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LDHC lactate dehydrogenase C [ Homo sapiens (human) ]

Gene ID: 3948, updated on 26-Nov-2016
Official Symbol
LDHCprovided by HGNC
Official Full Name
lactate dehydrogenase Cprovided by HGNC
Primary source
HGNC:HGNC:6544
See related
Ensembl:ENSG00000166796 HPRD:01027; MIM:150150; Vega:OTTHUMG00000167722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT32; LDH3; LDHX
Summary
Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]
Orthologs
Location:
11p15.1
Exon count:
8
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (18412298..18451246)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18433851..18472798)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microRNA 3159 Neighboring gene lactate dehydrogenase A Neighboring gene lactate dehydrogenase A like 6A Neighboring gene tumor susceptibility 101 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120/41 (SFVenvBX08)-expressing microglia exhibit a 170% increase in lactate dehydrogenase (LDH) release PubMed
Envelope transmembrane glycoprotein gp41 env A lentivirus lytic peptide 1 (LLP-1) corresponding to the carboxyl terminus of HIV-1 gp41 induces a significant lactate dehydrogenase (LDH, a marker of cell death) release from human neuronal and glial cell lines PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC111073

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-lactate dehydrogenase activity EXP
Inferred from Experiment
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
lactate biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
 
lactate oxidation IEA
Inferred from Electronic Annotation
more info
 
pyruvate metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
motile cilium IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
L-lactate dehydrogenase C chain
Names
LDH testis subunit
LDH-C
LDH-X
cancer/testis antigen 32
lactate dehydrogenase C4
lactate dehydrogenase c variant 1
lactate dehydrogenase c variant 3
lactate dehydrogenase c variant 4
lactate dehydrogenase c variant 5
testis secretory sperm-binding protein Li 234P
NP_002292.1
NP_059144.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011816.1 RefSeqGene

    Range
    5001..43941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002301.4NP_002292.1  L-lactate dehydrogenase C chain

    See identical proteins and their annotated locations for NP_002292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC084117, BC064388
    Consensus CDS
    CCDS7840.1
    UniProtKB/Swiss-Prot
    P07864
    UniProtKB/TrEMBL
    A0A140VKA7
    Related
    ENSP00000280704, OTTHUMP00000236651, ENST00000280704, OTTHUMT00000395894
    Conserved Domains (2) summary
    cd05293
    Location:18329
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25325
    L-LDH-NAD; L-lactate dehydrogenase
  2. NM_017448.3NP_059144.1  L-lactate dehydrogenase C chain

    See identical proteins and their annotated locations for NP_059144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC084117, BC090043
    Consensus CDS
    CCDS7840.1
    UniProtKB/Swiss-Prot
    P07864
    UniProtKB/TrEMBL
    A0A140VKA7
    Related
    ENSP00000437783, OTTHUMP00000236649, ENST00000541669, OTTHUMT00000395892
    Conserved Domains (2) summary
    cd05293
    Location:18329
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25325
    L-LDH-NAD; L-lactate dehydrogenase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

    Range
    18412298..18451246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017721.1XP_016873210.1  

    Conserved Domains (1) summary
    cl21454
    Location:1213
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_017017722.1XP_016873211.1  

    Conserved Domains (1) summary
    cl21454
    Location:1213
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    18433317..18472228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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