FOXA2 forkhead box A2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: FOXA2provided by CGNC
Full Name: forkhead box A2provided by CGNC
Primary source: CGNC:49366
See related: Ensembl:ENSGALG00010018076
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: HNF-3BETA
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (3543600..3547310)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (3467218..3470924)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nato3 induces ectopic Foxa2-positive cells and indirectly downregulates Nkx2.2 expression.
Title: Nato3 plays an integral role in dorsoventral patterning of the spinal cord by segregating floor plate/p3 fates via Nkx2.2 suppression and Foxa2 maintenance.
The transcription factor FOXA2 can execute the full midbrain and spinal cord floor plate program via HH-independent and dependent mechanisms.
Title: A novel role for FOXA2 and SHH in organizing midbrain signaling centers.
Data suggest that Nato3 is a direct target of Foxa2, a transcription activator and effector of Sonic hedgehog, the hallmark regulator of neural tube floor plate induction and spinal cord development.
Title: Foxa2 regulates the expression of Nato3 in the floor plate by a novel evolutionarily conserved promoter.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transcription factor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: hepatocyte nuclear factor 3-beta

Names: hepatocyte nuclear factor-3beta; transcription factor Foxa2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204770.2 → NP_990101.2 hepatocyte nuclear factor 3-beta

Status: VALIDATED

Source sequence(s)

JAENSK010000060

UniProtKB/TrEMBL

A0A1D5NX62, Q9PWP8

Related

ENSGALP00010026009.1, ENSGALT00010043712.1

Conserved Domains (2) summary

smart00339
Location:151 → 239

FH; FORKHEAD

pfam08430
Location:17 → 150

Forkhead_N; Forkhead N-terminal region