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SMAD3 SMAD family member 3 [ Gallus gallus (chicken) ]

Gene ID: 395132, updated on 3-Dec-2024

Summary

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Official Symbol
SMAD3provided by CGNC
Official Full Name
SMAD family member 3provided by CGNC
Primary source
CGNC:5954
See related
Ensembl:ENSGALG00010018099
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
MADH3
Orthologs
human mouse all
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Genomic context

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See SMAD3 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (18814590..18878841)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (18679407..18743653)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054215 Neighboring gene SMAD family member 6 Neighboring gene alpha- and gamma-adaptin binding protein Neighboring gene IQ motif containing H Neighboring gene chromosome 15 open reading frame 61

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell intercalation driven by SMAD3 underlies secondary neural tube formation. Gonzalez-Gobartt E, et al. Dev Cell, 2021 Apr 19. PMID 33878300
  2. Analysis of differentially expressed genes and signaling pathways related to intramuscular fat deposition in skeletal muscle of sex-linked dwarf chickens. Ye Y, et al. Biomed Res Int, 2014. PMID 24757673, Free PMC Article
  3. Knockdown of CSRP3 inhibits differentiation of chicken satellite cells by promoting TGF-β/Smad3 signaling. Han S, et al. Gene, 2019 Jul 30. PMID 30930226
  4. Decorin-induced proliferation of avian myoblasts involves the myostatin/Smad signaling pathway. Zeng QJ, et al. Poult Sci, 2014 Jan. PMID 24570433
  5. Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis. Míguez DG, et al. J Cell Sci, 2013 Dec 1. PMID 24105267

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell intercalation driven by SMAD3 underlies secondary neural tube formation.
    Title: Cell intercalation driven by SMAD3 underlies secondary neural tube formation.
  2. Results show that smad3 is phosphorylated after knocking-down CSRP3 suppressing chicken satellite cell differentiation.
    Title: Knockdown of CSRP3 inhibits differentiation of chicken satellite cells by promoting TGF-β/Smad3 signaling.
  3. IMF deposition in skeletal muscle of SLD chicken is regulated partially by pathways of adipocytokine and insulin and other downstream signaling pathways (TGF- beta /SMAD3 and Wnt/catenin- beta pathway).
    Title: Analysis of differentially expressed genes and signaling pathways related to intramuscular fat deposition in skeletal muscle of sex-linked dwarf chickens.
  4. Smad2 target proteins are activated solely by the Smad2-Smad2-Smad4 complex, whereas Smad3 targets are activated both by Smad2-Smad3-Smad4 and Smad3-Smad3-Smad4 trimers.
    Title: Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis.
  5. In conclusion, these studies suggested the decorin-mediated myostatin/Smad signaling pathway might be involved in the regulation of avian myoblast proliferation.
    Title: Decorin-induced proliferation of avian myoblasts involves the myostatin/Smad signaling pathway.
  6. In chickens with reduced muscling, satellite cells are more responsive to a Smad3-dependent TGF-beta1 signaling pathway than normal satellite cells, and a Smad3-independent pathway is also likely involved in the regulation of satellite cells.
    Title: Effect of Smad3-mediated transforming growth factor-beta1 signaling on satellite cell proliferation and differentiation in chickens.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mothers against decapentaplegic homolog 3
Names
MAD homolog 3
SMAD 3
SMAD, mothers against DPP homolog 3
TGF-beta response effector Smad3
mad3
mothers against DPP homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204475.2 → NP_989806.1  mothers against decapentaplegic homolog 3

    See identical proteins and their annotated locations for NP_989806.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000246
    UniProtKB/Swiss-Prot
    P84023
    UniProtKB/TrEMBL
    A0A8V0YYB0
    Related
    ENSGALP00010026038.1, ENSGALT00010043781.1
    Conserved Domains (2) summary
    cd10491
    Location:8 → 132
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:225 → 415
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    18814590..18878841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046898882.1 → XP_046754838.1  mothers against decapentaplegic homolog 3 isoform X1

    UniProtKB/TrEMBL
    Q9I9P1

  2. XM_015292068.4 → XP_015147554.1  mothers against decapentaplegic homolog 3 isoform X1

    UniProtKB/TrEMBL
    Q9I9P1
    Conserved Domains (2) summary
    cd10985
    Location:120 → 310
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:1 → 27
    MH1; N-terminal Mad Homology 1 (MH1) domain

  3. XM_025153794.3 → XP_025009562.1  mothers against decapentaplegic homolog 3 isoform X1

    UniProtKB/TrEMBL
    Q9I9P1
    Conserved Domains (2) summary
    cd10985
    Location:120 → 310
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:1 → 27
    MH1; N-terminal Mad Homology 1 (MH1) domain

  4. XM_046898883.1 → XP_046754839.1  mothers against decapentaplegic homolog 3 isoform X1

    UniProtKB/TrEMBL
    Q9I9P1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    18679407..18743653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046924469.1 → XP_046780425.1  mothers against decapentaplegic homolog 3 isoform X1

    UniProtKB/TrEMBL
    Q9I9P1

  2. XM_046924468.1 → XP_046780424.1  mothers against decapentaplegic homolog 3 isoform X1

    UniProtKB/TrEMBL
    Q9I9P1

  3. XM_046924467.1 → XP_046780423.1  mothers against decapentaplegic homolog 3 isoform X1

    UniProtKB/TrEMBL
    Q9I9P1

  4. XM_046924470.1 → XP_046780426.1  mothers against decapentaplegic homolog 3 isoform X1

    UniProtKB/TrEMBL
    Q9I9P1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84023.1 GenPept UniProtKB/Swiss-Prot:P84023

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.