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NFIL3 nuclear factor, interleukin 3 regulated [ Gallus gallus (chicken) ]

Gene ID: 395326, updated on 19-Mar-2019

Summary

Symbol
NFIL3provided by CGNC
Full Name
nuclear factor, interleukin 3 regulatedprovided by CGNC
Primary source
CGNC:11317
See related
Ensembl:ENSGALG00000015209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Summary
The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]
Orthologs

Genomic context

See NFIL3 in Genome Data Viewer
Location:
chromosome: Z
Exon count:
3
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) Z NC_006127.5 (44356108..44370013, complement)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) Z NC_006127.4 (44344648..44358564, complement)
102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) Z NC_006127.3 (44205822..44207406, complement)

Chromosome Z - NC_006127.5Genomic Context describing neighboring genes Neighboring gene tubulin polymerization promoting protein family member 2 Neighboring gene AU RNA binding methylglutaconyl-CoA hydratase Neighboring gene receptor tyrosine kinase like orphan receptor 2 Neighboring gene serine palmitoyltransferase long chain base subunit 1

Genomic regions, transcripts, and products

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear factor interleukin-3-regulated protein
Names
E4 promoter-binding protein 4
bZIP protein E4BP4
cE4BP4 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204618.2NP_989949.1  nuclear factor interleukin-3-regulated protein

    See identical proteins and their annotated locations for NP_989949.1

    Status: VALIDATED

    Source sequence(s)
    AF335427, DR432119, FD587608
    UniProtKB/Swiss-Prot
    Q90Z72
    Related
    ENSGALP00000024495.2, ENSGALT00000024541.4
    Conserved Domains (2) summary
    cd14694
    Location:72131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130457
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006127.5 Reference GRCg6a Primary Assembly

    Range
    44356108..44370013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015280234.2XP_015135720.1  nuclear factor interleukin-3-regulated protein isoform X1

    UniProtKB/TrEMBL
    F1NTF2
    Conserved Domains (2) summary
    cd14694
    Location:72131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130457
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor
  2. XM_015280235.1XP_015135721.1  nuclear factor interleukin-3-regulated protein isoform X1

    UniProtKB/TrEMBL
    F1NTF2
    Conserved Domains (2) summary
    cd14694
    Location:72131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130457
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor
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