521 → 1575
    NOD; NOTCH protein
    pfam07684
    Location:1626 → 1681
    NODP; NOTCH protein
    pfam11936
    Location:2430 → 2490
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1886 → 1979
    Ank_2; Ankyrin repeats (3 copies)
    cd21702
    Location:1673 → 1752
    JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    8415416..8451054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046901649.1 → XP_046757605.1  neurogenic locus notch homolog protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V1AHH1
    Related
    ENSGALP00010041847.1, ENSGALT00010068104.1

  2. XM_046901650.1 → XP_046757606.1  neurogenic locus notch homolog protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V1AHH1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    7826632..7862049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046928731.1 → XP_046784687.1  neurogenic locus notch homolog protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V1AHH1

  2. XM_046928732.1 → XP_046784688.1  neurogenic locus notch homolog protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V1AHH1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001030295.1: Suppressed sequence

    Description
    NM_001030295.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version

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