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PRKDC protein kinase, DNA-activated, catalytic polypeptide [ Gallus gallus (chicken) ]

Gene ID: 395376, updated on 12-Aug-2018

Summary

Official Symbol
PRKDCprovided by CGNC
Official Full Name
protein kinase, DNA-activated, catalytic polypeptideprovided by CGNC
Primary source
CGNC:49288
See related
Ensembl:ENSGALG00000042469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
dnapkcs; DNA-PKCS
Orthologs

Genomic context

See PRKDC in Genome Data Viewer
Location:
chromosome: 2
Exon count:
86
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 2 NC_006089.5 (107917056..108001222, complement)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 2 NC_006089.4 (108253971..108338281, complement)

Chromosome 2 - NC_006089.5Genomic Context describing neighboring genes Neighboring gene KIAA0146 Neighboring gene uncharacterized LOC112531851 Neighboring gene CCAAT enhancer binding protein delta Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene minichromosome maintenance complex component 4

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, organism-specific biosystem (from WikiPathways)
    Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • DNA-PK complex, organism-specific biosystem (from KEGG)
    DNA-PK complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
  • DNA-PK complex, conserved biosystem (from KEGG)
    DNA-PK complex, conserved biosystemStructural complex; Genetic information processing; Repair system
  • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
    FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
  • Non-homologous end-joining, organism-specific biosystem (from KEGG)
    Non-homologous end-joining, organism-specific biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...
  • Non-homologous end-joining, conserved biosystem (from KEGG)
    Non-homologous end-joining, conserved biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
kinase activity TAS
Traceable Author Statement
more info
 
protein binding TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair via homologous recombination TAS
Traceable Author Statement
more info
 
double-strand break repair via nonhomologous end joining TAS
Traceable Author Statement
more info
 
immunoglobulin V(D)J recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction involved in mitotic G1 DNA damage checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nonhomologous end joining complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DNA-dependent protein kinase catalytic subunit
Names
DNA-PK catalytic subunit
NP_989989.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204658.2NP_989989.2  DNA-dependent protein kinase catalytic subunit

    See identical proteins and their annotated locations for NP_989989.2

    Status: VALIDATED

    Source sequence(s)
    AADN04000228, AB016240
    UniProtKB/Swiss-Prot
    Q8QGX4
    Related
    ENSGALP00000051478.1, ENSGALT00000074679.1
    Conserved Domains (4) summary
    cd05172
    Location:37254021
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:30293476
    FAT; FAT domain
    pfam02260
    Location:41044134
    FATC; FATC domain
    pfam08163
    Location:18142202
    NUC194; NUC194 domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006089.5 Reference GRCg6a Primary Assembly

    Range
    107917056..108001222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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