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EBF1 EBF transcription factor 1 [ Gallus gallus (chicken) ]

Gene ID: 395512, updated on 13-Apr-2026
Official Symbol
EBF1provided by CGNC
Official Full Name
EBF transcription factor 1provided by CGNC
Primary source
CGNC:49357
See related
Ensembl:ENSGALG00010012921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
EBF; cEBF1
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See EBF1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (10287788..10551209)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (10290345..10553851)

Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene ubiquitin like domain containing CTD phosphatase 1 Neighboring gene ring finger protein 145 Neighboring gene uncharacterized LOC101749832 Neighboring gene clathrin interactor 1 Neighboring gene LSM11, U7 small nuclear RNA associated

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Expression and function of Ebf1 gene during chondrogenesis in chick embryo limb buds. El-Magd MA, et al. Gene, 2021 Nov 30. PMID 34384862
  2. Regulation of chick early B-cell factor-1 gene expression in feather development. El-Magd MA, et al. Acta Histochem, 2014 May. PMID 24365066
  3. Shh regulates chick Ebf1 gene expression in somite development. El-Magd MA, et al. Gene, 2015 Jan 1. PMID 25455103
  4. EBF1 acts as a powerful repressor of Blimp-1 gene expression in immature B cells. Kikuchi H, et al. Biochem Biophys Res Commun, 2012 Jun 15. PMID 22634309
  5. Ebf gene function is required for coupling neuronal differentiation and cell cycle exit. Garcia-Dominguez M, et al. Development, 2003 Dec. PMID 14573522

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression and function of Ebf1 gene during chondrogenesis in chick embryo limb buds.
    Title: Expression and function of Ebf1 gene during chondrogenesis in chick embryo limb buds.
  2. early B-cell factor-1 expression in the feather bud is under the control of Sonic Hedgehog and Bmp4 signals and that expression may play a role in the normal development of feathers
    Title: Regulation of chick early B-cell factor-1 gene expression in feather development.
  3. cEbf1 gene is considered as a medial sclerotome marker, downstream to and regulated by the notochord derived Shh, which may be functionally involved in somitogenesis
    Title: Shh regulates chick Ebf1 gene expression in somite development.
  4. Ectopic expression of retinoic acid (RA) led to up-regulation of cEbf2, 3 but did not change cEbf1 expression in somites. Expectedly, inhibition of RA by disulfiram resulted in downregulation of cEbf2, 3, but did not change cEbf1 expression in somites. The same RA gain and loss of function experiments did not change cEbf1-3 expression in pharyngeal arches.
    Title: The effect of RA on the chick Ebf1-3 genes expression in somites and pharyngeal arches.
  5. GCN5 binds to the 5'-flanking region of the chicken PRKCQ gene and acetylates histone H3, and EBF1 binds to the 5'-flanking region of the gene surrounding putative EBF1 binding motifs.
    Title: Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells.
  6. This is the first report on a novel EBF1 function in immature B cells as a powerful repressor of Blimp-1 gene expression.
    Title: EBF1 acts as a powerful repressor of Blimp-1 gene expression in immature B cells.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
transcription factor COE1
Names
early B-cell factor 1 protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397656.1 → NP_001384585.1  transcription factor COE1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000256
    UniProtKB/TrEMBL
    A0A8V0YHL9, Q9I9C6
    Related
    ENSGALP00010018034.1, ENSGALT00010031026.1
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  2. NM_001397657.1 → NP_001384586.1  transcription factor COE1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000256
    UniProtKB/TrEMBL
    Q9I9C6
    Conserved Domains (3) summary
    cd01175
    Location:255 → 339
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:340 → 383
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  3. NM_001397658.1 → NP_001384587.1  transcription factor COE1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000256
    UniProtKB/TrEMBL
    Q9I9C6
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  4. NM_001397659.1 → NP_001384588.1  transcription factor COE1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000256
    UniProtKB/TrEMBL
    A0A8V0YHL3
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  5. NM_204752.3 → NP_990083.2  transcription factor COE1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000256
    UniProtKB/TrEMBL
    Q9I9C6
    Conserved Domains (3) summary
    cd01175
    Location:262 → 346
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:347 → 390
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10287788..10551209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015293734.4 → XP_015149220.1  transcription factor COE1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YHL3, F1N9Q3
    Related
    ENSGALP00010018031.1, ENSGALT00010031020.1
    Conserved Domains (3) summary
    cd01175
    Location:263 → 347
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:348 → 391
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  2. XM_015293735.4 → XP_015149221.1  transcription factor COE1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YHL3
    Related
    ENSGALP00010018029.1, ENSGALT00010031018.1
    Conserved Domains (3) summary
    cd01175
    Location:262 → 346
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:347 → 390
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  3. XM_015293736.4 → XP_015149222.1  transcription factor COE1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YHL3
    Conserved Domains (3) summary
    cd01175
    Location:255 → 339
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:340 → 383
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  4. XM_015293740.4 → XP_015149226.1  transcription factor COE1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YHL3
    Conserved Domains (3) summary
    cd11606
    Location:16 → 217
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
    cd01175
    Location:233 → 317
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:318 → 361
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  5. XM_015293741.4 → XP_015149227.1  transcription factor COE1 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YHL3
    Conserved Domains (3) summary
    cd11606
    Location:16 → 217
    COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
    cd01175
    Location:232 → 316
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16423
    Location:317 → 360
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10290345..10553851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926826.1 → XP_046782782.1  transcription factor COE1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YHL3, F1N9Q3

  2. XM_046926827.1 → XP_046782783.1  transcription factor COE1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YHL3

  3. XM_046926828.1 → XP_046782784.1  transcription factor COE1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YHL3

  4. XM_046926829.1 → XP_046782785.1  transcription factor COE1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YHL3

  5. XM_046926830.1 → XP_046782786.1  transcription factor COE1 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YHL3
Nucleotide Protein Strain
Heading Accession and Version

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