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DDX4 DEAD-box helicase 4 [ Gallus gallus (chicken) ]

Gene ID: 395447, updated on 13-Apr-2026
Symbol
DDX4provided by CGNC
Full Name
DEAD-box helicase 4provided by CGNC
Primary source
CGNC:10908
See related
Ensembl:ENSGALG00010014189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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See DDX4 in Genome Data Viewer
Location:
chromosome: Z
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (17471887..17503681)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (17471887..17503681)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene Ski2 like RNA helicase 2 Neighboring gene phospholipid phosphatase 1 Neighboring gene solute carrier family 38 member 9 Neighboring gene interleukin 31 receptor A Neighboring gene uncharacterized LOC124417516 Neighboring gene interleukin 6 signal transducer

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Is Vasa such a highly specific marker for primordial germ cells? A comparison of VASA and HSP90 proteins expression in young chicken embryos. Lejong M, et al. Morphologie, 2020 Mar. PMID 32057659
  2. Knockdown of DEAD-box helicase 4 (DDX4) decreases the number of germ cells in male and female chicken embryonic gonads. Aduma N, et al. Reprod Fertil Dev, 2019 Apr. PMID 30554591
  3. Ectopic expression of Cvh (Chicken Vasa homologue) mediates the reprogramming of chicken embryonic stem cells to a germ cell fate. Lavial F, et al. Dev Biol, 2009 Jun 1. PMID 19324033
  4. Germ cell-specific expression of GFP gene induced by chicken vasa homologue (Cvh) promoter in early chicken embryos. Minematsu T, et al. Mol Reprod Dev, 2008 Oct. PMID 18324671
  5. Temporal and spatial differential expression of chicken germline-specific proteins cDAZL, CDH and CVH during gametogenesis. Kito G, et al. J Reprod Dev, 2010 Jun. PMID 20332590

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Is Vasa such a highly specific marker for primordial germ cells? A comparison of VASA and HSP90 proteins expression in young chicken embryos.
    Title: Is Vasa such a highly specific marker for primordial germ cells? A comparison of VASA and HSP90 proteins expression in young chicken embryos.
  2. Male and female gonads of DDX4-knockdown embryos contained a decreased number of primordial germ cells, indicating that DDX4 is essential to maintain a normal level of these cells in chicken embryos of both sexes.
    Title: Knockdown of DEAD-box helicase 4 (DDX4) decreases the number of germ cells in male and female chicken embryonic gonads.
  3. cDAZL, CDH and CVH are expressed in chicken germ cells, but their patterns of expression are temporally and spatially distinct
    Title: Temporal and spatial differential expression of chicken germline-specific proteins cDAZL, CDH and CVH during gametogenesis.
  4. Thus, our results demonstrate that Vasa can drive ES cell differentiation towards the germ cell lineage, both in vitro and in vivo
    Title: Ectopic expression of Cvh (Chicken Vasa homologue) mediates the reprogramming of chicken embryonic stem cells to a germ cell fate.
  5. Cvh promoter provide the basis for for visualization, purification and genetical modification of germ cells, and might further contribute to our understanding of the development, proliferation, migration and differentiation of germ cells in the chicken
    Title: Germ cell-specific expression of GFP gene induced by chicken vasa homologue (Cvh) promoter in early chicken embryos.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in gamete generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in P granule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
probable ATP-dependent RNA helicase DDX4
Names
Cvh
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
NP_990039.2
XP_040511298.1
XP_046790668.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204708.3 → NP_990039.2  probable ATP-dependent RNA helicase DDX4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000089
    UniProtKB/TrEMBL
    A0A8V0YN56, F1N991
    Related
    ENSGALP00010020084.1, ENSGALT00010034190.1
    Conserved Domains (2) summary
    cd18787
    Location:463 → 592
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cd18052
    Location:194 → 457
    DEADc_DDX4; DEAD-box helicase domain of DEAD box protein 4

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    17471887..17503681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040655364.2 → XP_040511298.1  probable ATP-dependent RNA helicase DDX4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YN56, F1N991
    Related
    ENSGALP00010020072.1, ENSGALT00010034167.1
    Conserved Domains (2) summary
    cd18787
    Location:463 → 592
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cd18052
    Location:194 → 457
    DEADc_DDX4; DEAD-box helicase domain of DEAD box protein 4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    17471887..17503681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934712.1 → XP_046790668.1  probable ATP-dependent RNA helicase DDX4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YN56, F1N991
Nucleotide Protein Strain
Heading Accession and Version

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