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btl breathless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39564, updated on 5-Jan-2023

Summary

Official Symbol
btlprovided by FlyBase
Official Full Name
breathlessprovided by FlyBase
Primary source
FLYBASE:FBgn0285896
Locus tag
Dmel_CG32134
See related
AllianceGenome:FB:FBgn0285896
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0844/01; Btl; BTL; BTL/FGFR2; CG32134; CG6714; CT20816; D-FGFR; dev; DFGF-R1; dFGFR; Dfr-2; DFR2; Dmel\CG32134; DmHD-311; dtk2; Dtk2; fgf-r; Fgf-r; Fgfr; FGFR; FGFR1; HD-311; l(3)00208; l(3)j2E11; lambdatop; Tk2
Summary
Enables fibroblast growth factor-activated receptor activity. Involved in several processes, including animal organ development; negative regulation of cell differentiation; and open tracheal system development. Located in plasma membrane. Colocalizes with cytoneme. Is expressed in several structures, including VUM neuron; germ layer derivative; imaginal disc; presumptive embryonic/larval tracheal system; and tracheal system. Human ortholog(s) of this gene implicated in several diseases, including bone development disease (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to several human genes including FGFR1 (fibroblast growth factor receptor 1) and FGFR3 (fibroblast growth factor receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See btl in Genome Data Viewer
Location:
70D2-70D2; 3-42 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14075772..14083229)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14068872..14076329)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46067 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Formin-like Neighboring gene Peroxin 1 Neighboring gene uncharacterized protein Neighboring gene Fat body protein 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fibroblast growth factor receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables fibroblast growth factor receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branch fusion, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branching involved in open tracheal system development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in branching involved in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell type specification, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in genital disc development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in glial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lumen formation, open tracheal system IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of crystal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of plasmatocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in open tracheal system development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of positive regulation of melanization defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in primary branching, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in secondary branching, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in terminal branching, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in terminal cell fate specification, open tracheal system HMP PubMed 
involved_in terminal cell fate specification, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trachea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tracheal outgrowth, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tracheal pit formation in open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with cytoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoneme IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
breathless
Names
CG32134-PA
CG32134-PB
FGF receptor
FGFR
Fibroblast-growth-factor-receptor
btl-PA
btl-PB
devenir
fibrobast growth factor receptor
fibroblast growth factor receptor
fibroblast growth factor receptor 1
lethal (3) j2E11
no terminal cell clones-L
NP_001014583.1
NP_729956.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14075772..14083229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168577.3NP_729956.1  breathless, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729956.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09147, Q9VUC8
    Related
    FBpp0075520, FBtr0075778
    Conserved Domains (8) summary
    cd00096
    Location:258340
    Ig; Immunoglobulin domain
    smart00219
    Location:712996
    TyrKc; Tyrosine kinase, catalytic domain
    smart00408
    Location:408469
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:247336
    IG; Immunoglobulin
    smart00410
    Location:492583
    IG_like; Immunoglobulin like
    pfam07679
    Location:394479
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:507583
    Ig; Immunoglobulin domain
    cl21453
    Location:7001000
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001014583.2NP_001014583.1  breathless, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014583.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09147, Q9VUC8
    Related
    FBpp0100143, FBtr0100676
    Conserved Domains (8) summary
    cd00096
    Location:258340
    Ig; Immunoglobulin domain
    smart00219
    Location:712996
    TyrKc; Tyrosine kinase, catalytic domain
    smart00408
    Location:408469
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:247336
    IG; Immunoglobulin
    smart00410
    Location:492583
    IG_like; Immunoglobulin like
    pfam07679
    Location:394479
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:507583
    Ig; Immunoglobulin domain
    cl21453
    Location:7001000
    PKc_like; Protein Kinases, catalytic domain