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GDNF glial cell derived neurotrophic factor [ Gallus gallus (chicken) ]

Gene ID: 395569, updated on 3-Dec-2024
Symbol
GDNFprovided by CGNC
Full Name
glial cell derived neurotrophic factorprovided by CGNC
Primary source
CGNC:2717
See related
Ensembl:ENSGALG00010012878
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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See GDNF in Genome Data Viewer
Location:
chromosome: Z
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (12276028..12296052, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (12276028..12296052, complement)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene nucleoporin 155 Neighboring gene WD repeat domain 70 Neighboring gene uncharacterized LOC121108608 Neighboring gene uncharacterized LOC121108609 Neighboring gene uncharacterized LOC121108610

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Gdnf is mitogenic, neurotrophic, and chemoattractive to enteric neural crest cells in the embryonic colon. Mwizerwa O, et al. Dev Dyn, 2011 Jun. PMID 21465624, Free PMC Article
  2. Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway. Pérez-García MJ, et al. J Biol Chem, 2004 Feb 13. PMID 14630929
  3. Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo. Homma S, et al. Dev Biol, 2000 Jan 1. PMID 10625540
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An important role for Gdnf signaling in colonic enteric nervous system formation and emphasize the critical balance between proliferation and differentiation in the developing enteric nervous system.
    Title: Gdnf is mitogenic, neurotrophic, and chemoattractive to enteric neural crest cells in the embryonic colon.
  2. Glial cell line-derived neurotrophic factor has a role in increasing intracellular calcium concentration
    Title: Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glial cell-derived neurotrophic factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peripheral nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
glial cell line-derived neurotrophic factor
Names
glial cell line-derived neurotrophic factor long form

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    12276028..12296052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004937198.5 → XP_004937255.1  glial cell line-derived neurotrophic factor isoform X2

    UniProtKB/TrEMBL
    Q9IAM2
    Conserved Domains (1) summary
    cd19380
    Location:89 → 184
    TGF_beta_GDNF; transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins

  2. XM_425018.8 → XP_425018.4  glial cell line-derived neurotrophic factor isoform X1

    UniProtKB/TrEMBL
    A0A8V0YHD0, Q9IAM3
    Related
    ENSGALP00010017943.1, ENSGALT00010030899.1
    Conserved Domains (1) summary
    cd19380
    Location:122 → 217
    TGF_beta_GDNF; transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins

  3. XM_046905816.1 → XP_046761772.1  glial cell line-derived neurotrophic factor isoform X1

    UniProtKB/TrEMBL
    A0A8V0YHD0, Q9IAM3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12276028..12296052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046935501.1 → XP_046791457.1  glial cell line-derived neurotrophic factor isoform X2

    UniProtKB/TrEMBL
    Q9IAM2

  2. XM_046935499.1 → XP_046791455.1  glial cell line-derived neurotrophic factor isoform X1

    UniProtKB/TrEMBL
    A0A8V0YHD0, Q9IAM3

  3. XM_046935500.1 → XP_046791456.1  glial cell line-derived neurotrophic factor isoform X1

    UniProtKB/TrEMBL
    A0A8V0YHD0, Q9IAM3
Nucleotide Protein
Heading Accession and Version

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