IL6 interleukin 6 [Gallus gallus (chicken)] - Gene

Summary

Symbol: IL6provided by CGNC
Full Name: interleukin 6provided by CGNC
Primary source: CGNC:8294
See related: Ensembl:ENSGALG00010001941
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: IL-6; CHIL-6; interleukin-6
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (30771353..30774770)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (30804079..30807495)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of the current study indicate that thermal manipulation enhanced the heat tolerance through improving the protective immunological response to heat stress by enhancing the expression of interleukin-6 (IL-6) and modulating the expression of genes important in its induction pathways.
Title: Effects of pre-hatch thermal manipulation and post-hatch acute heat stress on the mRNA expression of interleukin-6 and genes involved in its induction pathways in 2 broiler chicken breeds.
RNA sequencing results revealed that the chicken IL6 was more downregulated in the intestinal mucosal layer of Necrotic enteritis induced chicken lines that are resistant and sensitive to avian leukosis and Marek's disease.
Title: Expression analysis of cytosolic DNA-sensing pathway genes in the intestinal mucosal layer of necrotic enteritis-induced chicken.
Avian leukosis virus subgroup J induces VEGF expression via NF-kappaB/PI3K-dependent IL-6 production to promoter tumorigenesis.
Title: Avian leukosis virus subgroup J induces VEGF expression via NF-κB/PI3K-dependent IL-6 production.
The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3. However, the mRNA expression levels of IL-4, IL-12beta, and IL-1beta were decreased in the experiment.
Title: Arsenic Trioxide Attenuates NF-κB and Cytokine mRNA Levels in the Livers of Cocks.
The effects of daily corticosterone injections on acute phase proteins (APP), IL-6, and HSP70 are reported; APP and HSP70 may be of value as indicators of stress in poultry.
Title: Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone.
Chicken IL-6 is a heat-shock gene
Title: Chicken IL-6 is a heat-shock gene.
zearalenone affects IL-2, IL-6, and IFN-gamma mRNA levels in the splenic lymphocytes of chickens
Title: Effects of zearalenone on IL-2, IL-6, and IFN-γ mRNA levels in the splenic lymphocytes of chickens.
Data show that IL-10, IFN-gamma and TNF-alpha contents in the cecal tonsil were significantly decreased in the 30, 45 and 60 mg/kg groups, while IL-6 content in the cecal tonsil was only decreased in 60 mg/kg at 14 and 28 days of age.
Title: Changes of IgA+ cells and cytokines in the cecal tonsil of broilers fed on diets supplemented with vanadium.
Nampt/visfatin/PBEF affects expression of myogenic regulatory factors and is regulated by interleukin-6 in chicken skeletal muscle cells
Title: Nampt/visfatin/PBEF affects expression of myogenic regulatory factors and is regulated by interleukin-6 in chicken skeletal muscle cells.
The expression of interleukin(IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha in amyoidosis arthropathy in chickens was studied.
Title: The role of chicken IL-1beta, IL-6 and TNF-alpha in the occurrence of amyloid arthropathy.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables interleukin-6 receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper 17 cell lineage commitment	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-6

Names: interleukin 6 (interferon, beta 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.