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HAS2 hyaluronan synthase 2 [ Gallus gallus (chicken) ]

Gene ID: 395594, updated on 5-Sep-2025
Official Symbol
HAS2provided by CGNC
Official Full Name
hyaluronan synthase 2provided by CGNC
Primary source
CGNC:49391
See related
Ensembl:ENSGALG00010009506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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See HAS2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
5
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (136351938..136371326, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (136559987..136579429, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112531737 Neighboring gene uncharacterized LOC107052785 Neighboring gene uncharacterized LOC101751629 Neighboring gene uncharacterized LOC107052800 Neighboring gene uncharacterized LOC121109911

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Increased hyaluronan synthase-2 mRNA expression and hyaluronan accumulation with choroidal thickening: response during recovery from induced myopia. Rada JA, et al. Invest Ophthalmol Vis Sci, 2010 Dec. PMID 20574026, Free PMC Article
  2. Hyaluronan accumulates around differentiating neurons in spinal cord of chicken embryos. Mészár Z, et al. Brain Res Bull, 2008 Mar 18. PMID 18331908
  3. Hyaluronan in limb morphogenesis. Li Y, et al. Dev Biol, 2007 May 15. PMID 17362908, Free PMC Article
  4. Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family. Spicer AP, et al. J Biol Chem, 1998 Jan 23. PMID 9442026
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hyaluron accumulation is initiated by a rapid increase in choroidal expression of the HAS2 gene in response to myopic defocus.
    Title: Increased hyaluronan synthase-2 mRNA expression and hyaluronan accumulation with choroidal thickening: response during recovery from induced myopia.
  2. findings suggest a crucial role of HA during neuronal development. We propose that HA may be involved in cell migration and axonal growth in the developing spinal cord.
    Title: Hyaluronan accumulates around differentiating neurons in spinal cord of chicken embryos.
  3. Has2 is abundantly expressed by distal subridge mesodermal cells of chick limb bud and apical ectodermal ridge; Has2 overexpression in the mesoderm in vivo leads to formation of shortened and severely malformed limbs lacking one or more skeletal elements.
    Title: Hyaluronan in limb morphogenesis.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hyaluronan synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hyaluronan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
hyaluronan synthase 2
Names
HA synthase 2
hyaluronate synthase 2
hyaluronic acid synthase 2
NP_990137.2
XP_040531402.1
XP_046766285.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204806.3 → NP_990137.2  hyaluronan synthase 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000044
    UniProtKB/Swiss-Prot
    O57424
    Related
    ENSGALP00010013118.1, ENSGALT00010022704.1
    Conserved Domains (1) summary
    cd06434
    Location:84 → 361
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    136351938..136371326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040675468.2 → XP_040531402.1  hyaluronan synthase 2 isoform X1

    UniProtKB/Swiss-Prot
    O57424
    Conserved Domains (1) summary
    cd06434
    Location:84 → 361
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    136559987..136579429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910329.1 → XP_046766285.1  hyaluronan synthase 2 isoform X1

    UniProtKB/Swiss-Prot
    O57424
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O57424.2 GenPept UniProtKB/Swiss-Prot:O57424

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials