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CG10738 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39516, updated on 14-Nov-2024

Summary

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Official Symbol
CG10738provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036368
Locus tag
Dmel_CG10738
See related
AllianceGenome:FB:FBgn0036368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10738; GYC
Summary
Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in several processes, including Golgi organization; negative regulation of cell size; and positive regulation of mitotic cell cycle. Predicted to be active in plasma membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG10738 in Genome Data Viewer
Location:
70B1-70B1; 3-40 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13450770..13465539)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13443870..13458639)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene combover Neighboring gene Jumonji domain containing 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene starvin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. Biswas KH, et al. J Mol Evol, 2009 Jun. PMID 19495554
  2. IFT88 maintains sensory function by localising signalling proteins along Drosophila cilia. Werner S, et al. Life Sci Alliance, 2024 May. PMID 38373798, Free PMC Article
  3. Classification of nonenzymatic homologues of protein kinases. Anamika K, et al. Comp Funct Genomics, 2009. PMID 19809514, Free PMC Article
  4. ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. Zacharogianni M, et al. EMBO J, 2011 Aug 16. PMID 21847093, Free PMC Article
  5. In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer. He L, et al. Elife, 2019 May 29. PMID 31140975, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables protein kinase activity IKR
Inferred from Key Residues
more info
 PubMed 
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cGMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10738-PC
CG10738-PD
CG10738-PE
CG10738-PF
NP_001246742.1
NP_001246743.1
NP_648653.2
NP_729905.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13450770..13465539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168547.2 → NP_729905.2  uncharacterized protein Dmel_CG10738, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729905.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VU79
    Conserved Domains (7) summary
    cd06370
    Location:41 → 441
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00219
    Location:597 → 847
    TyrKc; Tyrosine kinase, catalytic domain
    smart00044
    Location:886 → 1078
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:570 → 853
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:913 → 1099
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:67 → 416
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:862 → 907
    HNOBA; Heme NO binding associated

  2. NM_001259813.1 → NP_001246742.1  uncharacterized protein Dmel_CG10738, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246742.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAF5
    Conserved Domains (7) summary
    cd06370
    Location:41 → 441
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00219
    Location:584 → 834
    TyrKc; Tyrosine kinase, catalytic domain
    smart00044
    Location:873 → 1065
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:557 → 840
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:900 → 1086
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:67 → 416
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:849 → 894
    HNOBA; Heme NO binding associated

  3. NM_140396.2 → NP_648653.2  uncharacterized protein Dmel_CG10738, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648653.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQK2
    Conserved Domains (7) summary
    cd06370
    Location:41 → 441
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00219
    Location:595 → 845
    TyrKc; Tyrosine kinase, catalytic domain
    smart00044
    Location:884 → 1076
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:568 → 851
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:911 → 1097
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:67 → 416
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:860 → 905
    HNOBA; Heme NO binding associated

  4. NM_001259814.1 → NP_001246743.1  uncharacterized protein Dmel_CG10738, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246743.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFA6
    Conserved Domains (7) summary
    cd06370
    Location:41 → 441
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00219
    Location:582 → 832
    TyrKc; Tyrosine kinase, catalytic domain
    smart00044
    Location:871 → 1063
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:555 → 838
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:898 → 1084
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:67 → 416
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:847 → 892
    HNOBA; Heme NO binding associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C7LAF5 C7LAF5
M9NFA6 M9NFA6
Q8IQK2 Q8IQK2
Q9VU79 Q9VU79

Gene LinkOut

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