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npm1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 394478, updated on 19-Nov-2025
Official Symbol
npm1provided by Xenbase
Official Full Name
nucleophosmin (nucleolar phosphoprotein B23, numatrin)provided by Xenbase
Primary source
Xenbase:XB-GENE-1019571
See related
Ensembl:ENSXETG00000008403 AllianceGenome:Xenbase:XB-GENE-1019571
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
b23; npm; numatrin
Summary
Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of centrosome duplication; and ribosome biogenesis. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in centrosome; cytoplasm; and nuclear lumen. Is expressed in dermal system. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See npm1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (20063551..20073882)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (9664013..9674014)

Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene catenin alpha 1 Neighboring gene heat shock protein family A (Hsp70) member 9 Neighboring gene solute carrier family 23 member 1 Neighboring gene fms related tyrosine kinase 4

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC75688

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
nucleophosmin
Names
nucleophosmin 1
nucleoplasmin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203552.1 → NP_988883.1  nucleophosmin

    See identical proteins and their annotated locations for NP_988883.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059736
    UniProtKB/TrEMBL
    A0A803KIF9, F7DHY5, Q6PBF8
    Related
    ENSXETP00000018419.3, ENSXETT00000018419.4
    Conserved Domains (2) summary
    pfam03066
    Location:19 → 118
    Nucleoplasmin; Nucleoplasmin/nucleophosmin domain
    pfam16276
    Location:251 → 295
    NPM1-C; Nucleophosmin C-terminal domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    20063551..20073882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012958741.2 → XP_012814195.1  nucleophosmin isoform X1

    UniProtKB/TrEMBL
    A0A6I8QQT5, A0A803KIF9
    Related
    ENSXETP00000071986.1, ENSXETT00000079739.2
    Conserved Domains (2) summary
    pfam03066
    Location:19 → 118
    Nucleoplasmin; Nucleoplasmin/nucleophosmin domain
    pfam16276
    Location:221 → 265
    NPM1-C; Nucleophosmin C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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