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CBX3 chromobox 3 [ Gallus gallus (chicken) ]

Gene ID: 395355, updated on 13-Apr-2026
Symbol
CBX3provided by CGNC
Full Name
chromobox 3provided by CGNC
Primary source
CGNC:8386
See related
Ensembl:ENSGALG00010001861
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CBX3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (32098309..32112175)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (32150199..32164040)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109870 Neighboring gene uncharacterized LOC101752322 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 Neighboring gene sorting nexin 10 Neighboring gene uncharacterized LOC121110065 Neighboring gene uncharacterized LOC121110066

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Chromobox protein homolog 3 is essential for stem cell differentiation to smooth muscles in vitro and in embryonic arteriogenesis. Xiao Q, et al. Arterioscler Thromb Vasc Biol, 2011 Aug. PMID 21659642
  2. Chicken chromobox proteins: cDNA cloning of CHCB1, -2, -3 and their relation to W-heterochromatin. Yamaguchi K, et al. Exp Cell Res, 1998 Jul 10. PMID 9665828
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. misexpression of Cbx3 within neural crest cells resulted in the death embryos at early stages because of the maldevelopment of branchial arch arteries
    Title: Chromobox protein homolog 3 is essential for stem cell differentiation to smooth muscles in vitro and in embryonic arteriogenesis.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of pericentric heterochromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
chromobox protein homolog 3
Names
chromobox homolog 3 (HP1 gamma homolog, Drosophila)
chromobox protein (CHCB2)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204643.2 → NP_989974.1  chromobox protein homolog 3

    See identical proteins and their annotated locations for NP_989974.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000037
    UniProtKB/TrEMBL
    A0A1D5PPQ0, A0A8V0XDL0, O93481
    Related
    ENSGALP00010002523.1, ENSGALT00010004226.1
    Conserved Domains (2) summary
    cd18652
    Location:19 → 68
    CD_HP1gamma_Cbx3; chromodomain of heterochromatin protein 1 homolog gamma
    cd18656
    Location:107 → 164
    CSD_HP1gamma_Cbx3; chromo shadow domain of heterochromatin protein 1 gamma homolog gamma

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    32098309..32112175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040675354.2 → XP_040531288.1  chromobox protein homolog 3 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PEX8, A0A8V0XDL0
    Conserved Domains (2) summary
    cd18652
    Location:29 → 78
    CD_HP1gamma_Cbx3; chromodomain of heterochromatin protein 1 homolog gamma
    cd18656
    Location:117 → 174
    CSD_HP1gamma_Cbx3; chromo shadow domain of heterochromatin protein 1 gamma homolog gamma

  2. XM_015281285.4 → XP_015136771.1  chromobox protein homolog 3 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PPQ0, A0A8V0XDL0, O93481
    Conserved Domains (2) summary
    cd18652
    Location:19 → 68
    CD_HP1gamma_Cbx3; chromodomain of heterochromatin protein 1 homolog gamma
    cd18656
    Location:107 → 164
    CSD_HP1gamma_Cbx3; chromo shadow domain of heterochromatin protein 1 gamma homolog gamma

  3. XM_015281284.4 → XP_015136770.1  chromobox protein homolog 3 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PEX8, A0A8V0XDL0
    Related
    ENSGALP00010002526.1, ENSGALT00010004229.1
    Conserved Domains (2) summary
    cd18652
    Location:29 → 78
    CD_HP1gamma_Cbx3; chromodomain of heterochromatin protein 1 homolog gamma
    cd18656
    Location:117 → 174
    CSD_HP1gamma_Cbx3; chromo shadow domain of heterochromatin protein 1 gamma homolog gamma

  4. XM_040675372.2 → XP_040531306.1  chromobox protein homolog 3 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PPQ0, A0A8V0XDL0, O93481
    Conserved Domains (2) summary
    cd18652
    Location:19 → 68
    CD_HP1gamma_Cbx3; chromodomain of heterochromatin protein 1 homolog gamma
    cd18656
    Location:107 → 164
    CSD_HP1gamma_Cbx3; chromo shadow domain of heterochromatin protein 1 gamma homolog gamma

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    32150199..32164040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910299.1 → XP_046766255.1  chromobox protein homolog 3 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PEX8, A0A8V0XDL0
    Conserved Domains (2) summary
    cd18652
    Location:29 → 78
    CD_HP1gamma_Cbx3; chromodomain of heterochromatin protein 1 homolog gamma
    cd18656
    Location:117 → 174
    CSD_HP1gamma_Cbx3; chromo shadow domain of heterochromatin protein 1 gamma homolog gamma

  2. XM_046910300.1 → XP_046766256.1  chromobox protein homolog 3 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PPQ0, A0A8V0XDL0, O93481

  3. XM_046910298.1 → XP_046766254.1  chromobox protein homolog 3 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PEX8, A0A8V0XDL0
    Conserved Domains (2) summary
    cd18652
    Location:29 → 78
    CD_HP1gamma_Cbx3; chromodomain of heterochromatin protein 1 homolog gamma
    cd18656
    Location:117 → 174
    CSD_HP1gamma_Cbx3; chromo shadow domain of heterochromatin protein 1 gamma homolog gamma

  4. XM_046910301.1 → XP_046766257.1  chromobox protein homolog 3 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PPQ0, A0A8V0XDL0, O93481
Nucleotide Protein
Heading Accession and Version

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