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ATM ATM serine/threonine kinase [ Gallus gallus (chicken) ]

Gene ID: 395401, updated on 14-Jan-2019

Summary

Symbol
ATMprovided by CGNC
Full Name
ATM serine/threonine kinaseprovided by CGNC
Primary source
CGNC:12888
See related
Ensembl:ENSGALG00000017159
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs

Genomic context

See ATM in Genome Data Viewer
Location:
chromosome: 1
Exon count:
63
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 1 NC_006088.5 (181590958..181650696, complement)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 1 NC_006088.4 (180285849..180345559, complement)

Chromosome 1 - NC_006088.5Genomic Context describing neighboring genes Neighboring gene exophilin 5 Neighboring gene KDEL motif containing 2 Neighboring gene nuclear protein, coactivator of histone transcription Neighboring gene acetyl-CoA acetyltransferase 1

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem (from KEGG)
    BRCA1-associated genome surveillance complex (BASC), organism-specific biosystemStructural complex; Genetic information processing; Repair system
  • BRCA1-associated genome surveillance complex (BASC), conserved biosystem (from KEGG)
    BRCA1-associated genome surveillance complex (BASC), conserved biosystemStructural complex; Genetic information processing; Repair system
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, organism-specific biosystem (from WikiPathways)
    Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • DNA damage-induced cell cycle checkpoints, organism-specific biosystem (from KEGG)
    DNA damage-induced cell cycle checkpoints, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • DNA damage-induced cell cycle checkpoints, conserved biosystem (from KEGG)
    DNA damage-induced cell cycle checkpoints, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
    G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
  • Homologous recombination, organism-specific biosystem (from KEGG)
    Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
  • Homologous recombination, organism-specific biosystem (from WikiPathways)
    Homologous recombination, organism-specific biosystemHomologous recombination, also known as general recombination, is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical strands of DNA. Source:...
  • Homologous recombination, conserved biosystem (from KEGG)
    Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

General gene information

Markers

Homology

General protein information

Preferred Names
serine-protein kinase ATM
Names
ATM (ataxia telangiectasia mutated)
ataxia telangiectasia mutated (includes complementation groups A, C and D)
NP_001155872.1
XP_015133057.1
XP_015133060.1
XP_025010358.1
XP_025010375.1
XP_025010397.1
XP_025010458.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162400.1NP_001155872.1  serine-protein kinase ATM

    Status: PROVISIONAL

    Source sequence(s)
    AADN05000588
    UniProtKB/TrEMBL
    E1C0Q6
    Related
    ENSGALP00000027660.6, ENSGALT00000027713.7
    Conserved Domains (4) summary
    cd05171
    Location:26772956
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:20902483
    FAT; FAT domain
    pfam02260
    Location:30203049
    FATC; FATC domain
    pfam11640
    Location:10164
    TAN; Telomere-length maintenance and DNA damage repair

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006088.5 Reference GRCg6a Primary Assembly

    Range
    181590958..181650696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015277574.2XP_015133060.1  serine-protein kinase ATM isoform X2

    Conserved Domains (4) summary
    cd05171
    Location:26972976
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:21042503
    FAT; FAT domain
    pfam02260
    Location:30393068
    FATC; FATC domain
    pfam11640
    Location:10164
    TAN; Telomere-length maintenance and DNA damage repair
  2. XM_015277571.2XP_015133057.1  serine-protein kinase ATM isoform X1

    Conserved Domains (4) summary
    cd05171
    Location:26972976
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:21042503
    FAT; FAT domain
    pfam02260
    Location:30403069
    FATC; FATC domain
    pfam11640
    Location:10164
    TAN; Telomere-length maintenance and DNA damage repair
  3. XM_025154590.1XP_025010358.1  serine-protein kinase ATM isoform X3

    Conserved Domains (2) summary
    cd05171
    Location:21312410
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    cl26692
    Location:14422503
    FRB_dom; FKBP12-rapamycin binding domain
  4. XM_025154607.1XP_025010375.1  serine-protein kinase ATM isoform X4

    Conserved Domains (1) summary
    pfam11640
    Location:8164
    TAN; Telomere-length maintenance and DNA damage repair
  5. XM_025154629.1XP_025010397.1  serine-protein kinase ATM isoform X5

    Conserved Domains (1) summary
    pfam11640
    Location:8164
    TAN; Telomere-length maintenance and DNA damage repair
  6. XM_025154690.1XP_025010458.1  serine-protein kinase ATM isoform X6

    Conserved Domains (1) summary
    pfam11640
    Location:8164
    TAN; Telomere-length maintenance and DNA damage repair

RNA

  1. XR_003077418.1 RNA Sequence

  2. XR_003077431.1 RNA Sequence

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