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LDHC lactate dehydrogenase C [ Homo sapiens (human) ]

Gene ID: 3948, updated on 19-Sep-2024

Summary

Official Symbol
LDHCprovided by HGNC
Official Full Name
lactate dehydrogenase Cprovided by HGNC
Primary source
HGNC:HGNC:6544
See related
Ensembl:ENSG00000166796 MIM:150150; AllianceGenome:HGNC:6544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT32; LDH3; LDHX
Summary
Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 186.5) See more
Orthologs
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Genomic context

See LDHC in Genome Data Viewer
Location:
11p15.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18412318..18452063)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18510444..18550172)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18433865..18473610)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:18415405-18416069 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:18416070-18416735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3191 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:18417470-18417971 Neighboring gene microRNA 3159 Neighboring gene lactate dehydrogenase A Neighboring gene lactate dehydrogenase A like 6A Neighboring gene ReSE screen-validated silencer GRCh37_chr11:18507685-18507894 Neighboring gene tumor susceptibility 101 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog
Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120/41 (SFVenvBX08)-expressing microglia exhibit a 170% increase in lactate dehydrogenase (LDH) release PubMed
Envelope transmembrane glycoprotein gp41 env A lentivirus lytic peptide 1 (LLP-1) corresponding to the carboxyl terminus of HIV-1 gp41 induces a significant lactate dehydrogenase (LDH, a marker of cell death) release from human neuronal and glial cell lines PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC111073

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
involved_in lactate biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
 
involved_in lactate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lactate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in pyruvate catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pyruvate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
part_of oxidoreductase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
L-lactate dehydrogenase C chain
Names
LDH testis subunit
LDH-C
LDH-X
cancer/testis antigen 32
lactate dehydrogenase C4
testis secretory sperm-binding protein Li 234P
NP_002292.1
NP_059144.1
XP_047282890.1
XP_054224722.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011816.2 RefSeqGene

    Range
    5002..44747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002301.5NP_002292.1  L-lactate dehydrogenase C chain

    See identical proteins and their annotated locations for NP_002292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC027544, AC084117
    Consensus CDS
    CCDS7840.1
    UniProtKB/Swiss-Prot
    D3DQY4, P07864, Q6GSG8, Q7Z7J4
    UniProtKB/TrEMBL
    A0A140VKA7, D6NKH9, G9BCY7, G9BCY8
    Related
    ENSP00000280704.3, ENST00000280704.8
    Conserved Domains (1) summary
    cd05293
    Location:18329
    LDH_1; A subgroup of L-lactate dehydrogenases
  2. NM_017448.5NP_059144.1  L-lactate dehydrogenase C chain

    See identical proteins and their annotated locations for NP_059144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC027544, AC084117
    Consensus CDS
    CCDS7840.1
    UniProtKB/Swiss-Prot
    D3DQY4, P07864, Q6GSG8, Q7Z7J4
    UniProtKB/TrEMBL
    A0A140VKA7, D6NKH9, G9BCY7, G9BCY8
    Related
    ENSP00000437783.1, ENST00000541669.6
    Conserved Domains (1) summary
    cd05293
    Location:18329
    LDH_1; A subgroup of L-lactate dehydrogenases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    18412318..18452063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426934.1XP_047282890.1  L-lactate dehydrogenase C chain isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160006.1 Reference GRCh38.p14 PATCHES

    Range
    163770..166753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    18510444..18550172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368747.1XP_054224722.1  L-lactate dehydrogenase C chain isoform X1