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ESR2 estrogen receptor 2 [ Gallus gallus (chicken) ]

Gene ID: 395575, updated on 5-Sep-2025
Symbol
ESR2provided by CGNC
Full Name
estrogen receptor 2provided by CGNC
Primary source
CGNC:8948
See related
Ensembl:ENSGALG00010017591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CERB
Orthologs
human mouse all
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See ESR2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (52472873..52556043)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (52451944..52534678)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC124418020 Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene A-kinase anchoring protein 5 Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Neighboring gene uncharacterized LOC121110835 Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene transfer RNA leucine (anticodon CAG)

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Oestrogen regulates the expression of cathepsin E-A-like gene through ERΒ in liver of chicken (Gallus gallus). Zheng H, et al. J Genet, 2018 Mar. PMID 29666334
  2. Changes in estrogen receptor ERalpha and ERbeta expression in chicken (Gallus domesticus) adrenal gland during short-fasting and refeeding. Błachuta M, et al. Folia Biol (Krakow), 2012. PMID 23342917
  3. Dual effects of daidzein on chicken hepatic vitellogenin II expression and estrogen receptor-mediated transactivation in vitro. Ni YD, et al. Steroids, 2010 Mar. PMID 20043933
  4. A transcriptomic comparison of theca and granulosa cells in chicken and cattle follicles reveals ESR2 as a potential regulator of CYP19A1 expression in the theca cells of chicken follicles. Jing R, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2018 Sep. PMID 29772405
  5. Aryl hydrocarbon receptor activation leads to impairment of estrogen-driven chicken vitellogenin promoter activity in LMH cells. Bussmann UA, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2013 Mar. PMID 23103859

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ESR2 is a potential regulator of CYP19A1 expression in the theca cells of chicken follicles.
    Title: A transcriptomic comparison of theca and granulosa cells in chicken and cattle follicles reveals ESR2 as a potential regulator of CYP19A1 expression in the theca cells of chicken follicles.
  2. The expression of cathepsin E-A-like was regulated by oestrogen, and the regulative effect was predominantly mediated through ER-Beta in liver of chicken.
    Title: Oestrogen regulates the expression of cathepsin E-A-like gene through ERΒ in liver of chicken (Gallus gallus).
  3. Data show that hepatocellular carcinoma LMH cells transfected with a reporter construct bearing the vitellogenin promoter is a useful model for the study of hydrocarbon receptor (AHR)-estrogen receptor (ER) interaction in liver-derived cells.
    Title: Aryl hydrocarbon receptor activation leads to impairment of estrogen-driven chicken vitellogenin promoter activity in LMH cells.
  4. Changes in ERbeta level suggest that this form of estrogen receptor plays a predominant role for estrogen action in the chicken adrenal gland during stress.
    Title: Changes in estrogen receptor ERalpha and ERbeta expression in chicken (Gallus domesticus) adrenal gland during short-fasting and refeeding.
  5. Results describe the efects of daidzein, alone or in combination with estrogen, on estrogen receptor alpha and/or beta-mediated transactivation and on chicken hepatic vitellogenin II expression.
    Title: Dual effects of daidzein on chicken hepatic vitellogenin II expression and estrogen receptor-mediated transactivation in vitro.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear estrogen receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
estrogen receptor beta
Names
ER-beta
estrogen receptor 2 (ER beta)
nuclear receptor subfamily 3 group A member 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396358.1 → NP_001383287.1  estrogen receptor beta isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/Swiss-Prot
    Q9PTU5
    UniProtKB/TrEMBL
    A0A8V0Z9A0
    Related
    ENSGALP00010025019.1, ENSGALT00010042529.1
    Conserved Domains (2) summary
    cd06949
    Location:286 → 518
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:169 → 250
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

  2. NM_204794.3 → NP_990125.2  estrogen receptor beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/Swiss-Prot
    Q9PTU5
    UniProtKB/TrEMBL
    A0A8V0Z9A0
    Conserved Domains (2) summary
    cd06949
    Location:286 → 518
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:169 → 250
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    52472873..52556043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040700579.2 → XP_040556513.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q9PTU5
    UniProtKB/TrEMBL
    A0A8V0Z9A0
    Conserved Domains (2) summary
    cd06949
    Location:286 → 518
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:169 → 250
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

  2. XM_046941376.1 → XP_046797332.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q9PTU5
    UniProtKB/TrEMBL
    A0A8V0Z9A0

  3. XM_040700580.2 → XP_040556514.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q9PTU5
    UniProtKB/TrEMBL
    A0A8V0Z9A0
    Conserved Domains (2) summary
    cd06949
    Location:286 → 518
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:169 → 250
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

  4. XM_040700581.2 → XP_040556515.1  estrogen receptor beta isoform X2

    Conserved Domains (2) summary
    cd07171
    Location:169 → 250
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    cl11397
    Location:286 → 386
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    52451944..52534678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917701.1 → XP_046773657.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q9PTU5
    UniProtKB/TrEMBL
    A0A8V0Z9A0

  2. XM_046917702.1 → XP_046773658.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q9PTU5
    UniProtKB/TrEMBL
    A0A8V0Z9A0

  3. XM_046917703.1 → XP_046773659.1  estrogen receptor beta isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9PTU5.1 GenPept UniProtKB/Swiss-Prot:Q9PTU5

Gene LinkOut

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Molecular Biology Databases
Research Materials