U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CXCL12 C-X-C motif chemokine ligand 12 [ Gallus gallus (chicken) ]

Gene ID: 395180, updated on 5-Sep-2025
Official Symbol
CXCL12provided by CGNC
Official Full Name
C-X-C motif chemokine ligand 12provided by CGNC
Primary source
CGNC:66195
See related
Ensembl:ENSGALG00010021867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
SDF1; SDF-1
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See CXCL12 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
5
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (19780250..19797382, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (19765436..19782453, complement)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111074 Neighboring gene uncharacterized LOC121111148 Neighboring gene uncharacterized LOC107053666 Neighboring gene transmembrane protein 72

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. SDF-1 controls the muscle and blood vessel formation of the somite. Abduelmula A, et al. Int J Dev Biol, 2016. PMID 26934287
  2. Stromal-derived factor-1 (SDF-1) expression during early chick development. Rehimi R, et al. Int J Dev Biol, 2008. PMID 18033676
  3. Cloning and characterization of chicken stromal cell derived factor-1. Read LR, et al. Dev Comp Immunol, 2005. PMID 15450754
  4. The development of thoracic and abdominal muscle depends on SDF1 and CXCR4. Yahya I, et al. Dev Biol, 2024 Feb. PMID 38070699
  5. SDF-1 chemokine signalling modulates the apoptotic responses to iron deprivation of clathrin-depleted DT40 cells. Pance A, et al. PLoS One, 2014. PMID 25162584, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The development of thoracic and abdominal muscle depends on SDF1 and CXCR4.
    Title: The development of thoracic and abdominal muscle depends on SDF1 and CXCR4.
  2. Data indicate that stromal-cell-derived factor-1 (SDF-1)controls muscle and blood vessel formation in the limb in different ways.
    Title: SDF-1 controls the muscle and blood vessel formation of the somite.
  3. SDF-1 chemokine signaling modulates the apoptotic responses to iron deprivation of clathrin-depleted Precursor B-Cells.
    Title: SDF-1 chemokine signalling modulates the apoptotic responses to iron deprivation of clathrin-depleted DT40 cells.
  4. demonstration of the importance of the CXCR4/SDF-1 axis for the pectoral girdle muscle formation in avians and mammals
    Title: Retrograde migration of pectoral girdle muscle precursors depends on CXCR4/SDF-1 signaling.
  5. The unique and non-overlapping patterns of CXCL12 and CXCL14 expression in ocular tissues suggest that these two chemokines may interact and have important functions in cell proliferation, differentiation and migration during eye development.
    Title: Expression of CXCL12 and CXCL14 during eye development in chick and mouse.
  6. Sdf1 expression is tightly coordinated with the progression of CXCR4-expressing cardiac neural crest cells & acts as a chemoattractant for them. Loss causes delayed migration & severe heart defects.
    Title: Misregulation of SDF1-CXCR4 signaling impairs early cardiac neural crest cell migration leading to conotruncal defects.
  7. Gut endoderm and angioblasts attract each other through reciprocal CXCL12 and CXCR4 signaling. This has a pivotal role in the fate establishment of the pancreatic progenitor cells.
    Title: Endoderm and mesoderm reciprocal signaling mediated by CXCL12 and CXCR4 regulates the migration of angioblasts and establishes the pancreatic fate.
  8. Comparison of CXCL14 and SDF1 reveals mostly non-overlapping or complementary expression patterns, suggesting an interactive regulation of developmental processes by these two chemokines.
    Title: Comparative expression pattern analysis of the highly conserved chemokines SDF1 and CXCL14 during amniote embryonic development.
  9. RalB was found to mediate SDF-1-induced migration
    Title: The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells.
  10. SDF-1 expression is reported during early chick development.
    Title: Stromal-derived factor-1 (SDF-1) expression during early chick development.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables CXCR chemokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chemokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in induction of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
stromal cell-derived factor 1
Names
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
chemokine ligand 12b
stromal cell derived factor 1
stromal cell-derived factor-1 beta

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389249.2 → NP_001376178.1  stromal cell-derived factor 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000231
    UniProtKB/TrEMBL
    A0A1D5PAB9, Q6T7B9
    Related
    ENSGALP00010032055.1, ENSGALT00010053197.1
    Conserved Domains (1) summary
    cd00273
    Location:27 → 88
    Chemokine_CXC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif ...

  2. NM_204510.3 → NP_989841.1  stromal cell-derived factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_989841.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000231
    UniProtKB/TrEMBL
    Q6T7C0
    Conserved Domains (1) summary
    cd00273
    Location:27 → 88
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    19780250..19797382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015288350.4 → XP_015143836.1  stromal cell-derived factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZMM6
    Related
    ENSGALP00010032059.1, ENSGALT00010053203.1
    Conserved Domains (1) summary
    cd00273
    Location:27 → 88
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    19765436..19782453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919841.1 → XP_046775797.1  stromal cell-derived factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZMM6
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials