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NPAS2 neuronal PAS domain protein 2 [ Gallus gallus (chicken) ]

Gene ID: 395433, updated on 14-Feb-2019

Summary

Symbol
NPAS2provided by CGNC
Full Name
neuronal PAS domain protein 2provided by CGNC
Primary source
CGNC:12580
See related
Ensembl:ENSGALG00000016774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
MOP4
Summary
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Feb 2014]
Orthologs

Genomic context

See NPAS2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
24
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 1 NC_006088.5 (134570730..134668759)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 1 NC_006088.4 (133321944..133431024)
102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 1 NC_006088.3 (132673794..132721795)

Chromosome 1 - NC_006088.5Genomic Context describing neighboring genes Neighboring gene phosducin like 3 Neighboring gene uncharacterized LOC107051968 Neighboring gene transcription initiation factor TFIID subunit 4-like Neighboring gene ribosomal protein L31 Neighboring gene TBC1 domain family member 8 Neighboring gene transfer RNA proline (anticodon AGG)

Genomic regions, transcripts, and products

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
response to redox state ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuronal PAS domain-containing protein 2
Names
bHLH-PAS clock protein
bHLH-PAS transcription factor MOP4
member of PAS protein 4
neuronal PAS2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030542.2NP_001025713.1  neuronal PAS domain-containing protein 2

    See identical proteins and their annotated locations for NP_001025713.1

    Status: VALIDATED

    Source sequence(s)
    AADN05000806, AF396828
    UniProtKB/Swiss-Prot
    Q5ZQU2
    Related
    ENSGALP00000035797.2, ENSGALT00000036585.4
    Conserved Domains (6) summary
    smart00091
    Location:84145
    PAS; PAS domain
    cd00083
    Location:761
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:250348
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:84177
    PAS; PAS fold
    pfam07223
    Location:421678
    DUF1421; Protein of unknown function (DUF1421)
    pfam14598
    Location:249352
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006088.5 Reference GRCg6a Primary Assembly

    Range
    134570730..134668759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015277679.2XP_015133165.1  neuronal PAS domain-containing protein 2 isoform X3

    Conserved Domains (6) summary
    smart00091
    Location:183244
    PAS; PAS domain
    cd00083
    Location:106160
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:349447
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:183256
    PAS; PAS fold
    pfam07223
    Location:520777
    DUF1421; Protein of unknown function (DUF1421)
    pfam14598
    Location:348451
    PAS_11; PAS domain
  2. XM_015277677.2XP_015133163.1  neuronal PAS domain-containing protein 2 isoform X1

    Conserved Domains (6) summary
    smart00091
    Location:183244
    PAS; PAS domain
    cd00083
    Location:106160
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:349447
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:183256
    PAS; PAS fold
    pfam07223
    Location:520777
    DUF1421; Protein of unknown function (DUF1421)
    pfam14598
    Location:348451
    PAS_11; PAS domain
  3. XM_015277680.2XP_015133166.1  neuronal PAS domain-containing protein 2 isoform X4

    Conserved Domains (5) summary
    smart00091
    Location:183244
    PAS; PAS domain
    cd00083
    Location:106160
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:349447
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:183256
    PAS; PAS fold
    pfam14598
    Location:348451
    PAS_11; PAS domain
  4. XM_015277681.2XP_015133167.1  neuronal PAS domain-containing protein 2 isoform X5

    Conserved Domains (6) summary
    smart00091
    Location:183244
    PAS; PAS domain
    cd00083
    Location:106160
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:311409
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:183292
    PAS; PAS fold
    pfam07223
    Location:482739
    DUF1421; Protein of unknown function (DUF1421)
    pfam14598
    Location:310413
    PAS_11; PAS domain
  5. XM_015277682.2XP_015133168.1  neuronal PAS domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    E1BZV0
    Conserved Domains (6) summary
    smart00091
    Location:84145
    PAS; PAS domain
    cd00083
    Location:761
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:250348
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:84157
    PAS; PAS fold
    pfam07223
    Location:421678
    DUF1421; Protein of unknown function (DUF1421)
    pfam14598
    Location:249352
    PAS_11; PAS domain
  6. XM_015277683.2XP_015133169.1  neuronal PAS domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    E1BZV0
    Conserved Domains (6) summary
    smart00091
    Location:84145
    PAS; PAS domain
    cd00083
    Location:761
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:250348
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:84157
    PAS; PAS fold
    pfam07223
    Location:421678
    DUF1421; Protein of unknown function (DUF1421)
    pfam14598
    Location:249352
    PAS_11; PAS domain
  7. XM_015277678.2XP_015133164.1  neuronal PAS domain-containing protein 2 isoform X2

    Conserved Domains (6) summary
    smart00091
    Location:128189
    PAS; PAS domain
    cd00083
    Location:51105
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:294392
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:128201
    PAS; PAS fold
    pfam07223
    Location:465722
    DUF1421; Protein of unknown function (DUF1421)
    pfam14598
    Location:293396
    PAS_11; PAS domain
  8. XM_015277684.1XP_015133170.1  neuronal PAS domain-containing protein 2 isoform X7

    Conserved Domains (3) summary
    cd00130
    Location:179277
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07223
    Location:350607
    DUF1421; Protein of unknown function (DUF1421)
    pfam14598
    Location:178281
    PAS_11; PAS domain
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