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CXCR4 C-X-C motif chemokine receptor 4 [ Gallus gallus (chicken) ]

Gene ID: 395324, updated on 5-Sep-2025
Official Symbol
CXCR4provided by CGNC
Official Full Name
C-X-C motif chemokine receptor 4provided by CGNC
Primary source
CGNC:9386
See related
Ensembl:ENSGALG00010009099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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See CXCR4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
2
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (30380917..30383608, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (30296398..30299094, complement)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112532758 Neighboring gene minichromosome maintenance complex component 6 Neighboring gene aspartyl-tRNA synthetase Neighboring gene thrombospondin type 1 domain containing 7B Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC121111338 Neighboring gene histamine N-methyltransferase-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. C-X-C chemokine receptor type 4 (CXCR4) is a key receptor for chicken primordial germ cell migration. Lee JH, et al. J Reprod Dev, 2017 Dec 15. PMID 28867677, Free PMC Article
  2. CXCR4 controls ventral migration of sympathetic precursor cells. Kasemeier-Kulesa JC, et al. J Neurosci, 2010 Sep 29. PMID 20881125, Free PMC Article
  3. Inhibitors of CXCR4 affect the migration and fate of CXCR4+ progenitors in the developing limb of chick embryos. Yusuf F, et al. Dev Dyn, 2006 Nov. PMID 16958136
  4. Expression of chemokine receptor CXCR4 during chick embryo development. Yusuf F, et al. Anat Embryol (Berl), 2005 Aug. PMID 16047188
  5. The development of thoracic and abdominal muscle depends on SDF1 and CXCR4. Yahya I, et al. Dev Biol, 2024 Feb. PMID 38070699

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The development of thoracic and abdominal muscle depends on SDF1 and CXCR4.
    Title: The development of thoracic and abdominal muscle depends on SDF1 and CXCR4.
  2. plays a critical role in the migration of primordial germ cells into the developing genital ridges.
    Title: C-X-C chemokine receptor type 4 (CXCR4) is a key receptor for chicken primordial germ cell migration.
  3. the possibility of a pivotal role for the SDF1/CXCR4 axis in DiGeorge syndrome etiology.
    Title: Disruption of CXCR4 signaling in pharyngeal neural crest cells causes DiGeorge syndrome-like malformations.
  4. demonstration of the importance of the CXCR4/SDF-1 axis for the pectoral girdle muscle formation in avians and mammals
    Title: Retrograde migration of pectoral girdle muscle precursors depends on CXCR4/SDF-1 signaling.
  5. Cxcr4 loss-of-function causes delayed migration and enhanced death of cardiac neural crest cells.
    Title: Misregulation of SDF1-CXCR4 signaling impairs early cardiac neural crest cell migration leading to conotruncal defects.
  6. Gut endoderm and angioblasts attract each other through reciprocal CXCL12 and CXCR4 signaling. This has a pivotal role in the fate establishment of the pancreatic progenitor cells.
    Title: Endoderm and mesoderm reciprocal signaling mediated by CXCL12 and CXCR4 regulates the migration of angioblasts and establishes the pancreatic fate.
  7. CXCR4-expressing subset of sympathetic ganglia (SG) cells comprises the neuronal core of the SGs, while later migrating SG-destined neural crest cells that do not express CXCR4 colonize the non-neuronal perimeter.
    Title: CXCR4 controls ventral migration of sympathetic precursor cells.
  8. Data show that in chick embryo, although CXCR4 overexpression caused a directed migration of somitic cells to the aortic region in a manner similar to Notch, no positive epistatic relationships between Notch and SDF1/CXCR4 were detected.
    Title: Notch signal is sufficient to direct an endothelial conversion from non-endothelial somitic cells conveyed to the aortic region by CXCR4.
  9. Our initial expression analysis revealed that CXCR4 is expressed by the migrating myogenic and angiogenic precursors in the developing chick limb.
    Title: Inhibitors of CXCR4 affect the migration and fate of CXCR4+ progenitors in the developing limb of chick embryos.
  10. Our descriptive data suggest a role for CXCR4 in gastrulation and other morphogenetic events connected with angiogenesis and kidney development.
    Title: Expression of chemokine receptor CXCR4 during chick embryo development.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
C-X-C chemokine receptor type 4
Names
chemokine (C-X-C motif) receptor 4
chemokine receptor CXCR4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204617.3 → NP_989948.2  C-X-C chemokine receptor type 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    A0A3S5ZPQ6, F1NAF4, Q9DGI1
    Related
    ENSGALP00010012365.1, ENSGALT00010021674.1
    Conserved Domains (2) summary
    pfam12109
    Location:16 → 48
    CXCR4_N; CXCR4 Chemokine receptor N terminal
    cd15179
    Location:49 → 323
    7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    30380917..30383608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    30296398..30299094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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