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SHH sonic hedgehog [ Gallus gallus (chicken) ]

Gene ID: 395615, updated on 21-May-2019

Summary

Symbol
SHHprovided by CGNC
Full Name
sonic hedgehogprovided by CGNC
Primary source
CGNC:49404
See related
Ensembl:ENSGALG00000006379
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ShhNC
Orthologs

Genomic context

See SHH in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 2 NC_006089.5 (8166226..8175850, complement)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 2 NC_006089.4 (8112415..8122027, complement)
102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 2 NC_006089.3 (8080099..8089853, complement)

Chromosome 2 - NC_006089.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107052613 Neighboring gene RNA binding motif protein 33 Neighboring gene uncharacterized LOC107052611 Neighboring gene uncharacterized LOC112531938 Neighboring gene uncharacterized LOC112531939

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Hedgehog Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Hedgehog Signaling Pathway, organism-specific biosystemThe Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, pre...
  • Hedgehog signaling, organism-specific biosystem (from KEGG)
    Hedgehog signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Hedgehog signaling, conserved biosystem (from KEGG)
    Hedgehog signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
    Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
  • Hedgehog signaling pathway, conserved biosystem (from KEGG)
    Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
morphogen activity NAS
Non-traceable Author Statement
more info
PubMed 
patched binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate determination NAS
Non-traceable Author Statement
more info
PubMed 
cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell fate specification involved in pattern specification TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 
chondroblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
commissural neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digit morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic limb morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
floor plate formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth plate cartilage chondrocyte growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
homeostasis of number of retina cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
oligodendrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
optic cup formation involved in camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
optic nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
polarity specification of anterior/posterior axis ISS
Inferred from Sequence or Structural Similarity
more info
 
polarity specification of dorsal/ventral axis NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of gene expression TAS
Traceable Author Statement
more info
PubMed 
positive regulation of neural retina development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of apoptosis involved in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell differentiation involved in tissue homeostasis TAS
Traceable Author Statement
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
retina homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
retinal pigment epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
self proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spinal cord dorsal/ventral patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sonic hedgehog protein
Names
shh unprocessed N-terminal signaling and C-terminal autoprocessing domains
sonic hedgehog homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204821.1NP_990152.1  sonic hedgehog protein precursor

    See identical proteins and their annotated locations for NP_990152.1

    Status: PROVISIONAL

    Source sequence(s)
    L28099
    UniProtKB/Swiss-Prot
    Q91035
    Related
    ENSGALP00000010292.2, ENSGALT00000010306.6
    Conserved Domains (3) summary
    cd00081
    Location:201352
    Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
    pfam01079
    Location:190411
    Hint; Hint module
    pfam01085
    Location:42187
    HH_signal; Hedgehog amino-terminal signalling domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006089.5 Reference GRCg6a Primary Assembly

    Range
    8166226..8175850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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